MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	description	Network Comparison Type	Value Type	Filtered	Interaction Map	network_comparison	green	red

Results: HTML CSV LaTeX

Showing element 1 to 50 of 12912 in total

Network Comparison Type  : Divided
Filtered  : 1
Interaction Map  : High confidence

Rank	description	Value Type	network_comparison	green	red
1	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Ranked	2.4	24	10
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Measured	5.31521	2394.5	450.5
		Squared	28.2513	1357.07	48.0356
		Rooted	2.30547	48.9336	21.225
2	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Ranked	1.86667	28	15
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Measured	5.31521	2394.5	450.5
		Squared	28.2513	1357.07	48.0356
		Rooted	2.30547	48.9336	21.225
3	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Ranked	1.86667	28	15
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Measured	3.71868	698.5	2597.5
		Squared	13.8285	115.48	1596.92
		Rooted	1.92839	26.4292	50.9657
4	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Ranked	1.86667	28	15
	hbs1-like. [refseq;acc:nm_006620]	Measured	3.71868	698.5	2597.5
		Squared	13.8285	115.48	1596.92
		Rooted	1.92839	26.4292	50.9657
5	cytohesin 4. [swissprot;acc:q9uia0]	Ranked	1.86667	28	15
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Measured	3.39764	339.5	1153.5
		Squared	11.544	27.2805	314.926
		Rooted	1.84327	18.4255	33.9632
6	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Ranked	1.86667	28	15
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Measured	3.39764	339.5	1153.5
		Squared	11.544	27.2805	314.926
		Rooted	1.84327	18.4255	33.9632
7	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Ranked	1.49767	322	215
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	Measured	3.39764	339.5	1153.5
		Squared	11.544	27.2805	314.926
		Rooted	1.84327	18.4255	33.9632
8	db83 protein. [swissprot;acc:p57088]	Measured	3.39764	339.5	1153.5
		Squared	11.544	27.2805	314.926
		Rooted	1.84327	18.4255	33.9632
	hbs1-like. [refseq;acc:nm_006620]	Ranked	1.49767	322	215
9	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Measured	3.21581	1281.5	398.5
		Squared	10.3414	388.696	37.5863
		Rooted	1.79326	35.798	19.9625
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Ranked	1.45755	309	212
10	protein x 0004. [refseq;acc:nm_016301]
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Measured	3.21581	1281.5	398.5
		Squared	10.3414	388.696	37.5863
		Rooted	1.79326	35.798	19.9625
11	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	Measured	3.21581	1281.5	398.5
		Squared	10.3414	388.696	37.5863
		Rooted	1.79326	35.798	19.9625
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Ranked	1.45259	232	337
12	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	Measured	3.21581	1281.5	398.5
		Squared	10.3414	388.696	37.5863
		Rooted	1.79326	35.798	19.9625
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Ranked	1.45259	232	337
13	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	Measured	3.21581	1281.5	398.5
		Squared	10.3414	388.696	37.5863

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.