MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Filtered	Gene	Value Type	Rank	network_comparison	description	green	Interaction Map	Network Comparison Type	red

Results: HTML CSV LaTeX

Showing element 1 to 50 of 29840 in total

Filtered  : 0
Value Type  : Measured
Interaction Map  : High confidence

Rank	network_comparison	description	green	Network Comparison Type	red
1	6325	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	6410	Subtracted	85
	36400000	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	0.00001	Divided	364
2	6325	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	6410	Subtracted	85
	17400000	cab2. [refseq;acc:nm_033419]	174	Divided	0.00001
3	4196.8	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	19621.3	Subtracted	23818.1
	10900000	pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]	109	Divided	0.00001
4	3026	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	21730	Subtracted	18704
	8900000	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	89	Divided	0.00001
5	2673.2	histone h4. [swissprot;acc:p02304]	24446.3	Subtracted	21773.1
	8900000	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	89	Divided	0.00001
6	2430.4	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]	15605.1	Subtracted	13174.7
	8900000	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	89	Divided	0.00001
7	2430.4	zinc finger protein 277. [swissprot;acc:q9nrm2]	15605.1	Subtracted	13174.7
	4300000	sedlin. [swissprot;acc:o14582]	43	Divided	0.00001
8	2393.82	nucleoporin nup43 (p42). [swissprot;acc:q8nfh3]	7500.75	Subtracted	5106.93
	4300000	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	43	Divided	0.00001
9	75.4118	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	6410		85
	2278	ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973]	14756	Subtracted	12478
10	75.4118	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	6410	Divided	85
	1637.55	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	6193.07	Subtracted	7830.62
11	35.8425	serpin b12. [swissprot;acc:q96p63]	5.56738	Divided	199.549
	1517.74	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	7252.02	Subtracted	5734.28
12	34.8539	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	5.71669	Divided	199.249
	1469.89	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	7099.51	Subtracted	5629.62
13	29	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	47	Divided	1363
	1316			Subtracted
14	20.0687	cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946]	6.50325	Divided	130.512
	1308	apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	12125.1	Subtracted	10817.1
15	15.6	succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	156	Divided	10
	1296.57	ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]	6685.11	Subtracted	7981.68
16	15	protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]	15	Divided	1
	1279.52	nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8]	7572.88	Subtracted	8852.4
17	14.8103	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	58	Divided	859
	1250	ba271b5.1 (similar to ribosomal protein s7). [sptrembl;acc:q9h1s9]	12473	Subtracted	11223
18	11.6763	60s ribosomal protein l37a. [swissprot;acc:p12751]	26.1599	Divided	305.45
	1244.3	anaphase promoting complex subunit 11 (hepatocellular carcinoma associated ring finger protein) (hspc214). [swissprot;acc:q9nyg5]	14167	Subtracted	15411.3
19	11.6763	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	26.1599	Divided	305.45
	1211	dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]	2804	Subtracted	1593
20	1155	polyadenylate-binding protein 3 (poly(a)-binding protein 3) (pabp 3) (testis-specific poly(a)-binding protein). [swissprot;acc:q9h361]	7608		8763
	8200000	ero1-like. [refseq;acc:nm_014584]	0.00001	Divided	82
21	6.73106	syntaxin 10 (syn10). [swissprot;acc:o60499]	17.6611		118.878
	1114.25	swi/snf related, matrix associated, actin dependent regulator of chromatin subfamily d member 1 (swi/snf complex 60 kda subunit) (brg1- associated factor 60a). [swissprot;acc:q96gm5]	5690.63	Subtracted	6804.88
22	1099.6	transcription initiation factor tfiid 135 kda subunit (tafii-135) (tafii135) (tafii-130) (tafii130). [swissprot;acc:o00268]	30022.4		31122
	6000000	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	0.00001	Divided	60
23	1056.03	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]	5540.2	Subtracted	6596.23
	5900000	guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]	59	Divided	0.00001
24	5.26667	ptd016 protein. [refseq;acc:nm_016125]	158		30
	1025.76	fos-related antigen 2. [swissprot;acc:p15408]	2208.1	Subtracted	3233.86
25	5.22297	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	773	Divided	148
	917.5	adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]	1377	Subtracted	459.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.