MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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description	Rank	Gene	Value Type	Network Comparison Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 610 to 659 of 3228 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

description	Rank	green	red	network_comparison
coatomer zeta-2 subunit (zeta-2 coat protein) (zeta-2 cop). [swissprot;acc:q9p299]	1505	9377.75	10075.5	1.0744
cofilin, muscle isoform (cofilin 2). [swissprot;acc:q9y281]	1946	6608.64	6230.21	1.06074
cofilin, non-muscle isoform (18 kda phosphoprotein) (p18). [swissprot;acc:p23528]	1945
collagen alpha 3(iv) chain precursor (goodpasture antigen). [swissprot;acc:q01955]	1463	6103.92	5672.2	1.07611
collagen alpha 5(iv) chain precursor. [swissprot;acc:p29400]	1457	6103.98	5672.23	1.07612
collectin sub-family member 12 isoform i; scavenger receptor with c-type lectin; collectin placenta 1; scavenger receptor class a, member 4. [refseq;acc:nm_130386]	2881	0.00001	0.00001	1
colorectal mutant cancer protein (mcc protein). [swissprot;acc:p23508]	1810	6946.75	6520.83	1.06532
complement component 1, q subcomponent binding protein, mitochondrial precursor (glycoprotein gc1qbp) (gc1q-r protein) (hyaluronan-binding protein 1) (p32) (p33). [swissprot;acc:q07021]	2198	6657.98	6344.31	1.04944
complement component c6 precursor. [swissprot;acc:p13671]	3199	0.00001	0.00001	1
complement component c7 precursor. [swissprot;acc:p10643]	3064
complement component c8 alpha chain precursor. [swissprot;acc:p07357]	2886
complement component c8 beta chain precursor. [swissprot;acc:p07358]	3207
complement component c9 precursor. [swissprot;acc:p02748]	3057
cone-rod homeobox protein. [swissprot;acc:o43186]	2401	5916.78	5694.04	1.03912
connective tissue growth factor precursor (hypertrophic chondrocyte- specific protein 24). [swissprot;acc:p29279]	3040	0.00001	0.00001	1
connective tissue growth factor-like protein precursor (ctgf-l) (wnt1 inducible signaling pathway protein 2) (wisp-2) (connective tissue growth factor-related protein 58). [swissprot;acc:o76076]	3188
conserved oligomeric golgi complex component 1. [swissprot;acc:q8wtw3]	2836
conserved oligomeric golgi complex component 2 (low density lipoprotein receptor defect c-complementing protein). [swissprot;acc:q14746]	2216	6199.28	5910.12	1.04893
conserved oligomeric golgi complex component 3 (vesicle docking protein sec34 homolog) (p94). [swissprot;acc:q96jb2]	1779	5744.89	5386.37	1.06656
conserved oligomeric golgi complex component 6. [swissprot;acc:q9y2v7]	2453	7152.73	6931.15	1.03197
conserved oligomeric golgi complex component 7. [swissprot;acc:p83436]	1933	9701.33	10300	1.06171
conserved oligomeric golgi complex subunit 5 (13s golgi transport complex 90 kda subunit) (gtc-90) (golgi transport complex 1). [swissprot;acc:q9up83]	2682	5383.93	5358.3	1.00478
cop-coated vesicle membrane protein p24 precursor (p24a). [swissprot;acc:q15363]	3168	0.00001	0.00001	1
cop9 complex subunit 4; likely ortholog of mouse cop9 (constitutive photomorphogenic), subunit 4 (arabidopsis); cop9 (constitutive photomorphogenic, arabidopsis, homolog) subunit 4. [refseq;acc:nm_016129]	1975	7406.53	6988.29	1.05985
cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	264	4094.57	4987.58	1.2181
cop9 constitutive photomorphogenic homolog subunit 5; jun activation domain-binding protein. [refseq;acc:nm_006837]	2330	7075.51	6773.67	1.04456
cop9 signalosome complex subunit 1 (g protein pathway suppressor 1) (gps1 protein) (mfh protein). [swissprot;acc:q13098]	2827	0.00001	0.00001	1
cop9 signalosome complex subunit 2 (signalosome subunit 2) (sgn2) (thyroid receptor interacting protein 15) (trip15). [swissprot;acc:q15647]	2841
cop9 subunit 6 (mov34 homolog, 34 kd). [refseq;acc:nm_006833]	2324	7075.51	6773.67	1.04456
copper-transporting atpase 1 (ec 3.6.3.4) (copper pump 1) (menkes disease-associated protein). [swissprot;acc:q04656]	1752	6339.93	5941.29	1.0671
copper-transporting atpase 2 (ec 3.6.3.4) (copper pump 2) (wilson disease-associated protein). [swissprot;acc:p35670]	1754	6340.32	5941.83	1.06707
coproporphyrinogen iii oxidase, mitochondrial precursor (ec 1.3.3.3) (coproporphyrinogenase) (coprogen oxidase) (cox). [swissprot;acc:p36551]	2734	7939.94	7913.63	1.00332
core-binding factor, beta subunit (cbf-beta) (polyomavirus enhancer binding protein 2 beta subunit) (pebp2-beta) (pea2-beta) (sl3-3 enhancer factor 1 beta subunit) (sl3/akv core-binding factor beta subunit). [swissprot;acc:q13951]	3183	0.00001	0.00001	1
cox15 homolog isoform 2 precursor; cytochrome c oxidase subunit 15; cytochrome c oxidase assembly protein. [refseq;acc:nm_004376]	932	6194.04	5638.46	1.09853
cpg binding protein (protein containing phd finger and cxxc domain 1). [swissprot;acc:q9p0u4]	1144	6837.61	6281.21	1.08858
cpz gene product. [refseq;acc:nm_003652]	718	7364.55	6593.17	1.117
creatine kinase, b chain (ec 2.7.3.2) (b-ck). [swissprot;acc:p12277]	2735	9019.99	8991.87	1.00313
creatine kinase, m chain (ec 2.7.3.2) (m-ck). [swissprot;acc:p06732]	2704	9013.33	8980.12	1.0037
creatine kinase, sarcomeric mitochondrial precursor (ec 2.7.3.2) (s- mtck) (mib-ck) (basic-type mitochondrial creatine kinase). [swissprot;acc:p17540]	2702	9006.92	8971.66	1.00393
creatine kinase, ubiquitous mitochondrial precursor (ec 2.7.3.2) (u- mtck) (mia-ck) (acidic-type mitochondrial creatine kinase). [swissprot;acc:p12532]	2703	9007.71	8972.87	1.00388
crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945]	200	6074.21	4808.79	1.26315
crk-like protein. [swissprot;acc:p46109]	252	7859.6	6417.18	1.22477
crooked neck-like protein 1 (crooked neck homolog) (hcrn) (cgi-201) (mstp021). [swissprot;acc:q9bzj0]	366	6088.47	5189	1.17334
ctcl tumor antigen l14-2. [refseq;acc:nm_018017]	2846	0.00001	0.00001	1
ctp synthase (ec 6.3.4.2) (utp--ammonia ligase) (ctp synthetase). [swissprot;acc:p17812]	748	11212	12503.3	1.11517
cug triplet repeat rna-binding protein 1 (cug-bp1) (rna-binding protein brunol-2) (deadenylation factor cug-bp) (50 kda nuclear polyadenylated rna-binding protein) (eden-bp). [swissprot;acc:q92879]	2182	6173.41	5875.13	1.05077
cug triplet repeat, rna binding protein 2; elav-type rna-binding protein; cug triplet repeat,rna-binding protein 2; cug triplet repeat, rna-binding protein 2; neuroblastoma apoptosis-related rna-binding protein. [refseq;acc:nm_006561]	2183	6173.39	5875.11
cullin homolog 1 (cul-1). [swissprot;acc:q13616]	103	3225.65	2353.63	1.3705
cullin homolog 2 (cul-2). [swissprot;acc:q13617]	101
cyclic-amp-dependent transcription factor atf-2 (activating transcription factor 2) (camp response element binding protein cre- bp1) (hb16). [swissprot;acc:p15336]	1480	6085.22	5660.17	1.07509

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.