Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Gene Rank Value Type description Filtered green Network Comparison Type Interaction Map network_comparison red
Results: HTML CSV LaTeX Showing element 551 to 600 of 38536 in total
Network Comparison Type  : Divided
Rank
Value Type
description
Filtered
green
Interaction Map
network_comparison
red
35 Ranked protein tyrosine phosphatase type iva, member 2 isoform 1; protein tyrosine phosphatase iva2; protein tyrosine phosphatase iva; phosphatase of regenerating liver 2. [refseq;acc:nm_003479] 0 16243 Low confidence 1.37553 11808.5
tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106] 1 258.59 1.14959 297.273
Squared 28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5] 192141 High confidence 1.80879 106226
adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236] 0 647.816 12.7767 50.7031
melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361] 0.355148 Low confidence 9.62112 3.41692
necdin. [swissprot;acc:q99608] 1 61881.5 1.33073 82347.8
Rooted beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938] 0 11.7898 High confidence 2.02503 23.8747
guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148] 1 24.3679 1.65304 40.2812
melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356] 0 5.80678 Low confidence 1.69589 9.84765
regulator of g-protein signaling 12 (rgs12). [swissprot;acc:o14924] 1 63.2347 1.15329 54.8296
36 Measured guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086] 907.741 High confidence 2.02344 1836.76
heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174] 0 56 2.80357 157
melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362] 35.5 Low confidence 2.97183 105.5
proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100] 1 7593.77 1.17513 6462.09
Ranked ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511] 204.309 High confidence 1.27519 260.532
guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4] 0 14964 1.4984 22422
sam-domain protein samsn-1 (sam domain, sh3 domain and nuclear localisation signals protein 1). [swissprot;acc:q9nsi8] 9520.8 Low confidence 1.37097 13052.7
tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616] 1 258.33 1.14906 296.837
Squared cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336] 0 8.01325 High confidence 10.5625 84.64
melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732] 0.355148 Low confidence 9.62112 3.41692
melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] 1 61881.5 1.33073 82347.8
pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04] 192141 High confidence 1.80879 106226
Rooted 4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404] 0 2.18581 1.96964 4.30525
chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0] 1 64.217 Low confidence 1.15273 55.7086
guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086] 24.369 High confidence 1.65294 40.2805
hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] 0 5.80678 Low confidence 1.69589 9.84765
37 Measured 1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446] 934.348 High confidence 2.79409 334.401
guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488] 1 907.763 2.02339 1836.76
jun dimerization protein. [refseq;acc:nm_130469] 7593.77 Low confidence 1.17513 6462.09
melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361] 0 35.5 2.97183 105.5
Ranked chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0] 1 217.843 1.14874 250.244
dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0] 0 2582 High confidence 1.49458 3859
myotubularin related protein 8. [refseq;acc:nm_017677] 8993.6 Low confidence 1.36786 12302
protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256] 1 253 High confidence 1.27273 322
Squared 1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446] 0 1034.13 10.2338 101.05
melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365] 0.355148 Low confidence 9.62112 3.41692
melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] 1 61881.5 1.33073 82347.8
pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23] 192141 High confidence 1.80879 106226
Rooted guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488] 24.3691 1.65293 40.2805
melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] 0 5.80678 Low confidence 1.69589 9.84765
small nuclear ribonucleoprotein associated proteins b and b' (snrnp-b) (sm protein b/b') (sm-b/sm-b') (smb/smb'). [swissprot;acc:p14678] 9.39626 High confidence 1.94348 4.83477
testis-specific protein tex28. [swissprot;acc:o15482] 1 59.166 Low confidence 1.14428 51.7058
38 Measured guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087] 907.774 High confidence 2.02337 1836.76
melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732] 0 35.5 Low confidence 2.97183 105.5
rab11-family interacting protein 4. [refseq;acc:nm_032932] 1 8696.7 1.17403 7407.56
zinc finger protein slug (neural crest transcription factor slug) (snail homolog 2). [swissprot;acc:o43623] 0 120.429 High confidence 2.65727 320.012
Ranked cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336] 10771 1.48976 7230
glucosamine-6-phosphate isomerase. [refseq;acc:nm_138335] 1 282.937 Low confidence 1.14456 247.202
microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083] 253 High confidence 1.27273 322
williams-beuren syndrome chromosome region 14 protein (ws basic-helix- loop-helix leucine zipper protein) (ws-bhlh) (mlx interactor). [swissprot;acc:q9np71] 0 9243.55 Low confidence 1.36563 6768.72

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/