MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Gene	Rank	description	Value Type	Network Comparison Type	green	Interaction Map	Filtered	red	network_comparison

Results: HTML CSV LaTeX

Showing element 551 to 600 of 29840 in total

Interaction Map  : High confidence

Rank	description	Value Type	Network Comparison Type	green	Filtered	red	network_comparison
35	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	Measured	Subtracted	898	0	1603	705
	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	Ranked		335.359	1	267.636	67.723
	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	Measured	Divided	907.564		1836.71	2.02378
		Rooted		24.3679		40.2812	1.65304
	importin 9. [refseq;acc:nm_018085]	Ranked	Subtracted	8691.76	0	13292.2	4600.44
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Measured		18263	1	23693.7	5430.7
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Squared		192141		106226	85915
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Ranked	Divided	4871.6	0	3208.8	1.5182
	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]			204.309	1	260.532	1.27519
	serpin b12. [swissprot;acc:q96p63]	Rooted	Subtracted	1.18697	0	10.2928	9.10583
36	4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404]		Divided	2.18581		4.30525	1.96964
	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	Ranked		204.309	1	260.532	1.27519
	cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]	Squared		8.01325	0	84.64	10.5625
	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]		Subtracted	146079	1	227160	81081
	guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]	Ranked	Divided	14964	0	22422	1.4984
	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	Measured		907.741	1	1836.76	2.02344
		Rooted		24.369		40.2805	1.65294
	heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174]	Measured		56	0	157	2.80357
	huntingtin interacting protein e; huntingtin interactor protein e. [refseq;acc:nm_007076]	Squared	Subtracted	369010		363053	5957
	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	Rooted		1.2188		10.3085	9.0897
	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Measured		18263	1	23693.7	5430.7
	nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733]	Ranked		8691.76	0	13292.2	4600.44
	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	Measured		925.298		1586.07	660.772
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	Squared	Divided	192141	1	106226	1.80879
	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Ranked	Subtracted	254.434		320.927	66.493
	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	Rooted		43.1914		26.0288	17.1626
37	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Measured	Divided	934.348	0	334.401	2.79409
		Squared		1034.13		101.05	10.2338
	dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]	Ranked		2582		3859	1.49458
	dyskerin (nucleolar protein nap57) (cbf5 homolog). [swissprot;acc:o60832]	Squared	Subtracted	38271.3		32413.7	5857.6
	dystrobrevin binding protein 1; dysbindin. [refseq;acc:nm_032122]	Ranked		7533.33		12128.3	4594.97
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]			333.165	1	266.716	66.449
	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	Measured	Divided	907.763		1836.76	2.02339
		Rooted		24.3691		40.2805	1.65293
	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Measured	Subtracted	18263		23693.7	5430.7
	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	Rooted		43.1914		26.0288	17.1626
	nadh-ubiquinone oxidoreductase 13 kda-b subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-13kd-b) (ci-13kd-b) (complex i subunit b13). [swissprot;acc:q16718]			25.3969	0	16.3095	9.0874
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	Squared	Divided	192141	1	106226	1.80879
	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	Ranked		253		322	1.27273
	small nuclear ribonucleoprotein associated proteins b and b' (snrnp-b) (sm protein b/b') (sm-b/sm-b') (smb/smb'). [swissprot;acc:p14678]	Rooted		9.39626	0	4.83477	1.94348
	trs85 homolog. [swissprot;acc:q9y2l5]	Squared	Subtracted	146079	1	227160	81081
	wiskott-aldrich syndrome protein family member 3 (wasp-family protein member 3) (verprolin homology domain-containing protein 3). [swissprot;acc:q9upy6]	Measured		4550.64	0	5202.89	652.25
38	cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]	Ranked	Divided	10771		7230	1.48976
	clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]	Measured	Subtracted	6127.24		5497.01	630.23
	ero1-like. [refseq;acc:nm_014584]	Rooted		0		9.05539	9.05539
	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	Squared	Divided	0.52284		4.84	9.25713
	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	Ranked	Subtracted	333.281	1	266.933	66.348
	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	Measured	Divided	907.774		1836.76	2.02337
		Rooted		24.3692		40.2804	1.65292
	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Measured	Subtracted	18263		23693.7	5430.7

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.