MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	description	Rank	Filtered	green	Value Type	Interaction Map	Network Comparison Type	red	network_comparison

Results: HTML CSV LaTeX

Showing element 551 to 600 of 38536 in total

Network Comparison Type  : Divided

description	Rank	Filtered	green	Value Type	Interaction Map	red	network_comparison
3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]	2644	1	76.8115	Rooted	Low confidence	74.3411	1.03323
	4323		46959.8	Squared		48087	1.024
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	949		199.196	Ranked		204.147	1.02485
	971		65.1892	Rooted	High confidence	61.6649	1.05715
	1083		213.685	Ranked		220.118	1.03011
	1140		73.8482	Rooted	Low confidence	71.1233	1.03831
	1274		6371.14	Measured	High confidence	5885	1.08261
	1626		43316.1	Squared	Low confidence	45165.2	1.04269
	2082		8138.17	Measured		7887.47	1.03178
	2609		30015.7	Squared	High confidence	28935	1.03735
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	950		199.196	Ranked	Low confidence	204.147	1.02485
	972		65.1892	Rooted	High confidence	61.6649	1.05715
	1084		213.685	Ranked		220.118	1.03011
	1143		73.8482	Rooted	Low confidence	71.1233	1.03831
	1275		6371.14	Measured	High confidence	5885	1.08261
	1627		43316.1	Squared	Low confidence	45165.2	1.04269
	2090		8138.17	Measured		7887.47	1.03178
	2610		30015.7	Squared	High confidence	28935	1.03735
3-oxo-5-beta-steroid 4-dehydrogenase (ec 1.3.99.6) (delta(4)-3- ketosteroid 5-beta-reductase) (aldo-keto reductase family 1 member d1). [swissprot;acc:p51857]	1902		197.384	Ranked	Low confidence	201.286	1.01977
	2018		74.9328	Rooted		72.3967	1.03503
	2235		8361.72	Measured		8107.73	1.03133
	3174		44839.4	Squared		46389.7	1.03457
3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	897		283.472	Ranked	High confidence	272.878	1.03882
	2394		42.7253	Rooted		43.4014	1.01582
	2513		42545.5	Squared	Low confidence	44180.9	1.03844
	2547		3444.18	Measured	High confidence	3370.46	1.02187
	2650		16197	Squared		16658.1	1.02847
	3553		7932.5	Measured	Low confidence	7733.78	1.0257
	4104		71.9424	Rooted		70.109	1.02615
	4765		205.83	Ranked		206.842	1.00492
38 kda fk-506 binding protein homolog (fkbpr38) (fk506-binding protein 8). [swissprot;acc:q14318]	116		45948.1	Squared		52687.3	1.14667
	1826		69.9589	Rooted	High confidence	67.8897	1.03048
	2068		207.631	Ranked	Low confidence	203.696	1.01932
	2261		6786.23	Measured	High confidence	6486.84	1.04615
	2358		197.346	Ranked		198.181	1.00423
	2710		28336.5	Squared		27920.7	1.01489
	3779		8198.63	Measured	Low confidence	8396.92	1.02419
	4988		72.2334	Rooted		72.4649	1.0032
4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404]	36	0	2.18581		High confidence	4.30525	1.96964
	121		14.3333	Measured		19.6667	1.3721
	232		0.145878	Squared		0.108639	1.34278
	369		19704.7	Ranked		18849.7	1.04536
	481		10788.6		Low confidence	11454.3	1.0617
	680		33.079	Rooted		32.3467	1.02264
	696	1	26693.1	Squared	High confidence	22778.5	1.17186
	727		8803.2	Measured	Low confidence	8443.4	1.04261
	740	0	32991.9	Squared		33672.5	1.02063
	815		3822.12	Measured		3831.93	1.00257
	1469	1	5887.45		High confidence	5473.09	1.07571
	1579		77.0332	Rooted	Low confidence	74.3423	1.0362

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.