Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Filtered Gene Rank Value Type description green Interaction Map Network Comparison Type red network_comparison
Results: HTML CSV LaTeX Showing element 501 to 550 of 77072 in total
Filtered  : 0
Rank
Value Type
description
green
Interaction Map
Network Comparison Type
red
network_comparison
32 Ranked importin 9. [refseq;acc:nm_018085] 8691.76 High confidence Divided 13292.2 1.52929
myoglobin. [swissprot;acc:p02144] 15983.3 Low confidence 11485.4 1.39162
pnas-129. [sptrembl;acc:q9bxv8] 14842.4 Subtracted 11107.6 3734.8
syntaxin 10 (syn10). [swissprot;acc:o60499] 19014.6 High confidence 13884.4 5130.2
Squared melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] 0.355148 Low confidence Divided 3.41692 9.62112
myosin regulatory light chain 2, nonsarcomeric (myosin rlc). [swissprot;acc:p19105] 48048.2 Subtracted 54847.5 6799.3
phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086] 4.57302 High confidence Divided 76.8994 16.8159
sh3-containing grb2-like protein 1 (sh3 domain protein 2b) (extra eleven-nineteen leukemia fusion gene) (een) (een fusion partner of mll). [swissprot;acc:q99961] 27221.2 Subtracted 19892.6 7328.6
Rooted fibrillin 3. [refseq;acc:nm_032447] 47.9266 Low confidence 54.7341 6.8075
homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056] 9.43398 High confidence 0 9.43398
melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801] 5.80678 Low confidence Divided 9.84765 1.69589
ubiquitin protein ligase. [refseq;acc:nm_130466] 11.258 High confidence 24.0391 2.13529
33 Measured lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893] 39.8063 12.6208 3.15402
melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] 35.5 Low confidence 105.5 2.97183
protein cgi-147. [swissprot;acc:q9y3e5] 9192.38 High confidence Subtracted 8396.12 796.26
scribble. [refseq;acc:nm_015356] 4245.16 Low confidence 3697.8 547.36
Ranked cathepsin z precursor (ec 3.4.22.-) (cathepsin x) (cathepsin p). [swissprot;acc:q9ubr2] 7867 11515 3648
fk506-binding protein 6 (ec 5.2.1.8) (peptidyl-prolyl cis-trans isomerase) (ppiase) (rotamase) (36 kda fk506 binding protein) (fkbp- 36) (immunophilin fkbp36). [swissprot;acc:o75344] 14746.1 Divided 20324.1 1.37827
nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733] 8691.76 High confidence 13292.2 1.52929
similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517] 20387 Subtracted 15264 5123
Squared ba271b5.1 (similar to ribosomal protein s7). [sptrembl;acc:q9h1s9] 36822.7 29812 7010.7
beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938] 4.57302 Divided 76.8994 16.8159
melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358] 0.355148 Low confidence 3.41692 9.62112
microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378] 130587 Subtracted 123984 6603
Rooted fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402] 25.7294 High confidence Divided 12.3693 2.0801
melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357] 5.80678 Low confidence 9.84765 1.69589
nucleoporin nup43 (p42). [swissprot;acc:q8nfh3] 70.9983 High confidence Subtracted 61.6393 9.359
trinucleotide repeat containing 15. [refseq;acc:nm_015575] 58.122 Low confidence 64.6583 6.5363
34 Measured acrc protein; putative nuclear protein. [refseq;acc:nm_052957] 3340.03 High confidence 4131.06 791.03
glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926] 47 Divided 143 3.04255
melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] 35.5 Low confidence 105.5 2.97183
peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570] 1361.92 Subtracted 840.74 521.18
Ranked fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402] 6812 High confidence 11543 4731
fibrillin 3. [refseq;acc:nm_032447] 7506.66 Low confidence Divided 5450.5 1.37724
microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268] 17173.8 High confidence 11284 1.52196
sam-domain protein samsn-1 (sam domain, sh3 domain and nuclear localisation signals protein 1). [swissprot;acc:q9nsi8] 9520.8 Low confidence Subtracted 13052.7 3531.9
Squared coatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102). [swissprot;acc:p35606] 72701 High confidence 79383.4 6682.4
lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893] 0.697197 Divided 0.0435834 15.9968
melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362] 0.355148 Low confidence 3.41692 9.62112
th1-like; th1 drosophila homolog; th1-like (drosophila homolog); negative elongation factor proteins c and d. [refseq;acc:nm_016397] 129956 Subtracted 136552 6596
Rooted melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364] 5.80678 Divided 9.84765 1.69589
phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086] 11.7898 High confidence 23.8747 2.02503
potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] 14.4058 Low confidence Subtracted 7.90063 6.50517
succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521] 12.49 High confidence 3.16228 9.32772
35 Measured adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236] 1377 Divided 459.5 2.99674
fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402] 662 Low confidence Subtracted 153 509
filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333] 898 High confidence 1603 705
melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358] 35.5 Low confidence Divided 105.5 2.97183
Ranked bet5 homolog (multiple myeloma protein 2) (mum-2). [swissprot;acc:q9y5r8] 11141.9 Subtracted 14607.1 3465.2
importin 9. [refseq;acc:nm_018085] 8691.76 High confidence 13292.2 4600.44

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/