MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Rank	description	Value Type	Network Comparison Type	Filtered	Interaction Map	network_comparison	green	red

Results: HTML CSV LaTeX

Showing element 51 to 100 of 9634 in total

Value Type  : Measured
Network Comparison Type  : Divided

Rank	description	Filtered	Interaction Map	network_comparison	green	red
13	fk506-binding protein 6 (ec 5.2.1.8) (peptidyl-prolyl cis-trans isomerase) (ppiase) (rotamase) (36 kda fk506 binding protein) (fkbp- 36) (immunophilin fkbp36). [swissprot;acc:o75344]	0	Low confidence	14.21	115.385	8.11997
	jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]	1		1.5351	2959.19	1927.68
14	cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946]	0	High confidence	20.0687	6.50325	130.512
	guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]		Low confidence	5900000	59	0.00001
	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	1	High confidence	3.21581	1281.5	398.5
	trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]		Low confidence	1.51983	2998.1	1972.65
15	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	0		5.64642	2740.13	485.286
	succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]		High confidence	15.6	156	10
	trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]	1	Low confidence	1.51612	3007.85	1983.91
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]		High confidence	3.06659	871	2671
16	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]		Low confidence	1.34491	28492	21185
	protein kinase, lysine deficient 3. [refseq;acc:nm_020922]	0		5.636	704.5	125
	protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]		High confidence	15	15	1
	protein x 0004. [refseq;acc:nm_016301]	1		3.06659	871	2671
17	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]			2.96739	1365	460
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]		Low confidence	1.34491	28492	21185
	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	0	High confidence	14.8103	58	859
	ptd016 protein. [refseq;acc:nm_016125]		Low confidence	5.26667	158	30
18	60s ribosomal protein l37a. [swissprot;acc:p12751]		High confidence	11.6763	26.1599	305.45
	camp-regulated phosphoprotein 19 (arpp-19) [contains: camp-regulated phosphoprotein 16 (arpp-16)]. [swissprot;acc:p56211]		Low confidence	5.21053	19	99
	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	1		1.32027	7251	5492.04
	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]		High confidence	2.75351	1865.5	677.5
19	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	0		11.6763	26.1599	305.45
		1	Low confidence	1.29112	3915.4	3032.56
	fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	0		4.3268	662	153
	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	1	High confidence	2.75351	1865.5	677.5
20	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	0	Low confidence	4.10072	139	570
	ero1-like. [refseq;acc:nm_014584]		High confidence	8200000	0.00001	82
	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	1		2.75351	1865.5	677.5
	retinoblastoma-associated factor 600. [refseq;acc:nm_020765]		Low confidence	1.29106	9368.87	7256.71
21	cytochrome p450 27, mitochondrial precursor (ec 1.14.-.-) (cytochrome p-450c27/25) (sterol 26-hydroxylase) (sterol 27-hydroxylase) (vitamin d(3) 25-hydroxylase) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase). [swissprot;acc:q02318]			1.29072	3917.88	3035.43
	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]		High confidence	2.75351	1865.5	677.5
	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	0	Low confidence	3.90833	434.911	111.278
	syntaxin 10 (syn10). [swissprot;acc:o60499]		High confidence	6.73106	17.6611	118.878
22	carbohydrate (n-acetylglucosamine 6-o) sulfotransferase 6; macular dystrophy, corneal, 1; carbohydate sulfotransferase 6; corneal n-acetylglucosamine 6-sulfotransferase. [refseq;acc:nm_021615]		Low confidence	3700000	0.00001	37
	cytochrome p450 24a1, mitochondrial precursor (ec 1.14.-.-) (p450- cc24) (vitamin d(3) 24-hydroxylase) (1,25-dihydroxyvitamin d(3) 24- hydroxylase) (24-ohase). [swissprot;acc:q07973]	1		1.27828	3997.02	3126.88
	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]		High confidence	2.75351	1865.5	677.5
	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	0		6000000	0.00001	60
23	carbohydrate (n-acetylglucosamine-6-o) sulfotransferase 2; carbohydrate (chondroitin 6/keratan) sulfotransferase 2. [refseq;acc:nm_004267]		Low confidence	3700000		37
	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	1		1.27696	32028.5	40899
	gbp protein isoform a. [refseq;acc:nm_017870]		High confidence	2.7072	1894.39	699.76
	guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]	0		5900000	59	0.00001
24	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	1	Low confidence	1.24965	4577.5	5720.25
	cathepsin z precursor (ec 3.4.22.-) (cathepsin x) (cathepsin p). [swissprot;acc:q9ubr2]	0		3.2013	493	154
	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	1	High confidence	2.21818	2108.52	950.561
	ptd016 protein. [refseq;acc:nm_016125]	0		5.26667	158	30
25	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	1		2.0534	892.67	1833.01
	histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]		Low confidence	1.24627	4691.96	5847.46
	lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893]	0		3.15402	39.8063	12.6208
	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]		High confidence	5.22297	773	148

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.