MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Value Type	description	green	Interaction Map	Filtered	red	network_comparison	Gene	Rank	Network Comparison Type

Results: HTML CSV LaTeX

Showing element 51 to 100 of 77072 in total

Value Type  : Measured

description	green	Interaction Map	Filtered	red	network_comparison	Rank	Network Comparison Type
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312]	8956.98	Low confidence	1	8566.17	1.04562	591	Divided
					390.81	498	Subtracted
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758]	6788.96	High confidence		6336.22	1.07145	1600	Divided
					452.74	1404	Subtracted
	8288.57	Low confidence		7982.87	1.03829	993	Divided
					305.7	997	Subtracted
15 kda selenoprotein precursor. [swissprot;acc:o60613]	6933.36	High confidence		6344.41	1.09283	1043	Divided
					588.95	865	Subtracted
	8083.96	Low confidence		7881.96	1.02563	3577	Divided
					202	3582	Subtracted
15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [swissprot;acc:p15428]	0	High confidence		0	0	2855
	0.00001			0.00001	1		Divided
	8425.81	Low confidence		8165.8	1.03184	2067
					260.01	1863	Subtracted
16.7kd protein. [refseq;acc:nm_016139]	8483.17			8297.71	1.02235	4005	Divided
					185.46	3907	Subtracted
17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]	6113.96	High confidence		5964.17	1.02511	2521	Divided
					149.79	2496	Subtracted
	8498.04	Low confidence		8189.31	1.0377	1051	Divided
					308.73	975	Subtracted
17-beta-hydroxysteroid dehydrogenase type vii-like. [refseq;acc:nm_182829]	4869.42		0	4825.89	1.00902	778	Divided
					43.53	627	Subtracted
	8689.28		1	8316.12	1.04487	631	Divided
					373.16	562	Subtracted
2,4-dienoyl coa reductase 2, peroxisomal; peroxisomal 2,4-dienoyl-coa reductase. [refseq;acc:nm_020664]	8354			8218.07	1.01654	4609	Divided
					135.93	4587	Subtracted
2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor (ec 2.4.1.45) (udp-galactose-ceramide galactosyltransferase) (ceramide udp-galactosyltransferase) (cerebroside synthase). [swissprot;acc:q16880]	7708.55			7480.51	1.03048	2443	Divided
					228.04	2870	Subtracted
2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83]	6192.72	High confidence		5743.36	1.07824	1393	Divided
					449.36	1426	Subtracted
	7938.52	Low confidence		7690.22	1.03229	1973	Divided
					248.3	2251	Subtracted
2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	6362.25	High confidence		6200.39	1.0261	2506	Divided
					161.86	2455	Subtracted
	8332.97	Low confidence		8029.13	1.03784	1032	Divided
					303.84	1019	Subtracted
2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [swissprot;acc:p12694]	6957.34	High confidence		6737.15	1.03268	2451	Divided
					220.19	2344	Subtracted
	8054.46	Low confidence		7848.62	1.02623	3458	Divided
					205.84	3506	Subtracted
2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [swissprot;acc:p21953]	6048.94	High confidence		5783.76	1.04585	2288	Divided
					265.18	2239	Subtracted
	8033.99	Low confidence		7871.26	1.02067	4165	Divided
					162.73	4352	Subtracted
20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	5843.51	High confidence		4266.04	1.36977	107	Divided
					1577.47	179	Subtracted
	8143.47	Low confidence		7647.22	1.06489	234	Divided
					496.25	269	Subtracted
25 kda brain-specific protein (p25-alpha). [swissprot;acc:o94811]	8007.43			7697.01	1.04033	863	Divided
					310.42	951	Subtracted

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.