MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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description	Rank	Gene	Value Type	Filtered	Interaction Map	green	red	Network Comparison Type	network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 16578 in total

Value Type  : Ranked
Filtered  : 1

description	Rank	Interaction Map	green	red	Network Comparison Type	network_comparison
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758]	2366	High confidence	202.529	203.353	Divided	1.00407
	2393				Subtracted	0.824
15 kda selenoprotein precursor. [swissprot;acc:o60613]	1920		212.432	214.522		2.09
	1948				Divided	1.00984
	4465	Low confidence	201.104	202.928		1.00907
	4468				Subtracted	1.824
15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [swissprot;acc:p15428]	2855	High confidence	0	0		0
			0.00001	0.00001	Divided	1
	4126	Low confidence	195.778	197.858		1.01062
	4182				Subtracted	2.08
16.7kd protein. [refseq;acc:nm_016139]	3267		195.864	198.949	Divided	1.01575
	3341				Subtracted	3.085
17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]	1029	High confidence	217.998	211.449		6.549
	1051				Divided	1.03097
	1803	Low confidence	195.655	199.592		1.02012
	1836				Subtracted	3.937
17-beta-hydroxysteroid dehydrogenase type vii-like. [refseq;acc:nm_182829]	2142		192.884	196.577	Divided	1.01915
	2279				Subtracted	3.693
2,4-dienoyl coa reductase 2, peroxisomal; peroxisomal 2,4-dienoyl-coa reductase. [refseq;acc:nm_020664]	3842		198.422	201.014		2.592
	3846				Divided	1.01306
2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor (ec 2.4.1.45) (udp-galactose-ceramide galactosyltransferase) (ceramide udp-galactosyltransferase) (cerebroside synthase). [swissprot;acc:q16880]	4270		205.097	207	Subtracted	1.903
	4455				Divided	1.00928
2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83]	870		201.99	207.026	Subtracted	5.036
	941				Divided	1.02493
	1954	High confidence	222.969	225.019	Subtracted	2.05
	2007				Divided	1.00919
2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	992	Low confidence	196.729	201.562	Subtracted	4.833
	994				Divided	1.02457
	1160	High confidence	214.041	208.55		1.02633
	1164				Subtracted	5.491
2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [swissprot;acc:p12694]	1484		202.726	198.927	Divided	1.0191
	1515				Subtracted	3.799
	4538	Low confidence	201.202	202.824		1.622
	4541				Divided	1.00806
2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [swissprot;acc:p21953]	1336	High confidence	213.875	218.47	Subtracted	4.595
	1389				Divided	1.02148
	1394	Low confidence	198.891	203.206	Subtracted	4.315
	1439				Divided	1.0217
20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	140	High confidence	198.011	228.306	Subtracted	30.295
	183				Divided	1.153
	276	Low confidence	191.474	199.939		1.04421
	295				Subtracted	8.465
25 kda brain-specific protein (p25-alpha). [swissprot;acc:o94811]	1046		199.188	203.933		4.745
	1085				Divided	1.02382
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	14		238.476	286.396	Subtracted	47.92
	25				Divided	1.20094
	3079	High confidence	0	0	Subtracted	0
			0.00001	0.00001	Divided	1
26s protease regulatory subunit 4 (p26s4). [swissprot;acc:q03527]	2497		216.137	215.581	Subtracted	0.556
	2503				Divided	1.00258

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.