Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 951 to 1000 of 7460 in total
Value Type  : Measured
Interaction Map  : High confidence
Rank
description
Network Comparison Type
Filtered
red
green
network_comparison
238 signal-induced proliferation-associated 1-like 1. [refseq;acc:nm_015556] Subtracted 0 494.417 359.631 134.786
star-related lipid transfer protein 8 (stard8) (start domain- containing protein 8). [swissprot;acc:q92502] 1 9649.61 11053.5 1403.89
239 carboxypeptidase b precursor. [refseq;acc:nm_020361] Divided 7711.38 6265.8 1.23071
guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148] 0 382.142 434.366 1.13666
leucine rich repeat (in flii) interacting protein 1. [refseq;acc:nm_004735] Subtracted 11170.7 11305 134.3
neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822] 1 9649.61 11053.5 1403.89
240 mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088] Divided 7711.36 6265.79 1.23071
mitogen-activated protein kinase-activated protein kinase 3; mapkap kinase 3. [refseq;acc:nm_004635] Subtracted 9649.61 11053.5 1403.89
putative eukaryotic translation initiation factor 1a (eif-1a) (eif- 4c). [swissprot;acc:o75642] Divided 0 1475.83 1676.18 1.13575
signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458] Subtracted 903.967 771.309 132.658
241 hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712] 3614.24 3481.87 132.37
keratin associated protein 9.2. [refseq;acc:nm_031961] Divided 1225.47 1079.01 1.13574
mitogen-activated protein kinase 14 (ec 2.7.1.37) (mitogen-activated protein kinase p38alpha) (map kinase p38alpha) (cytokine suppressive anti-inflammatory drug binding protein) (csaid binding protein) (csbp) (max-interacting protein 2) (map kinase mxi2) (sapk2a). [swissprot;acc:q16539] Subtracted 1 9649.61 11053.5 1403.89
plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872] Divided 7711.31 6265.76 1.23071
242 likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745] Subtracted 0 1293.73 1161.64 132.09
max protein. [swissprot;acc:p25912] Divided 1 4640.26 5704.87 1.22943
neuronal acetylcholine receptor protein, alpha-4 chain precursor. [swissprot;acc:p43681] Subtracted 9649.61 11053.5 1403.89
splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393] Divided 0 729.216 642.343 1.13524
243 dead-box protein. [refseq;acc:nm_018665] Subtracted 313.667 183 130.667
homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839] Divided 1 4246.95 5208.98 1.22652
keratin associated protein 4.3 (fragment). [sptrembl;acc:q9byr4] 0 1225.09 1079.36 1.13502
neuronal acetylcholine receptor protein, alpha-3 chain precursor. [swissprot;acc:p32297] Subtracted 1 9649.61 11053.5 1403.89
244 keratin associated protein 2-4; keratin associated protein 2.4. [refseq;acc:nm_033184] Divided 0 1225.09 1079.36 1.13502
sphingosine kinase 2 (ec 2.7.1.-) (sk 2) (spk 2). [swissprot;acc:q9nra0] Subtracted 1 9649.61 11053.5 1403.89
sterol regulatory element binding protein-2 (srebp-2) (sterol regulatory element-binding transcription factor 2). [swissprot;acc:q12772] 0 1334.19 1205.1 129.09
ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807] Divided 1 4250.14 5211.25 1.22614
245 basic proline-rich peptide p-e (ib-9). [swissprot;acc:p02811] Subtracted 0 292 421 129
homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272] Divided 1 4251.65 5212.33 1.22595
keratin associated protein 1.5. [refseq;acc:nm_031957] 0 1225.09 1079.36 1.13502
methyltransferase like 2. [refseq;acc:nm_018396] Subtracted 1 13241.4 11864 1377.4
246 cytoplasmic dynein light chain (t-complex testis-specific protein 1 homolog) (protein cw-1). [swissprot;acc:q15763]
f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755] 0 150.673 279.24 128.567
homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838] Divided 1 4252.66 5213.05 1.22583
keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371] 0 1225.09 1079.36 1.13502
247 fzr1 protein; fizzy-related protein; cdc20-like 1b. [refseq;acc:nm_016263] Subtracted 1 13241.4 11864 1377.4
keratin associated protein 1-3; keratin associated protein 1.3. [refseq;acc:nm_030966] Divided 0 1225.09 1079.36 1.13502
tyrosinase-related gene segment, exon 5 (fragment). [sptrembl;acc:q15677] Subtracted 271.484 142.981 128.503
wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768] Divided 1 6416.68 7865.15 1.22574
248 adenine phosphoribosyltransferase (ec 2.4.2.7) (aprt). [swissprot;acc:p07741] Subtracted 0 2323.8 2452.23 128.43
keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060] Divided 1225.09 1079.37 1.135
proprotein convertase subtilisin/kexin type 5 precursor (ec 3.4.21.-) (proprotein convertase pc5) (subtilisin/kexin-like protease pc5) (convertase pc5) (pc6) (hpc6). [swissprot;acc:q92824] Subtracted 1 13241.4 11864 1377.4
proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108] Divided 6417.18 7859.6 1.22477
249 estradiol 17 beta-dehydrogenase 1 (ec 1.1.1.62) (17-beta-hsd 1) (placental 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-hsd) (e2dh). [swissprot;acc:p14061] Subtracted 0 2323.8 2452.23 128.43
keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059] Divided 1225.08 1079.37 1.135
small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330] Subtracted 1 4405.4 5782.08 1376.68
tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684] Divided 6417.18 7859.59 1.22477
250 keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8] 0 1225.08 1079.37 1.135
proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931] 1 6417.18 7859.6 1.22477
ptd016 protein. [refseq;acc:nm_016125] Subtracted 0 30 158 128
sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489] 1 4578.09 5939.91 1361.82

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/