Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Filtered Rank Value Type green Gene description Network Comparison Type Interaction Map network_comparison red

Results: HTML CSV LaTeX

Showing element 451 to 500 of 77072 in total

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Rank	Value Type	green	description	Network Comparison Type	Interaction Map	network_comparison	red
29	Measured	2399.76	regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754]	Subtracted	High confidence	849.19	3248.95
	Measured	21088.5	cytochrome c oxidase polypeptide viic, mitochondrial precursor (ec 1.9.3.1). [swissprot;acc:p15954]		Low confidence	582.8	20505.7
	Ranked	8257	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]		High confidence	5473.5	13730.5
		8687.07	solute carrier family 12 (potassium/chloride transporters), member 9; cation-chloride cotransporter-interacting protein. [refseq;acc:nm_020246]	Divided	Low confidence	1.39628	12129.6
		11625	phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086]	Divided	High confidence	1.57201	7395
		15924	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	Subtracted	Low confidence	4163	11761
	Squared	0.355148	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Divided	Low confidence	9.62112	3.41692
		141.427	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	Divided	High confidence	27.2794	5.18438
		15317.3	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	Subtracted	Low confidence	7115.03	8202.27
		64272.5	galectin-4 (lactose-binding lectin 4) (l-36 lactose binding protein) (l36lbp) (antigen ny-co-27). [swissprot;acc:p56470]		High confidence	7856.1	72128.6
	Rooted	1.80368	cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946]		High confidence	9.57372	11.3774
		6.85565	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	Divided	Low confidence	1.7443	11.9583
		7.34614	microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268]	Divided	High confidence	2.42243	17.7955
		9.246	pnas-129. [sptrembl;acc:q9bxv8]	Subtracted	Low confidence	7.1816	16.4276
30	Measured	35.5	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Divided	Low confidence	2.97183	105.5
		111.739	dystrophin. [swissprot;acc:p11532]	Divided	High confidence	3.82335	427.217
		704.5	protein kinase, lysine deficient 3. [refseq;acc:nm_020922]	Subtracted	Low confidence	579.5	125
		4102.97	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]		High confidence	837.72	3265.25
	Ranked	8257	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]			5473.5	13730.5
		11625	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	Divided		1.57201	7395
		13210.4	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	Subtracted	Low confidence	4151.3	17361.7
		15987.1	alpha 2 globin. [refseq;acc:nm_000517]	Divided		1.39185	11486.2
	Squared	0.355148	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]			9.62112	3.41692
		141.944	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]		High confidence	22.6931	6.25494
		7964.87	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	Subtracted	Low confidence	6882.39	1082.48
		31089.6	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	Subtracted	High confidence	7779.1	23310.5
	Rooted	7.5	protein tyrosine phosphatase type iva, member 2 isoform 1; protein tyrosine phosphatase iva2; protein tyrosine phosphatase iva; phosphatase of regenerating liver 2. [refseq;acc:nm_003479]	Divided	Low confidence	1.74163	13.0622
		9.43398	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	Subtracted	High confidence	9.43398	0
		12.5698	ptd016 protein. [refseq;acc:nm_016125]	Divided	High confidence	2.29492	5.47723
		12.5698	ptd016 protein. [refseq;acc:nm_016125]	Subtracted	Low confidence	7.09257	5.47723
31	Measured	0.00001	dok-like protein. [refseq;acc:nm_024872]	Divided	High confidence	3500000	35
		35.5	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Divided	Low confidence	2.97183	105.5
		2637	spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [swissprot;acc:q13813]	Subtracted	High confidence	804	1833
		3114.19	adenomatous polyposis coli like. [refseq;acc:nm_005883]	Subtracted	Low confidence	570	2544.19
	Ranked	5266.67	leucine rich repeat (in flii) interacting protein 1. [refseq;acc:nm_004735]	Divided	High confidence	1.53462	8082.33
		6248	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	Subtracted	High confidence	5379	11627
		9583.37	trinucleotide repeat containing 15. [refseq;acc:nm_015575]	Subtracted	Low confidence	4007.66	5575.71
		15984.3	hemoglobin gamma-a and gamma-g chains. [swissprot;acc:p02096]	Divided		1.39168	11485.6
	Squared	0.355148	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]			9.62112	3.41692
		103.726	fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]		High confidence	18.7211	5.54059
		26377.5	scribble. [refseq;acc:nm_015356]	Subtracted	Low confidence	6838.2	19539.3
		27772	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]		High confidence	7674.2	35446.2
	Rooted	9.43398	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]		High confidence	9.43398	0
		12.7411	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	Divided	Low confidence	1.73139	7.3589
		27.8029	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	Divided	High confidence	2.28539	12.1655
		51.8401	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	Subtracted	Low confidence	6.8546	58.6947
32	Measured	35.5	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Divided	Low confidence	2.97183	105.5
		58	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	Subtracted	High confidence	801	859
		184	cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]	Divided	High confidence	3.25	598
		3026.64	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]	Subtracted	Low confidence	550.54	2476.1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/