MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	Value Type	description	Filtered	Network Comparison Type	Interaction Map	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 401 to 450 of 3730 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	description	Filtered	red	network_comparison	green
201	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]	0	16853	1.1144	15123
	splicing factor 4 isoform b; rna-binding protein. [refseq;acc:nm_021164]	1	240.133	1.13601	211.382
202	serpin b11. [swissprot;acc:q96p15]	0	16853	1.1144	15123
	short transient receptor potential channel 4 (trpc4) (trp-related protein 4) (htrp-4) (htrp4). [swissprot;acc:q9ubn4]	1	201.478	1.13553	228.784
203	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]	0	16853	1.1144	15123
	ebp50-pdz interactor of 64 kda (epi64 protein). [swissprot;acc:q9bxi6]	1	201.515	1.13516	228.752
204	dipeptidyl peptidase 8 isoform 2; dipeptidyl peptidase 8. [refseq;acc:nm_017743]	0	15081.8	1.11406	16802.1
	short transient receptor potential channel 5 (trpc5) (htrp-5) (htrp5). [swissprot;acc:q9ul62]	1	201.515	1.13516	228.752
205	60s ribosomal protein l23a. [swissprot;acc:p29316]	0	11844.9	1.11363	10636.3
	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	1	228.1	1.13501	200.968
206	hepatitis c virus core-binding protein 6; cervical cancer oncogene 3. [refseq;acc:nm_023934]	0	7479	1.11361	6716
	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	1	228.085	1.13472	201.006
207	dc11 protein. [refseq;acc:nm_020186]	0	7479	1.11361	6716
	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	1	285.684	1.13261	252.234
208	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	0	11846.3	1.11354	10638.4
	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	1	285.684	1.13261	252.234
209	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]
	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	0	775	1.11351	696
210	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	1	285.684	1.13261	252.234
	mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362]	0	17144.8	1.11289	15405.6
211	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	1	285.684	1.13261	252.234
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	0	10367	1.11231	9320.25
212	cullin homolog 1 (cul-1). [swissprot;acc:q13616]	1	285.684	1.13261	252.234
	metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832]	0	18241.7	1.11196	16405
213	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]	1	210.693	1.127	186.95
	protein disulfide isomerase precursor (pdi) (ec 5.3.4.1) (prolyl 4- hydroxylase beta subunit) (cellular thyroid hormone binding protein) (p55). [swissprot;acc:p07237]	0	9379.47	1.11179	8436.39
214	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	1	191.644	1.12605	170.192
	probable glutamyl-trna(gln) amidotransferase subunit b, mitochondrial precursor (ec 6.3.5.-) (glu-adt subunit b) (cytochrome oxidase assembly factor pet112 homolog). [swissprot;acc:o75879]	0	7621.99	1.11176	8473.85
215	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	1	112	1.125	126
	myosin vi. [swissprot;acc:q9um54]	0	10121.5	1.11154	11250.5
216	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]		10559.7	1.11102	11732
	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	1	112	1.125	126
217	baculoviral iap repeat-containing protein 5 (apoptosis inhibitor survivin) (apoptosis inhibitor 4). [swissprot;acc:o15392]	0	7101.79	1.10858	6406.18
	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	1	112	1.125	126
218	lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893]	0	19355	1.10795	17469.2
	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	1	112	1.125	126
219	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]
	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040]	0	12196.2	1.10777	11009.7
220	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	1	112	1.125	126
	neurocalcin delta. [swissprot;acc:p29554]	0	13973.6	1.10734	15473.5
221	estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454]		12190.3	1.10721	13497.2
	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	1	112	1.125	126
222	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	0	12183	1.10622	11013.2
	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	1	112	1.125	126
223	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]
	pnas-18. [sptrembl;acc:q9bzu3]	0	12602.7	1.10608	13939.6
224	atp-dependent clp protease atp-binding subunit clpx-like, mitochondrial precursor. [swissprot;acc:o76031]		9815.6	1.10413	8889.93
	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	1	185.969	1.12285	165.623
225	40s ribosomal protein s29. [swissprot;acc:p30054]	0	11035.3	1.10378	9997.71
	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	1	226.471	1.12243	201.769

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.