Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Value Type Interaction Map Network Comparison Type description green Gene network_comparison red Rank Filtered
Results: HTML CSV LaTeX Showing element 401 to 450 of 38536 in total
Value Type  : Measured
Interaction Map  : High confidence
Network Comparison Type  : Divided
description
green
network_comparison
red
Rank
Filtered
atp synthase alpha chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p25705] 6218.77 1.10592 5623.18 834 1
atp synthase b chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p24539] 4126.96 1.05994 4374.32 1970
atp synthase beta chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p06576] 6173.23 1.10322 5595.65 869
atp synthase coupling factor 6, mitochondrial precursor (ec 3.6.3.14) (f6). [swissprot;acc:p18859] 0.00001 1 0.00001 2893
atp synthase coupling factor b, mitochondrial precursor. [swissprot;acc:q99766] 6610.46 1.07439 6152.78 1507
atp synthase delta chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p30049] 6655.11 1.10917 6000.07 811
atp synthase f chain, mitochondrial (ec 3.6.3.14). [swissprot;acc:p56134] 7315.59 1.05706 6920.71 2036
atp synthase g chain, mitochondrial (ec 3.6.3.14) (atpase subunit g). [swissprot;acc:o75964] 0.00001 1 0.00001 2834
atp synthase gamma chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p36542] 6263.02 1.10702 5657.53 824
atp synthase mitochondrial f1 complex assembly factor 2. [refseq;acc:nm_145691] 5131.89 1.06953 5488.7 1657
atp synthase oligomycin sensitivity conferral protein, mitochondrial precursor (ec 3.6.3.14) (oscp). [swissprot;acc:p48047] 6263.02 1.10702 5657.53 825
atp-binding cassette, sub-family c, member 10; multidrug resistance-associated protein 7. [refseq;acc:nm_033450] 7741.14 1.00515 7780.98 2676
atp-binding cassette, sub-family d, member 3 (70 kda peroxisomal membrane protein) (pmp70). [swissprot;acc:p28288] 6555.41 1.07829 6079.46 1380
atp-citrate synthase (ec 2.3.3.8) (atp-citrate (pro-s-)-lyase) (citrate cleavage enzyme). [swissprot;acc:p53396] 6421.65 1.05882 6064.92 2005
atp-dependent clp protease atp-binding subunit clpx-like, mitochondrial precursor. [swissprot;acc:o76031] 931.405 1.05332 884.254 377 0
5472.96 1.07184 5106.13 1574 1
atp-dependent dna helicase ii, 70 kda subunit (lupus ku autoantigen protein p70) (ku70) (70 kda subunit of ku antigen) (thyroid-lupus autoantigen) (tlaa) (ctc box binding factor 75 kda subunit) (ctcbf) (ctc75). [swissprot;acc:p12956] 402 1.47761 594 100 0
6108.72 1.06433 5739.49 1838 1
atp-dependent dna helicase ii, 80 kda subunit (lupus ku autoantigen protein p86) (ku86) (ku80) (86 kda subunit of ku antigen) (thyroid- lupus autoantigen) (tlaa) (ctc box binding factor 85 kda subunit) (ctcbf) (ctc85) (nuclear factor iv) (dna-repair protein xrcc5). [swissprot;acc:p13010] 1839
atp-dependent dna helicase q5 (recq protein-like 5) (recq5). [swissprot;acc:o94762] 6464.16 1.07274 6025.86 1552
atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1] 4264.46 1.1463 3720.18 463
atp-dependent rna helicase ddx24 (dead-box protein 24). [swissprot;acc:q9gzr7] 4081.21 1.18883 3432.96 326
atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072] 4236.95 1.16339 3641.89 392
atp-dependent rna helicase rok1; atp-dependent rna helicase. [refseq;acc:nm_007010] 4477.43 1.10581 4049 836
atpase inhibitor, mitochondrial precursor. [swissprot;acc:q9uii2] 5414.23 1.12542 4810.85 642
atpase, h+ transporting, lysosomal 38kda, v0 subunit d isoform 2. [refseq;acc:nm_152565] 6533.39 1.11298 5870.2 760
atpase, h+ transporting, lysosomal v0 subunit a isoform 4; vacuolar proton pump 116 kda accessory subunit; vacuolar proton pump, subunit 2; h(+)-transporting two-sector atpase, noncatalytic accessory protein 1b; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1b; renal tubular acidosis; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kd). [refseq;acc:nm_020632] 6547.99 1.1116 5890.59 789
atrophin-1 (dentatorubral-pallidoluysian atrophy protein). [swissprot;acc:p54259] 6048.88 1.04585 5783.7 2283
atrophin-1 interacting protein 1; activin receptor interacting protein 1; likely ortholog of mouse activin receptor interacting protein 1; atrophin-1 interacting protein a; membrane associated guanylate kinase 2; activin receptor interacting p. [refseq;acc:nm_012301] 5492.58 1.0437 5262.6 2355
au rna-binding protein/enoyl-coenzyme a hydratase precursor; au rna-binding protein/enoyl-coenzyme a hydratase; 3-methylglutaconyl-coa hydratase; mga type i. [refseq;acc:nm_001698] 0.00001 1 0.00001 2913
autoantigen ngp-1. [swissprot;acc:q13823] 4274.79 1.13506 3766.14 566
autophagy protein 12-like (apg12-like). [swissprot;acc:o94817] 9352.11 1.25723 11757.8 203
autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0] 5815.13 1.15974 6744.05 414
axonemal dynein light intermediate polypeptide 1 (inner dynein arm light chain, axonemal) (hp28). [swissprot;acc:o14645] 7526.2 1.11125 6772.75 792
b-cell cll/lymphoma 6, member b (zinc finger protein); zinc finger protein 62. [refseq;acc:nm_181844] 9251.2 1.07011 9899.79 1633
b-cell lymphoma 3-encoded protein (bcl-3 protein). [swissprot;acc:p20749] 8211.05 1.00824 8278.73 2658
b-cell lymphoma 6 protein (bcl-6) (zinc finger protein 51) (laz-3 protein) (bcl-5). [swissprot;acc:p41182] 9251.16 1.07011 9899.73 1635
b-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (p94) (v-raf murine sarcoma viral oncogene homolog b1). [swissprot;acc:p15056] 13977.7 1.26708 17710.9 198
b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681] 3438.82 1.13022 3886.62 609
ba127l20.1 (novel glutathione-s-transferase). [sptrembl;acc:q9h4y5] 4126.96 1.05994 4374.32 1973
ba138e2.1.2 (formin-binding protein 17 (fbp17), isoform 2). [sptrembl;acc:q96lh6] 5127.66 1.06782 5475.44 1728
ba203i16.1 (hypothetical protein kiaa0970). [sptrembl;acc:q9h1w1] 0.00001 1 0.00001 3117
ba207c16.2 (fragment). [sptrembl;acc:q9nql7] 7108.89 1.01298 7017.82 2636
ba271b5.1 (similar to ribosomal protein s7). [sptrembl;acc:q9h1s9] 6186.39 1.06977 5782.92 1641
12473 1.11138 11223 292 0
ba304i5.1 (novel lipase) (fragment). [sptrembl;acc:q96lg2] 6220.45 1.095 5680.76 1000 1
ba305p22.3 (breast carcinoma amplified sequence 4). [sptrembl;acc:q8ndy6] 10773.5 1.10019 11852.9 907
ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36] 904.149 1.21678 743.066 191 0
5907.12 1.20203 4914.27 299 1
ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5] 5616.59 1.05402 5328.73 2130

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/