MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Rank	description	Value Type	Interaction Map	Network Comparison Type	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 401 to 450 of 3730 in total

Value Type  : Ranked
Interaction Map  : High confidence
Network Comparison Type  : Divided

Rank	description	Filtered	green	red	network_comparison
201	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]	0	15123	16853	1.1144
	splicing factor 4 isoform b; rna-binding protein. [refseq;acc:nm_021164]	1	211.382	240.133	1.13601
202	serpin b11. [swissprot;acc:q96p15]	0	15123	16853	1.1144
	short transient receptor potential channel 4 (trpc4) (trp-related protein 4) (htrp-4) (htrp4). [swissprot;acc:q9ubn4]	1	228.784	201.478	1.13553
203	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]	0	15123	16853	1.1144
	ebp50-pdz interactor of 64 kda (epi64 protein). [swissprot;acc:q9bxi6]	1	228.752	201.515	1.13516
204	dipeptidyl peptidase 8 isoform 2; dipeptidyl peptidase 8. [refseq;acc:nm_017743]	0	16802.1	15081.8	1.11406
	short transient receptor potential channel 5 (trpc5) (htrp-5) (htrp5). [swissprot;acc:q9ul62]	1	228.752	201.515	1.13516
205	60s ribosomal protein l23a. [swissprot;acc:p29316]	0	10636.3	11844.9	1.11363
	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	1	200.968	228.1	1.13501
206	hepatitis c virus core-binding protein 6; cervical cancer oncogene 3. [refseq;acc:nm_023934]	0	6716	7479	1.11361
	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	1	201.006	228.085	1.13472
207	dc11 protein. [refseq;acc:nm_020186]	0	6716	7479	1.11361
	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	1	252.234	285.684	1.13261
208	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	0	10638.4	11846.3	1.11354
	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	1	252.234	285.684	1.13261
209	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]
	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	0	696	775	1.11351
210	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	1	252.234	285.684	1.13261
	mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362]	0	15405.6	17144.8	1.11289
211	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	1	252.234	285.684	1.13261
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	0	9320.25	10367	1.11231
212	cullin homolog 1 (cul-1). [swissprot;acc:q13616]	1	252.234	285.684	1.13261
	metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832]	0	16405	18241.7	1.11196
213	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]	1	186.95	210.693	1.127
	protein disulfide isomerase precursor (pdi) (ec 5.3.4.1) (prolyl 4- hydroxylase beta subunit) (cellular thyroid hormone binding protein) (p55). [swissprot;acc:p07237]	0	8436.39	9379.47	1.11179
214	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	1	170.192	191.644	1.12605
	probable glutamyl-trna(gln) amidotransferase subunit b, mitochondrial precursor (ec 6.3.5.-) (glu-adt subunit b) (cytochrome oxidase assembly factor pet112 homolog). [swissprot;acc:o75879]	0	8473.85	7621.99	1.11176
215	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	1	126	112	1.125
	myosin vi. [swissprot;acc:q9um54]	0	11250.5	10121.5	1.11154
216	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]		11732	10559.7	1.11102
	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	1	126	112	1.125
217	baculoviral iap repeat-containing protein 5 (apoptosis inhibitor survivin) (apoptosis inhibitor 4). [swissprot;acc:o15392]	0	6406.18	7101.79	1.10858
	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	1	126	112	1.125
218	lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893]	0	17469.2	19355	1.10795
	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	1	126	112	1.125
219	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]
	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040]	0	11009.7	12196.2	1.10777
220	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	1	126	112	1.125
	neurocalcin delta. [swissprot;acc:p29554]	0	15473.5	13973.6	1.10734
221	estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454]		13497.2	12190.3	1.10721
	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	1	126	112	1.125
222	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	0	11013.2	12183	1.10622
	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	1	126	112	1.125
223	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]
	pnas-18. [sptrembl;acc:q9bzu3]	0	13939.6	12602.7	1.10608
224	atp-dependent clp protease atp-binding subunit clpx-like, mitochondrial precursor. [swissprot;acc:o76031]		8889.93	9815.6	1.10413
	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	1	165.623	185.969	1.12285
225	40s ribosomal protein s29. [swissprot;acc:p30054]	0	9997.71	11035.3	1.10378
	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	1	201.769	226.471	1.12243

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.