MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 351 to 400 of 3730 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	description	Filtered	red	green	network_comparison
176	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]	0	13068	11528	1.13359
	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	1	275.754	235.908	1.1689
177	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]		229.406	196.695	1.1663
	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	0	14922.7	13174.5	1.1327
178	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	1	226.887	194.72	1.1652
	integral membrane protein cii-3b. [sptrembl;acc:o75609]	0	14951.6	13204.2	1.13234
179	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	1	226.884	194.79	1.16476
	mevalonate kinase (ec 2.7.1.36) (mk). [swissprot;acc:q03426]	0	9473.01	10723.7	1.13203
180	rna-binding protein nova-1 (neuro-oncological ventral antigen 1) (onconeural ventral antigen-1) (paraneoplastic ri antigen) (ventral neuron-specific protein 1). [swissprot;acc:p51513]		8407.67	9516.92	1.13193
	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	1	256.228	298.438	1.16474
181	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]		229.818	267.265	1.16294
	importin 7; ran-binding protein 7. [refseq;acc:nm_006391]	0	14864.7	16820.7	1.13159
182	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	1	277.546	240.461	1.15422
	putative inorganic polyphosphate/atp-nad kinase (ec 2.7.1.23) (poly(p)/atp nad kinase). [swissprot;acc:o95544]	0	11573.8	10231.3	1.13121
183	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	1	228.306	198.011	1.153
	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	0	11613	13133.5	1.13093
184	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	1	274.027	237.79	1.15239
	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]	0	6279.56	5569.42	1.12751
185	adiponectin receptor 2. [refseq;acc:nm_024551]	1	281.582	246.371	1.14292
	zinc finger protein 277. [swissprot;acc:q9nrm2]	0	6279.56	5569.42	1.12751
186	40s ribosomal protein s2 (s4) (llrep3 protein). [swissprot;acc:p15880]		11935.1	10592.8	1.12672
	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	1	226.582	198.444	1.14179
187	adenylosuccinate synthase-like 1. [refseq;acc:nm_152328]	0	9955.22	11213.7	1.12641
	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	1	226.582	198.444	1.14179
188	60s ribosomal protein l15. [swissprot;acc:p39030]	0	11745.2	13203.1	1.12413
	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	1	226.582	198.444	1.14179
189	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]
	sal-like protein 4 (zinc finger protein sall4). [swissprot;acc:q9ujq4]	0	10634.4	9465	1.12355
190	high-glucose-regulated protein 8 (ny-ren-2 antigen). [swissprot;acc:q9y5a9]		18809.5	16764.2	1.122
	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	1	226.582	198.444	1.14179
191	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]
	sh3 adapter protein spin90 (sh3 protein interacting with nck, 90 kda) (vaca-interacting protein, 54 kda) (vip54) (af3p21) (diaphanous protein interacting protein) (dia interacting protein-1) (dip-1). [swissprot;acc:q9nzq3]	0	18809.5	16764.2	1.122
192	musashi 2 isoform a. [refseq;acc:nm_138962]	1	227.491	199.458	1.14055
	t-complex protein 1, zeta subunit (tcp-1-zeta) (cct-zeta) (cct-zeta-1) (tcp20) (htr3). [swissprot;acc:p40227]	0	12715.9	11333.2	1.122
193	musashi 1. [refseq;acc:nm_002442]	1	227.491	199.458	1.14055
	transcription factor iiia (factor a) (tfiiia). [swissprot;acc:q92664]	0	10899.5	12217.4	1.12091
194	kappa b-ras 1. [refseq;acc:nm_020345]		12657.7	11299.1	1.12024
	nuclear protein ukp68. [refseq;acc:nm_024824]	1	227.491	199.458	1.14055
195	huntingtin interacting protein c. [refseq;acc:nm_012272]		227.971	200.417	1.13748
	mitochondrial 28s ribosomal protein s22 (s22mt) (mrp-s22) (gk002). [swissprot;acc:p82650]	0	13942.8	15586.4	1.11788
196	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	1	263.215	231.407	1.13745
	suppressor of ty 5 homolog; suppressor of ty (s.cerevisiae) 5 homolog. [refseq;acc:nm_003169]	0	11064.2	9897.84	1.11784
197	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	1	263.215	231.407	1.13745
	importin 4. [refseq;acc:nm_024658]	0	12337.6	13788.9	1.11763
198	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	1	263.191	231.394	1.13741
	ribosomal protein l10-like protein. [refseq;acc:nm_080746]	0	11781.5	10545.3	1.11723
199	60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]		11781.8	10545.7	1.11721
	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]	1	242.735	276.059	1.13729
200	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]		242.718	276.018	1.1372
	peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570]	0	8786.74	7870.3	1.11644

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.