Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 2530 to 2579 of 8289 in total
Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1
Rank
description
Interaction Map
red
green
network_comparison
1265 udp-n-acetylglucosamine--dolichyl-phosphate n- acetylglucosaminephosphotransferase (ec 2.7.8.15) (gpt) (g1pt) (n-acetylglucosamine-1-phosphate transferase) (glcnac-1-p transferase). [swissprot;acc:q9h3h5] High confidence 171.231 167.177 1.02425
1266 nadph:adrenodoxin oxidoreductase, mitochondrial precursor (ec 1.18.1.2) (adrenodoxin reductase) (ar) (ferredoxin-nadp(+) reductase). [swissprot;acc:p22570] Low confidence 201.264 196.834 1.02251
rho-gtpase-activating protein 7 (rho-type gtpase-activating protein 7) (deleted in liver cancer 1 protein) (dlc-1) (hp protein) (star-related lipid transfer protein 12) (stard12) (start domain-containing protein 12). [swissprot;acc:q96qb1] High confidence 171.231 167.177 1.02425
1267 map kinase-activated protein kinase 2 (ec 2.7.1.-) (mapk-activated protein kinase 2) (mapkap kinase 2) (mapkapk-2). [swissprot;acc:p49137]
testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610] Low confidence 203.672 199.189 1.02251
1268 histidyl-trna synthetase homolog (ec 6.1.1.21) (histidine--trna ligase homolog) (hisrs). [swissprot;acc:p49590] 192.905 188.658
neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825] High confidence 171.231 167.177 1.02425
1269 ectonucleoside triphosphate diphosphohydrolase 6 (ec 3.6.1.6) (ntpdase6) (cd39 antigen-like 2). [swissprot;acc:o75354] Low confidence 196.818 192.485 1.02251
nitrogen fixation cluster-like. [refseq;acc:nm_014301] High confidence 171.231 167.177 1.02425
1270 cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [swissprot;acc:p10635] Low confidence 201.858 197.415 1.02251
star-related lipid transfer protein 13 (stard13) (start domain- containing protein 13) (46h23.2). [swissprot;acc:q9y3m8] High confidence 171.231 167.177 1.02425
1271 histidyl-trna synthetase (ec 6.1.1.21) (histidine--trna ligase) (hisrs). [swissprot;acc:p12081] Low confidence 192.956 188.71 1.0225
star-related lipid transfer protein 8 (stard8) (start domain- containing protein 8). [swissprot;acc:q92502] High confidence 171.231 167.177 1.02425
1272 ceramide glucosyltransferase (ec 2.4.1.80) (glucosylceramide synthase) (gcs) (udp-glucose:n-acylsphingosine d-glucosyltransferase) (glct-1). [swissprot;acc:q16739] Low confidence 192.933 188.687 1.0225
neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822] High confidence 171.231 167.177 1.02425
1273 mitogen-activated protein kinase-activated protein kinase 3; mapkap kinase 3. [refseq;acc:nm_004635]
protein-tyrosine phosphatase, non-receptor type 2 (ec 3.1.3.48) (t- cell protein-tyrosine phosphatase) (tcptp). [swissprot;acc:p17706] Low confidence 200.744 196.329 1.02249
1274 cryptochrome 1 (photolyase-like). [refseq;acc:nm_004075] 193.539 189.282
mitogen-activated protein kinase 14 (ec 2.7.1.37) (mitogen-activated protein kinase p38alpha) (map kinase p38alpha) (cytokine suppressive anti-inflammatory drug binding protein) (csaid binding protein) (csbp) (max-interacting protein 2) (map kinase mxi2) (sapk2a). [swissprot;acc:q16539] High confidence 171.231 167.177 1.02425
1275 histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778] Low confidence 203.671 199.194 1.02248
neuronal acetylcholine receptor protein, alpha-4 chain precursor. [swissprot;acc:p43681] High confidence 171.231 167.177 1.02425
1276 histone h2b. [refseq;acc:nm_175055] Low confidence 203.671 199.194 1.02248
neuronal acetylcholine receptor protein, alpha-3 chain precursor. [swissprot;acc:p32297] High confidence 171.231 167.177 1.02425
1277 histone h2b.s (h2b/s). [swissprot;acc:p57053] Low confidence 203.671 199.194 1.02248
sphingosine kinase 2 (ec 2.7.1.-) (sk 2) (spk 2). [swissprot;acc:q9nra0] High confidence 171.231 167.177 1.02425
1278 histone h2b.e (h2b/e). [swissprot;acc:q99879] Low confidence 203.671 199.194 1.02248
sestrin 3. [swissprot;acc:p58005] High confidence 218.368 213.219 1.02415
1279 protein-tyrosine phosphatase, non-receptor type 1 (ec 3.1.3.48) (protein-tyrosine phosphatase 1b) (ptp-1b). [swissprot;acc:p18031] Low confidence 200.75 196.336 1.02248
sestrin 2 (hi95). [swissprot;acc:p58004] High confidence 218.368 213.219 1.02415
1280 cytochrome p450 4a11 precursor (ec 1.14.15.3) (cypiva11) (fatty acid omega-hydroxylase) (p-450 hk omega) (lauric acid omega-hydroxylase) (cyp4aii) (p450-hl-omega). [swissprot;acc:q02928] 213.22 1.02414
histone h2b.c (h2b/c). [swissprot;acc:q99880] Low confidence 203.672 199.196 1.02247
1281 cytochrome p450 4f3 (ec 1.14.13.30) (cypivf3) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:q08477] High confidence 218.368 213.22 1.02414
histone h2b.d (h2b/d). [swissprot;acc:q99877] Low confidence 203.671 199.195 1.02247
1282 connective tissue growth factor precursor (hypertrophic chondrocyte- specific protein 24). [swissprot;acc:p29279] 208.383 203.805 1.02246
cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187] High confidence 218.368 213.22 1.02414
1283 casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862] Low confidence 205.134 200.628 1.02246
likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033] High confidence 218.368 213.22 1.02414
1284 cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]
fumarylacetoacetase (ec 3.7.1.2) (fumarylacetoacetate hydrolase) (beta-diketonase) (faa). [swissprot;acc:p16930] Low confidence 202.294 197.852 1.02245
1285 cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329] High confidence 218.368 213.22 1.02414
prohibitin. [swissprot;acc:p35232] Low confidence 186.195 182.109 1.02244
1286 cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6] High confidence 218.368 213.22 1.02414
nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366] Low confidence 202.806 198.355 1.02244
1287 dj18d14.4 (cytochrome p450, subfamily iva, polypeptide 11). [sptrembl;acc:q9ntl5] High confidence 218.368 213.22 1.02414
long-chain-fatty-acid--coa ligase 3 (ec 6.2.1.3) (long-chain acyl-coa synthetase 3) (lacs 3). [swissprot;acc:o95573] Low confidence 201.127 196.714 1.02243
1288 cytochrome p450 4b1 (ec 1.14.14.1) (cypivb1) (p450-hp). [swissprot;acc:p13584] High confidence 218.368 213.22 1.02414
gc-rich sequence dna-binding factor homolog. [swissprot;acc:q9y5b6] Low confidence 204.236 199.757 1.02242
1289 flotillin-1. [swissprot;acc:o75955] High confidence 218.368 213.22 1.02414
zinc finger protein gli2 (tax helper protein). [swissprot;acc:p10070] Low confidence 203.073 198.619 1.02242
1290 protein phosphatase 1, regulatory (inhibitor) subunit 12b isoform a; myosin phosphatase regulatory subunit; myosin phosphatase, target subunit 2. [refseq;acc:nm_002481] 195.789 191.498 1.02241

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/