Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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description Rank Gene Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1551 to 1600 of 3228 in total
Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
description
Rank
red
green
network_comparison
lin-7 homolog a; vertebrate lin7 homolog 1; tax interaction protein 33; mammalian lin-7 1. [refseq;acc:nm_004664] 1372 5743.45 6193.45 1.07835
lin-7 homolog b; lin-7b protein; likely ortholog of mouse lin-7b; mammalian lin-7 protein 2; likely orholog of mouse lin 7 homolog b (c. elegans). [refseq;acc:nm_022165] 1388 5743.39 6192.94 1.07827
lin-7 homolog c; lin-7 protein 3. [refseq;acc:nm_018362] 1395 5743.26 6191.96 1.07813
lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (ec 2.3.1.-) (e2) (dihydrolipoamide branched chain transacylase) (bckad e2 subunit). [swissprot;acc:p11182] 1768 5829.61 6218.27 1.06667
lipoate-protein ligase, mitochondrial precursor (ec 6.-.-.-) (lipoate biosynthesis protein) (lipoyl ligase) (lipoyltransferase). [swissprot;acc:q9y234] 2389 6327.14 6579.38 1.03987
lipocalin-interacting membrane receptor. [refseq;acc:nm_018113] 1183 4392.63 4776.19 1.08732
lipoic acid synthetase, mitochondrial (lip-syn) (lipoate synthase) (hussy-01) (fragment). [swissprot;acc:o43766] 2508 6469.44 6634.31 1.02548
lipopolysaccharide-binding protein precursor (lbp). [swissprot;acc:p18428] 2334 5123.89 5350.78 1.04428
lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851] 2131 5328.73 5616.59 1.05402
liv-1 protein, estrogen regulated. [refseq;acc:nm_012319] 498 4682.87 4093.05 1.1441
loh1cr12. [refseq;acc:nm_058169] 842 5195.48 5741.63 1.10512
lon protease homolog, mitochondrial precursor (ec 3.4.21.-) (lon protease-like protein) (lonp) (lonhs). [swissprot;acc:p36776] 1598 5068.17 5430.41 1.07147
low affinity immunoglobulin epsilon fc receptor (lymphocyte ige receptor) (fc-epsilon-rii) (cd23) (blast-2) (immunoglobulin e-binding factor). [swissprot;acc:p06734] 2754 4521.42 4521.87 1.0001
luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019] 128 4355.61 5810.82 1.3341
luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032] 129 4358.13 5811.49 1.33348
lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455] 370 4108.15 4808.93 1.17058
lyl-1 protein (lymphoblastic leukemia derived sequence 1). [swissprot;acc:p12980] 3107 0.00001 0.00001 1
lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2] 891 5385.04 5933.65 1.10188
lysophospholipase i; lysophospholipase 1; lysophospholipid-specific lysophospholipase; acyl-protein thioesterase-1. [refseq;acc:nm_006330] 2017 6555.42 6938.82 1.05849
lysophospholipase ii; acyl-protein thioesterase. [refseq;acc:nm_007260] 2019
lysosomal acid lipase/cholesteryl ester hydrolase precursor (ec 3.1.1.13) (lal) (acid cholesteryl ester hydrolase) (sterol esterase) (lipase a) (cholesteryl esterase). [swissprot;acc:p38571] 1001 5680.76 6220.45 1.095
lysosomal alpha-mannosidase precursor (ec 3.2.1.24) (mannosidase, alpha b) (lysosomal acid alpha-mannosidase) (laman) (mannosidase alpha class 2b member 1). [swissprot;acc:o00754] 2677 7780.98 7741.14 1.00515
lysosomal trafficking regulator (beige homolog). [swissprot;acc:q99698] 2929 0.00001 0.00001 1
lysyl-trna synthetase (ec 6.1.1.6) (lysine--trna ligase) (lysrs). [swissprot;acc:q15046] 1808 4941.92 5265.09 1.06539
m-phase inducer phosphatase 1 (ec 3.1.3.48) (dual specificity phosphatase cdc25a). [swissprot;acc:p30304] 1896 4521 4805.16 1.06285
m-phase inducer phosphatase 2 (ec 3.1.3.48) (dual specificity phosphatase cdc25b). [swissprot;acc:p30305] 1989 4383.34 4642.93 1.05922
m-phase inducer phosphatase 3 (ec 3.1.3.48) (dual specificity phosphatase cdc25c). [swissprot;acc:p30307] 1940 4450.17 4721.37 1.06094
mab-21-like protein 1; mab-21-like 1. [refseq;acc:nm_005584] 2786 0.00001 0.00001 1
mab-21-like protein 2; mab-21-like 2. [refseq;acc:nm_006439] 2783
mad protein (max dimerizer). [swissprot;acc:q05195] 174 4455.95 5774.03 1.2958
mago nashi protein homolog. [swissprot;acc:p50606] 2864 0.00001 0.00001 1
maguk p55 subfamily member 2 (mpp2 protein) (discs, large homolog 2). [swissprot;acc:q14168] 2101 5241.34 5529.25 1.05493
maguk p55 subfamily member 3 (mpp3 protein) (discs, large homolog 3). [swissprot;acc:q13368] 987 6660.04 7301.81 1.09636
maguk p55 subfamily member 6 (veli-associated maguk 1) (vam-1). [swissprot;acc:q9nzw5] 2091 5247.76 5537.75 1.05526
major centromere autoantigen b (centromere protein b) (cenp-b). [swissprot;acc:p07199] 3013 0.00001 0.00001 1
malate dehydrogenase, cytoplasmic (ec 1.1.1.37). [swissprot;acc:p40925] 3213
malate dehydrogenase, mitochondrial precursor (ec 1.1.1.37). [swissprot;acc:p40926] 2400 4368.44 4539.34 1.03912
maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708] 2486 3626.38 3734.8 1.0299
malonyl-coa decarboxylase, mitochondrial precursor (ec 4.1.1.9) (mcd). [swissprot;acc:o95822] 1604 6176.82 6617.91 1.07141
mam domain containing glycosylphosphatidylinositol anchor 1; glycosyl-phosphatidyl-inositol-mam. [refseq;acc:nm_153487] 3070 0.00001 0.00001 1
mannose-6-phosphate isomerase (ec 5.3.1.8) (phosphomannose isomerase) (pmi) (phosphohexomutase). [swissprot;acc:p34949] 1719 5458.12 5830.76 1.06827
mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352] 884 5167.15 5695.44 1.10224
mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] 220 41482.5 33356.5 1.24361
map kinase-activated protein kinase 2 (ec 2.7.1.-) (mapk-activated protein kinase 2) (mapkap kinase 2) (mapkapk-2). [swissprot;acc:p49137] 475 9649.61 11053.5 1.14549
map/microtubule affinity-regulating kinase 1. [refseq;acc:nm_018650] 2586 4180.32 4253.46 1.0175
map/microtubule affinity-regulating kinase 2 isoform b; elkl motif kinase 1; elkl motif kinase. [refseq;acc:nm_004954] 2587
maspin precursor (protease inhibitor 5). [swissprot;acc:p36952] 2405 5078.5 5275.76 1.03884
mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088] 240 7711.36 6265.79 1.23071
mawd binding protein (unknown protein 32 from 2d-page of liver tissue). [swissprot;acc:p30039] 2018 6555.42 6938.82 1.05849
max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300] 177 4457.06 5773.63 1.29539

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/