MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	Value Type	description	Network Comparison Type	Filtered	Interaction Map	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 1051 to 1100 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Interaction Map	green	red	network_comparison
526	nnp-1 protein (novel nuclear protein 1) (nucleolar protein nop52) (nop52) (d21s2056e). [swissprot;acc:p56182]	High confidence	234.401	250.538	1.06884
	solute carrier family 2, facilitated glucose transporter, member 9 (glucose transporter type 9). [swissprot;acc:q9nrm0]	Low confidence	199.117	205.549	1.0323
527	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	High confidence	232.579	248.56	1.06871
	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	Low confidence	201.497	208.004	1.03229
528	solute carrier family 2, facilitated glucose transporter, member 2 (glucose transporter type 2, liver). [swissprot;acc:p11168]		199.115	205.543	1.03228
	yme1-like 1 isoform 3; atp-dependent metalloprotease ftsh1 homolog. [refseq;acc:nm_014263]	High confidence	237.393	222.146	1.06864
529	atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1]		235.506	251.653	1.06856
	zinc finger protein 183-like 1. [refseq;acc:nm_178861]	Low confidence	198.702	205.116	1.03228
530	solute carrier family 2, facilitated glucose transporter, member 3 (glucose transporter type 3, brain). [swissprot;acc:p11169]		199.114	205.541
	u6 snrna-associated sm-like protein lsm6 (sm protein f). [swissprot;acc:q9y4y8]	High confidence	212.994	227.483	1.06803
531	nuclear matrix protein nmp200 related to splicing factor prp19. [refseq;acc:nm_014502]		209.149	223.356	1.06793
	solute carrier family 2, facilitated glucose transporter, member 4 (glucose transporter type 4, insulin-responsive). [swissprot;acc:p14672]	Low confidence	199.114	205.54	1.03227
532	glucose transporter 14. [refseq;acc:nm_153449]		199.115	205.541
	zinc finger-like protein 9. [refseq;acc:nm_033414]	High confidence	235.004	250.942	1.06782
533	membrane-associated transporter protein (aim-1 protein) (melanoma antigen aim1). [swissprot;acc:q9umx9]
	solute carrier family 2, facilitated glucose transporter, member 1 (glucose transporter type 1, erythrocyte/brain) (hepg2 glucose transporter). [swissprot;acc:p11166]	Low confidence	199.112	205.533	1.03225
534	guanine nucleotide-binding protein-like 1 (gtp-binding protein hsr1). [swissprot;acc:p36915]	High confidence	235.004	250.942	1.06782
	zinc finger protein 216. [swissprot;acc:o76080]	Low confidence	178.613	184.361	1.03218
535	dna-directed rna polymerases i, ii, and iii 17.1 kda polypeptide (ec 2.7.7.6) (rpb17) (rpb8) (rpabc3). [swissprot;acc:p52434]	High confidence	252.708	236.662	1.0678
	protein associated with prk1. [refseq;acc:nm_019006]	Low confidence	178.613	184.361	1.03218
536	lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455]	High confidence	227.136	242.531	1.06778
	ran binding protein 9; novel centrosomal protein ranbpm; ran binding protein, centrosomal. [refseq;acc:nm_005493]	Low confidence	197.195	203.519	1.03207
537	megf11 protein. [refseq;acc:nm_032445]		201.517	207.951	1.03193
	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	High confidence	215.301	229.803	1.06736
538	dna-directed rna polymerase ii 7.6 kda polypeptide (ec 2.7.7.6) (rpb10) (rpb7.6) (rpabc5). [swissprot;acc:p52436]		253.604	237.627	1.06724
	megf10 protein. [refseq;acc:nm_032446]	Low confidence	201.517	207.949	1.03192
539	protein cgi-27 (c21orf19-like protein). [swissprot;acc:q9y316]	High confidence	252.86	236.964	1.06708
	protein x 0001. [refseq;acc:nm_016302]	Low confidence	193.489	199.661	1.0319
540	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	High confidence	208.201	222.156	1.06703
		Low confidence	200.027	206.406	1.03189
541	flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]	High confidence	208.201	222.156	1.06703
		Low confidence	200.027	206.406	1.03189
542	inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866]	High confidence	208.201	222.156	1.06703
		Low confidence	200.027	206.406	1.03189
543	selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]	High confidence	208.201	222.156	1.06703
		Low confidence	200.027	206.406	1.03189
544	inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]	High confidence	208.201	222.156	1.06703
		Low confidence	200.027	206.406	1.03189
545	c18b11 homolog (44.9kd). [refseq;acc:nm_152260]		196.678	202.949	1.03188
	eukaryotic translation initiation factor 6 (eif-6) (b4 integrin interactor) (cab) (p27(bbp)) (b(2)gcn homolog). [swissprot;acc:p56537]	High confidence	233.287	248.866	1.06678
546	wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]		194.262	207.222	1.06671
	z-protein (protein cgi-119) (s1r protein). [swissprot;acc:q9hc24]	Low confidence	196.678	202.949	1.03188
547	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]	High confidence	194.346	207.26	1.06645
	sestrin 3. [swissprot;acc:p58005]	Low confidence	197.023	203.305	1.03188
548	flotillin-1. [swissprot;acc:o75955]		197.022	203.303
	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]	High confidence	194.346	207.26	1.06645
549	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]
	sestrin 2 (hi95). [swissprot;acc:p58004]	Low confidence	197.024	203.306	1.03188
550	sestrin 1 (p53-regulated protein pa26). [swissprot;acc:q9y6p5]		197.018	203.299
	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]	High confidence	194.346	207.26	1.06645

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.