MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Filtered	Rank	Gene	Value Type	green	description	Network Comparison Type	network_comparison	Interaction Map	red

Results: HTML CSV LaTeX

Showing element 1051 to 1100 of 77072 in total

Filtered  : 0

Rank	Value Type	green	description	Network Comparison Type	network_comparison	Interaction Map	red
66	Squared	5963.73	tubulin gamma-1 chain (gamma-1 tubulin) (gamma-tubulin complex component 1) (gcp-1). [swissprot;acc:p23258]	Subtracted	2696.37	High confidence	8660.1
		57580.1	ariadne-2 protein homolog (ari-2) (triad1 protein) (ht005). [swissprot;acc:o95376]		3752.9	Low confidence	61333
	Rooted	6.55744	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]		6.55744	High confidence	0
		9.47365	dok-like protein. [refseq;acc:nm_024872]		4.77595	Low confidence	14.2496
		21.9983	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	Divided	1.40854	High confidence	30.9855
		26.828	elongation of very long chain fatty acids protein 2. [swissprot;acc:q9nxb9]		1.4185	Low confidence	18.9129
67	Measured	142.417	5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643]		1.89769		270.264
		898	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]		1.78508	High confidence	1603
		1971.25	similar to zinc finger protein 20 (zinc finger protein kox13) (dkfzp572p0920). [refseq;acc:nm_145233]	Subtracted	383.14	Low confidence	2354.39
		4320.09	purine nucleoside phosphorylase (ec 2.4.2.1) (inosine phosphorylase) (pnp). [swissprot;acc:p00491]		435.23	High confidence	4755.32
	Ranked	10324.5	protein kinase, lysine deficient 3. [refseq;acc:nm_020922]		2996	Low confidence	13320.5
		11823.3	purine nucleoside phosphorylase (ec 2.4.2.1) (inosine phosphorylase) (pnp). [swissprot;acc:p00491]		2890.74	High confidence	8932.56
		14291.5	presenilin enhancer 2; hematopoietic stem/progenitor cells protein mds033. [refseq;acc:nm_172341]	Divided	1.32408		10793.5
		14697.6	dynamin-like 120 kda protein, mitochondrial precursor (optic atrophy 1 gene protein). [swissprot;acc:o60313]		1.26309	Low confidence	11636.2
	Squared	15.2519	tyrosinase-related gene segment, exon 5 (fragment). [sptrembl;acc:q15677]		3.33542		50.8715
		190.865	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]		3.1865	High confidence	608.191
		3763.18	udp-glucuronosyltransferase 2b17 precursor, microsomal (ec 2.4.1.17) (udpgt) (c19-steroid specific udp-glucuronosyltransferase). [swissprot;acc:o75795]	Subtracted	2360.1		6123.28
		21426.5	solute carrier family 2, facilitated glucose transporter, member 11 (glucose transporter type 11) (glucose transporter type 10). [swissprot;acc:q9byw1]		3746.5	Low confidence	17680
	Rooted	12.9538	alpha 2 globin. [refseq;acc:nm_000517]	Divided	1.41698		18.3553
		14.4058	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	Subtracted	6.50517	High confidence	7.90063
		15.3166	isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252]	Divided	1.39177		11.0051
		21.1366	tenascin-x precursor (tn-x) (hexabrachion-like). [swissprot;acc:p22105]	Subtracted	4.681	Low confidence	16.4556
68	Measured	351.772	protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [refseq;acc:nm_003981]	Divided	1.76802	High confidence	198.964
		734	nadh-ubiquinone oxidoreductase mlrq subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-mlrq) (ci-mlrq). [swissprot;acc:o00483]		1.86294	Low confidence	394
		1971.25	zinc finger protein 222. [swissprot;acc:q9uk12]	Subtracted	383.14		2354.39
		6019.79	folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]		432.87	High confidence	6452.66
	Ranked	9824.6	repressor of estrogen receptor activity; b-cell associated protein. [refseq;acc:nm_007273]	Divided	1.25899	Low confidence	7803.58
		11823.3	purine nucleoside phosphorylase (ec 2.4.2.1) (inosine phosphorylase) (pnp). [swissprot;acc:p00491]		1.32362	High confidence	8932.56
		12378.5	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]	Subtracted	2929.23	Low confidence	9449.27
		17098	40s ribosomal protein s26. [swissprot;acc:p02383]		2828.3	High confidence	14269.7
	Squared	0.00001	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	Divided	3136000		31.36
		15.1833	5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643]		3.33538	Low confidence	50.642
		3763.18	udp-glucuronosyltransferase 2b11 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:o75310]	Subtracted	2360.1	High confidence	6123.28
		21397.2	solute carrier family 2, facilitated glucose transporter, member 5 (glucose transporter type 5, small intestine) (fructose transporter). [swissprot;acc:p22732]		3739.5	Low confidence	17657.7
	Rooted	8.63381	alpha crystallin a chain. [swissprot;acc:p02489]	Divided	1.38766	High confidence	6.22183
		12.9627	hemoglobin gamma-a and gamma-g chains. [swissprot;acc:p02096]		1.41651	Low confidence	18.3618
		18.9308	glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712]	Subtracted	4.6319		14.2989
		87.2238	polyadenylate-binding protein 3 (poly(a)-binding protein 3) (pabp 3) (testis-specific poly(a)-binding protein). [swissprot;acc:q9h361]		6.3871	High confidence	93.6109
69	Measured	70.5	tubulointerstitial nephritis antigen. [refseq;acc:nm_014464]	Divided	1.82979	Low confidence	129
		139	phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086]	Subtracted	431	High confidence	570
		1971.21	zinc finger protein 223. [swissprot;acc:q9uk11]		383.13	Low confidence	2354.34
		2804	dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]	Divided	1.7602	High confidence	1593
	Ranked	6909	nadh-ubiquinone oxidoreductase 13 kda-b subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-13kd-b) (ci-13kd-b) (complex i subunit b13). [swissprot;acc:q16718]	Subtracted	2921	Low confidence	9830
		10174.1	collagen alpha 5(iv) chain precursor. [swissprot;acc:p29400]	Divided	1.32051	High confidence	7704.7
		12610.3	transcription elongation factor a protein 1 (transcription elongation factor s-ii protein 1) (transcription elongation factor tfiis.o). [swissprot;acc:p23193]		1.25855	Low confidence	15870.7
		13464.8	elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897]	Subtracted	2825.9	High confidence	16290.7
	Squared	50.7408	protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [refseq;acc:nm_003981]	Divided	3.12432		16.2406
		253.857	tolloid-like 1. [refseq;acc:nm_012464]		3.26573	Low confidence	77.7335
		3763.18	udp-glucuronosyltransferase 2b4 precursor, microsomal (ec 2.4.1.17) (udpgt) (hyodeoxycholic acid) (hlug25) (udpgth-1). [swissprot;acc:p06133]	Subtracted	2360.1	High confidence	6123.28
		24333.8	ero1-like. [refseq;acc:nm_014584]		3722.2	Low confidence	20611.6

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.