Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene description Value Type Filtered Network Comparison Type green Interaction Map red network_comparison
Results: HTML CSV LaTeX Showing element 101 to 150 of 3730 in total
Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Rank
description
Filtered
green
red
network_comparison
51 neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90] 1 1390.33 779.167 1.78438
ribose-phosphate pyrophosphokinase iii (ec 2.7.6.1) (phosphoribosyl pyrophosphate synthetase iii) (prs-iii). [swissprot;acc:p21108] 0 88.5622 184.422 2.0824
52 chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557] 1 1390.33 779.167 1.78438
dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2] 0 481.725 999.28 2.07438
53 cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519] 1 1390.33 779.167 1.78438
muscle-specific beta 1 integrin binding protein. [refseq;acc:nm_014446] 0 861.814 420.365 2.05016
54 deltex 2. [refseq;acc:nm_020892] 1 2651.88 1618.84 1.63814
formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892] 0 330.189 638.862 1.93484
55 deltex homolog 1; hdx-1. [refseq;acc:nm_004416] 1 2662.12 1629.21 1.63399
huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404] 0 327.517 630.942 1.92644
56 t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492] 1 2664.55 1631.67 1.63302
tyrosinase-related gene segment, exon 5 (fragment). [sptrembl;acc:q15677] 0 142.981 271.484 1.89874
57 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643] 142.417 270.264 1.89769
kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558] 1 2664.55 1631.67 1.63302
58 40s ribosomal protein s26. [swissprot;acc:p02383] 0 81.2233 150.741 1.85588
kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559] 1 2664.55 1631.67 1.63302
59 f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755] 0 279.24 150.673 1.85328
kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688] 1 2664.55 1631.67 1.63302
60 1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446] 2765.82 4489.19 1.6231
adapter-related protein complex 1 sigma 1b subunit (sigma-adaptin 1b) (adaptor protein complex ap-1 sigma-1b subunit) (golgi adaptor ha1/ap1 adaptin sigma-1b subunit) (clathrin assembly protein complex 1 sigma- 1b small chain) (sigma 1b subunit of ap-1 clathrin) (dc22). [swissprot;acc:p56377] 0 87.5499 47.4756 1.8441
61 glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712] 593.094 324.442 1.82804
glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216] 1 2765.82 4489.19 1.6231
62 dipeptidyl peptidase 8 isoform 2; dipeptidyl peptidase 8. [refseq;acc:nm_017743] 0 384.407 210.767 1.82385
glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737] 1 2765.82 4489.19 1.6231
63 myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]
spir-2 protein (fragment). [sptrembl;acc:q8wwl2] 0 56.278 31.1429 1.80709
64 glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217] 1 2765.82 4489.19 1.6231
phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750] 0 18 0.00001 1800000
65 neuralized-like. [refseq;acc:nm_004210] 1 2690.25 1657.68 1.6229
rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372] 0 0.00001 18 1800000
66 nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09] 1 3221.38 1991.03 1.61795
soluble liver antigen/liver pancreas antigen. [refseq;acc:nm_153825] 0 385.626 688.436 1.78524
67 beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121] 1 10307.5 6475.5 1.59177
filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333] 0 898 1603 1.78508
68 beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407] 1 10307.5 6475.5 1.59177
protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [refseq;acc:nm_003981] 0 351.772 198.964 1.76802
69 dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0] 2804 1593 1.7602
spermatogenesis associated 6. [refseq;acc:nm_019073] 1 10307.5 6475.5 1.59177
70 amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]
importin alpha-2 subunit (karyopherin alpha-2 subunit) (srp1-alpha) (rag cohort protein 1). [swissprot;acc:p52292] 0 1068 607 1.75947
71 serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007] 1 2945.26 4556.78 1.54716
ubiquitin protein ligase. [refseq;acc:nm_130466] 0 352.75 620 1.75762
72 60s ribosomal protein l21. [swissprot;acc:p46778] 992.083 572 1.73441
uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48] 1 2945.28 4556.79 1.54715
73 protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236] 0 37.693 65.2968 1.73233
serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005] 1 2945.38 4556.83 1.54711
74 bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [swissprot;acc:p34820] 0 859.34 501.151 1.71473
serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4] 1 2945.8 4556.99 1.54694
75 nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181] 2907.43 1920.75 1.5137
oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977] 0 925.298 1586.07 1.71412

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/