MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Filtered	Gene	Rank	Value Type	description	Network Comparison Type	green	Interaction Map	network_comparison	red

Results: HTML CSV LaTeX

Showing element 1 to 50 of 3730 in total

Filtered  : 0
Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	description	green	network_comparison	red
1	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	15915	3.70633	4294
2	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	14977	2.55362	5865
3	nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8]	11083.9	2.47638	4475.84
4	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	21883	2.45711	8906
5	ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]	11965.7	2.17144	5510.5
6	ubiquitin protein ligase. [refseq;acc:nm_130466]	15339.2	2.03897	7523
7	cab2. [refseq;acc:nm_033419]	10950	1.99689	21866
8	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]	21888	1.89918	11525
9	transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]
10	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]	14178.1	1.88805	7509.39
11	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	6248	1.86092	11627
12	folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]	5208.84	1.81023	9429.18
13	heat shock 70 kda protein 1 (hsp70.1) (hsp70-1/hsp70-2). [swissprot;acc:p08107]	9264.5	1.77804	5210.5
14	dystrophin. [swissprot;acc:p11532]	18054.8	1.76446	10232.5
15	succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	11267	1.72211	19403
16	cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946]	20670.6	1.69839	12170.7
17	fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	6812	1.69451	11543
18	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	13216	1.68629	22286
19	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]
20	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]
21	acrc protein; putative nuclear protein. [refseq;acc:nm_052957]	10621.4	1.68236	6313.38
22	pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]	12479	1.68195	20989
23	hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712]	9285.44	1.67148	15520.4
24	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	8257	1.66289	13730.5
25	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]
26	dystrobrevin binding protein 1; dysbindin. [refseq;acc:nm_032122]	7533.33	1.60995	12128.3
27	ptd016 protein. [refseq;acc:nm_016125]	11234	1.60673	18050
28	p28 ing5. [refseq;acc:nm_032329]	7562.05	1.60337	12124.8
29	phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086]	11625	1.57201	7395
30	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]
31	leucine rich repeat (in flii) interacting protein 1. [refseq;acc:nm_004735]	5266.67	1.53462	8082.33
32	importin 9. [refseq;acc:nm_018085]	8691.76	1.52929	13292.2
33	nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733]
34	microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268]	17173.8	1.52196	11284
35	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	4871.6	1.5182	3208.8
36	guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]	14964	1.4984	22422
37	dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]	2582	1.49458	3859
38	cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]	10771	1.48976	7230
39	ero1-like. [refseq;acc:nm_014584]	20536	1.48242	13853
40	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	5699	1.48218	3845
41	60s ribosomal protein l21. [swissprot;acc:p46778]	6758.83	1.47871	9994.33
42	adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]	5530.5	1.47509	8158
43	glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712]	8356.02	1.4533	12143.8
44	serpin b12. [swissprot;acc:q96p63]	21138.6	1.44743	14604.2
45	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	21113.7	1.44694	14592
46	60s ribosomal protein l37a. [swissprot;acc:p12751]	18499.2	1.42943	12941.7
47	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]
48	nadh-ubiquinone oxidoreductase 13 kda-b subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-13kd-b) (ci-13kd-b) (complex i subunit b13). [swissprot;acc:q16718]	6909	1.42278	9830
49	brain protein 16. [refseq;acc:nm_016458]	4854.99	1.41927	6890.54
50	cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	13091.4	1.41533	9249.73

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.