Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Filtered Rank Gene description Value Type Network Comparison Type Interaction Map red network_comparison green
Results: HTML CSV LaTeX Showing element 1 to 50 of 3730 in total 
Filtered	0
Value Type	Ranked
Network Comparison Type	Divided
Interaction Map	High confidence

Rank	description	red	network_comparison	green	
1	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [source:swissprot;acc:q9np61]	4294	3.70633	15915	
2	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [source:swissprot;acc:q14849]	5865	2.55362	14977	
3	nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [source:swissprot;acc:q9gzt8]	4475.84	2.47638	11083.9	
4	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [source:swissprot;acc:q9y6g3]	8906	2.45711	21883	
5	ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [source:swissprot;acc:p55855]	5510.5	2.17144	11965.7	
6	ubiquitin protein ligase. [source:refseq;acc:nm_130466]	7523	2.03897	15339.2	
7	cab2. [source:refseq;acc:nm_033419]	21866	1.99689	10950	
8	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [source:swissprot;acc:q9bzk7]	11525	1.89918	21888	
9	transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [source:swissprot;acc:q9bq87]	11525	1.89918	21888	
10	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [source:swissprot;acc:o00757]	7509.39	1.88805	14178.1	
11	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [source:swissprot;acc:o75110]	11627	1.86092	6248	
12	folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [source:swissprot;acc:q05932]	9429.18	1.81023	5208.84	
13	heat shock 70 kda protein 1 (hsp70.1) (hsp70-1/hsp70-2). [source:swissprot;acc:p08107]	5210.5	1.77804	9264.5	
14	dystrophin. [source:swissprot;acc:p11532]	10232.5	1.76446	18054.8	
15	succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [source:swissprot;acc:o14521]	19403	1.72211	11267	
16	cyclin h (mo15-associated protein) (p37) (p34). [source:swissprot;acc:p51946]	12170.7	1.69839	20670.6	
17	fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [source:refseq;acc:nm_013402]	11543	1.69451	6812	
18	homeobox protein hox-c4 (hox-3e) (cp19). [source:swissprot;acc:p09017]	22286	1.68629	13216	
19	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [source:swissprot;acc:p09630]	22286	1.68629	13216	
20	homeobox protein hox-a4 (hox-1d) (hox-1.4). [source:swissprot;acc:q00056]	22286	1.68629	13216	
21	acrc protein; putative nuclear protein. [source:refseq;acc:nm_052957]	6313.38	1.68236	10621.4	
22	pyridoxine 5'-phosphate oxidase. [source:refseq;acc:nm_018129]	20989	1.68195	12479	
23	hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [source:refseq;acc:nm_004712]	15520.4	1.67148	9285.44	
24	ba508n22.1 (hspc025) (fragment). [source:sptrembl;acc:q9hcw5]	13730.5	1.66289	8257	
25	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [source:swissprot;acc:p50851]	13730.5	1.66289	8257	
26	dystrobrevin binding protein 1; dysbindin. [source:refseq;acc:nm_032122]	12128.3	1.60995	7533.33	
27	ptd016 protein. [source:refseq;acc:nm_016125]	18050	1.60673	11234	
28	p28 ing5. [source:refseq;acc:nm_032329]	12124.8	1.60337	7562.05	
29	phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [source:swissprot;acc:p11086]	7395	1.57201	11625	
30	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [source:refseq;acc:nm_031938]	7395	1.57201	11625	
31	leucine rich repeat (in flii) interacting protein 1. [source:refseq;acc:nm_004735]	8082.33	1.53462	5266.67	
32	importin 9. [source:refseq;acc:nm_018085]	13292.2	1.52929	8691.76	
33	nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [source:swissprot;acc:q99733]	13292.2	1.52929	8691.76	
34	microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [source:refseq;acc:nm_014268]	11284	1.52196	17173.8	
35	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [source:refseq;acc:nm_006333]	3208.8	1.5182	4871.6	
36	guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [source:swissprot;acc:q9byb4]	22422	1.4984	14964	
37	dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [source:sptrembl;acc:q9uge0]	3859	1.49458	2582	
38	cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [source:swissprot;acc:p49336]	7230	1.48976	10771	
39	ero1-like. [source:refseq;acc:nm_014584]	13853	1.48242	20536	
40	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [source:swissprot;acc:p21333]	3845	1.48218	5699	
41	60s ribosomal protein l21. [source:swissprot;acc:p46778]	9994.33	1.47871	6758.83	
42	adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [source:swissprot;acc:p12236]	8158	1.47509	5530.5	
43	glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [source:swissprot;acc:p30712]	12143.8	1.4533	8356.02	
44	serpin b12. [source:swissprot;acc:q96p63]	14604.2	1.44743	21138.6	
45	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [source:swissprot;acc:q9uiv8]	14592	1.44694	21113.7	
46	60s ribosomal protein l37a. [source:swissprot;acc:p12751]	12941.7	1.42943	18499.2	
47	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [source:swissprot;acc:o15528]	12941.7	1.42943	18499.2	
48	nadh-ubiquinone oxidoreductase 13 kda-b subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-13kd-b) (ci-13kd-b) (complex i subunit b13). [source:swissprot;acc:q16718]	9830	1.42278	6909	
49	brain protein 16. [source:refseq;acc:nm_016458]	6890.54	1.41927	4854.99	
50	cartilage oligomeric matrix protein precursor (comp). [source:swissprot;acc:p49747]	9249.73	1.41533	13091.4	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/