MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	description	Value Type	Rank	Filtered	Network Comparison Type	Interaction Map	network_comparison	green	red

Results: HTML CSV LaTeX

Showing element 3180 to 3229 of 3730 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence

description	Rank	Filtered	network_comparison	green	red
swi/snf-related matrix-associated actin-dependent regulator of chromatin c2 isoform a; mammalian chromatin remodeling complex brg1-associated factor 170; chromatin remodeling complex baf170 subunit; swi3-like protein; swi/snf complex 170 kda subunit. [refseq;acc:nm_003075]	2619	1	1.00137	219.722	220.024
swi/snf-related matrix-associated actin-dependent regulator of chromatin d2; rsc6p; mammalian chromatin remodeling complex brg1-associated factor 60b; swp73-like protein; chromatin remodeling complex baf60b subunit; swi/snf complex 60 kda subunit b. [refseq;acc:nm_003077]	2512		1.00241	234.948	234.384
swi/snf-related matrix-associated actin-dependent regulator of chromatin d3; rsc6p; mammalian chromatin remodeling complex brg1-associated factor 60c; swp73-like protein; chromatin remodeling complex baf60c subunit; swi/snf complex 60 kda subunit c. [refseq;acc:nm_003078]	2513
swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]	941		1.03586	205.083	212.437
symplekin. [swissprot;acc:q92797]	2203		1.00651	163.8	162.741
synapsin i (brain protein 4.1). [swissprot;acc:p17600]	669		1.0577	216.576	229.072
synapsin ii. [swissprot;acc:q92777]	662
synapsin iii. [swissprot;acc:o14994]	657
synaptosomal-associated protein 29 (snap-29) (vesicle-membrane fusion protein snap-29) (soluble 29 kda nsf attachment protein). [swissprot;acc:o95721]	814		1.04425	221.785	212.386
synaptotagmin xii (sytxii). [swissprot;acc:q8iv01]	2351		1.00438	213.289	214.223
synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	56	0	1.36929	16388	22440
	566	1	1.06563	121.261	129.219
syndecan-3 (synd3). [swissprot;acc:o75056]	2862		1	0.00001	0.00001
syntaxin 10 (syn10). [swissprot;acc:o60499]	54	0	1.36949	19014.6	13884.4
	354	1	1.09694	257.442	234.691
syntaxin 12. [refseq;acc:nm_177424]	858		1.04043	208.997	217.446
syntaxin 16 (syn16). [swissprot;acc:o14662]	809		1.04425	221.785	212.386
syntaxin 18. [swissprot;acc:q9p2w9]	237		1.11785	254.15	227.357
syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623]	84	0	1.26647	15781	12460.6
	811	1	1.04425	221.785	212.386
syntaxin 1b. [swissprot;acc:q15531]	815
syntaxin 5. [swissprot;acc:q13190]	2866		1	0.00001	0.00001
syntaxin 6. [swissprot;acc:o43752]	355		1.09691	257.414	234.673
syntaxin 7. [swissprot;acc:o15400]	890		1.03908	209.012	217.181
t-box transcription factor tbx1 (t-box protein 1) (testis-specific t-box protein). [swissprot;acc:o43435]	2771		1	0.00001	0.00001
t-box transcription factor tbx19 (t-box protein 19). [swissprot;acc:o60806]	2042		1.00854	208.803	210.586
t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	434		1.07934	229.411	212.547
t-cell activation wd repeat protein. [refseq;acc:nm_139281]	976		1.03407	235.322	243.34
t-cell acute lymphocytic leukemia-1 protein (tal-1 protein) (stem cell protein) (t-cell leukemia/lymphoma-5 protein). [swissprot;acc:p17542]	2865		1	0.00001	0.00001
t-cell acute lymphocytic leukemia-2 protein (tal-2 protein). [swissprot;acc:q16559]	2760
t-cell leukemia homeobox protein 1 (homeobox protein hox-11) (tcl-3 proto-oncogene). [swissprot;acc:p31314]	585		1.06411	252.492	237.28
t-cell leukemia homeobox protein 2 (homeobox protein hox-11l1) (neural crest homeobox protein). [swissprot;acc:o43763]	584
t-cell leukemia homeobox protein 3 (homeobox protein hox-11l2). [swissprot;acc:o43711]	581
t-complex 11. [refseq;acc:nm_018679]	1741		1.01289	209.258	206.595
t-complex associated-testis-expressed 1-like (protein 91/23). [swissprot;acc:p51808]	1044		1.03121	178.889	173.475
t-complex protein 1, alpha subunit (tcp-1-alpha) (cct-alpha). [swissprot;acc:p17987]	689		1.05579	128.225	135.379
t-complex protein 1, delta subunit (tcp-1-delta) (cct-delta) (stimulator of tar rna binding). [swissprot;acc:p50991]	285		1.10532	203.242	224.647
t-complex protein 1, epsilon subunit (tcp-1-epsilon) (cct-epsilon). [swissprot;acc:p48643]	1040		1.03136	168.359	163.24
t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	397		1.08932	101.613	110.689
t-complex protein 1, zeta subunit (tcp-1-zeta) (cct-zeta) (cct-zeta-1) (tcp20) (htr3). [swissprot;acc:p40227]	192	0	1.122	11333.2	12715.9
	2917	1	1	0.00001	0.00001
t-complex protein 1, zeta-2 subunit (tcp-1-zeta-2) (cct-zeta-2) (tcp- 1-zeta-like) (cct-zeta-like) (testis-specific tcp20) (testis-specific protein tsa303). [swissprot;acc:q92526]	2995
t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	112		1.24557	267.246	332.874
t54 protein. [swissprot;acc:q92917]	569		1.06554	212.38	226.3
tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	180		1.16474	298.438	256.228
target of egr1, member 1 (nuclear); target of egr1, member 1. [refseq;acc:nm_025077]	1017		1.03233	210.558	217.365
target of myb protein 1. [swissprot;acc:o60784]	948		1.03541	209.824	217.254
target of myb1-like 2; target of myb1 (chicken) homolog-like 2. [refseq;acc:nm_144678]	952		1.03537	209.83	217.252
tata box binding protein (transcription initiation factor tfiid) (tata-box factor) (tata sequence-binding protein) (tbp). [swissprot;acc:p20226]	2267		1.00561	210.416	211.597
tata box binding protein-associated factor, rna polymerase ii, q; taf7-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 50 kd; tbp-associated factor, rna polymerase ii, q. [refseq;acc:nm_024885]	382		1.09328	183.66	200.791

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.