Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Filtered Gene Value Type Rank Network Comparison Type red Interaction Map description network_comparison green
Results: HTML CSV LaTeX Showing element 501 to 550 of 19268 in total
Filtered  : 0
Value Type  : Ranked
Rank
Network Comparison Type
red
Interaction Map
description
network_comparison
green
126 Divided 9722.71 High confidence ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858] 1.18216 11493.8
14899.4 Low confidence bromodomain adjacent to zinc finger domain protein 1a (atp-utilizing chromatin assembly and remodeling factor 1) (hacf1) (atp-dependent chromatin remodelling protein) (williams syndrome transcription factor-related chromatin remodeling factor 180) (wcrf180) (hwalp1) (chrac subunit acf1) (hspc317). [swissprot;acc:q9nrl2] 1.17872 17562.2
Subtracted 12314.9 High confidence cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329] 1825.6 10489.3
15945.5 Low confidence putative protein-tyrosine phosphatase tpte (ec 3.1.3.48). [swissprot;acc:p56180] 1822.2 14123.3
127 Divided 9411.34 High confidence trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317] 1.18152 11119.7
10041.1 Low confidence scribble. [refseq;acc:nm_015356] 1.1766 11814.4
Subtracted 11732 High confidence ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1] 1798.6 13530.6
16660.8 Low confidence dna helicase homolog (fragment). [sptrembl;acc:q9y645] 1814.7 18475.5
128 Divided 9259.51 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8] 1.17496 10879.6
11564.4 High confidence 60s ribosomal protein l39. [swissprot;acc:p02404] 1.18073 9794.29
Subtracted 9722.71 ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858] 1771.09 11493.8
11161.3 Low confidence lifeguard; kiaa0950 protein. [refseq;acc:nm_012306] 1804.2 12965.5
129 Divided 9248.93 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150] 1.17478 10865.5
14222.5 High confidence isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252] 1.17945 12058.6
Subtracted 11564.4 60s ribosomal protein l39. [swissprot;acc:p02404] 1770.11 9794.29
13206.7 Low confidence piwi-like 2; miwi like. [refseq;acc:nm_018068] 1801.4 15008.1
130 Divided 14476.2 High confidence enigma protein; lim domain protein. [refseq;acc:nm_005451] 1.17914 17069.5
16024.9 Low confidence sedlin. [swissprot;acc:o14582] 1.17433 13646
Subtracted 10041.1 scribble. [refseq;acc:nm_015356] 1773.3 11814.4
14922.7 High confidence potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] 1748.2 13174.5
131 Divided 4793.5 Low confidence mitochondrial 39s ribosomal protein l39 (l39mt) (mrp-l39) (mrp-l5) (pred22 protein). [swissprot;acc:q9nyk5] 1.17013 5609
8375.43 High confidence dna mismatch repair protein mlh1 (mutl protein homolog 1). [swissprot;acc:p40692] 1.17887 9873.58
Subtracted 14951.6 integral membrane protein cii-3b. [sptrembl;acc:o75609] 1747.4 13204.2
15039.8 Low confidence transcription factor bteb4 (basic transcription element binding- protein 4) (bte-binding protein 4) (krueppel-like factor 16) (novel sp1-like zinc finger transcription factor 2) (transcription factor nslp2). [swissprot;acc:q9bxk1] 1762.2 13277.6
132 Divided 16411.9 mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] 1.17001 14027.1
19048 High confidence rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372] 1.1754 22389
Subtracted 10883 myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1] 1739.8 12622.8
12716.5 Low confidence glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712] 1754.1 10962.4
133 Divided 6814 High confidence alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7] 1.17537 8009
11236.1 Low confidence alpha-amylase, salivary precursor (ec 3.2.1.1) (1,4-alpha-d-glucan glucanohydrolase). [swissprot;acc:p04745] 1.16709 13113.5
Subtracted 14922.7 potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] 1748.2 13174.5
17144.8 High confidence mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362] 1739.2 15405.6
134 Divided 9210.38 Low confidence sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626] 1.1669 7893.05
12314.9 High confidence cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187] 1.17404 10489.3
Subtracted 12157.6 signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458] 1732.7 13890.3
16853 Low confidence maspin precursor (protease inhibitor 5). [swissprot;acc:p36952] 1730 15123
135 Divided 12314.9 High confidence cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329] 1.17404 10489.3
15432.9 Low confidence phosphatidylinositol 4-kinase alpha (ec 2.7.1.67) (pi4-kinase) (ptdins-4-kinase) (pi4k-alpha). [swissprot;acc:p42356] 1.16475 13250
Subtracted 8871.11 High confidence bloom's syndrome protein (ec 3.6.1.-) (recq protein-like 3) (dna helicase, recq-like, type 2). [swissprot;acc:p54132] 1732.09 10603.2
16853 Low confidence serpin b11. [swissprot;acc:q96p15] 1730 15123
136 Divided 12024.2 signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458] 1.16242 13977.2
12335.3 High confidence cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2] 1.17403 10506.8
Subtracted 12759.4 polyposis locus protein 1-like 1; likely ortholog of mouse polyposis locus protein 1-like 1. [refseq;acc:nm_138393] 1730.6 11028.8
16853 Low confidence cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452] 1730 15123
137 Divided 11161.3 lifeguard; kiaa0950 protein. [refseq;acc:nm_012306] 1.16165 12965.5
12328.5 High confidence cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6] 1.17403 10501
Subtracted 16853 maspin precursor (protease inhibitor 5). [swissprot;acc:p36952] 1730 15123
19314 Low confidence homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099] 1727 21041
138 Divided 8730 zinc finger protein-like 1; zinc-finger protein in men1 region. [refseq;acc:nm_006782] 1.16152 7516
12384.7 High confidence likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033] 1.17397 10549.4

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/