MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Rank	description	Value Type	Interaction Map	Network Comparison Type	red	Filtered	network_comparison	green

Results: HTML CSV LaTeX

Showing element 551 to 600 of 12912 in total

Interaction Map  : High confidence
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Value Type	red	network_comparison	green
138	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Squared	468498	1.45156	322755
	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	Ranked	194.372	1.20493	234.204
139	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]		271.752	1.20415	225.68
	g2/mitotic-specific cyclin b2. [swissprot;acc:o95067]	Squared	81592.1	1.45153	56211.1
	nuclear protein ukp68. [refseq;acc:nm_024824]	Rooted	54.9787	1.20486	66.2416
	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	Measured	2759.61	1.31442	2099.49
140	cell division protein kinase 2 (ec 2.7.1.-) (p33 protein kinase). [swissprot;acc:p24941]	Squared	81527.6	1.45091	56190.6
	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	Rooted	55.6161	1.19989	66.7332
	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	Measured	2760.28	1.31425	2100.27
	ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570]	Ranked	59	1.20408	49
141	g2/mitotic-specific cyclin b1. [swissprot;acc:p14635]	Squared	81520.8	1.45084	56188.5
	ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157]	Ranked	59	1.20408	49
	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	Rooted	55.6161	1.19989	66.7332
	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	Measured	4405.4	1.3125	5782.08
142	cell division control protein 2 homolog (ec 2.7.1.-) (p34 protein kinase) (cyclin-dependent kinase 1) (cdk1). [swissprot;acc:p06493]	Squared	81478.9	1.45044	56175.2
	metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889]	Measured	9276.47	1.30832	7090.37
	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	Rooted	55.6161	1.19989	66.7332
	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	Ranked	59	1.20408	49
143	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]
	beta-1,4 mannosyltransferase. [refseq;acc:nm_019109]	Measured	9275.1	1.30826	7089.65
	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]	Rooted	55.6161	1.19989	66.7332
	protein phosphatase 1, regulatory (inhibitor) subunit 13b; apoptosis-stimulating protein of p53, 1. [refseq;acc:nm_015316]	Squared	124319	1.43145	86848.2
144	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	Ranked	265.686	1.20312	319.651
	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	Measured	3349.9	1.30231	4362.61
	tumor suppressor p53-binding protein 2 (p53-binding protein 2) (53bp2) (bcl2-binding protein) (bbp). [swissprot;acc:q13625]	Squared	123324	1.42938	86277.9
	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	Rooted	55.6161	1.19989	66.7332
145	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Squared	310840	1.42515	442993
	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	Ranked	265.639	1.20293	319.546
	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	Measured	16771.5	1.30122	12889.1
146	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]		11068	1.30082	8508.5
	huntingtin interacting protein c. [refseq;acc:nm_012272]	Rooted	55.0737	1.19894	66.0298
	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	Ranked	265.632	1.20291	319.531
	ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570]	Squared	103496	1.41888	146848
147	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	Rooted	42.0574	1.19893	50.4237
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Ranked	50.7983	1.2009	42.3003
	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	Measured	11068	1.30082	8508.5
	ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157]	Squared	103496	1.41888	146848
148	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	Measured	11068	1.30082	8508.5
	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	Rooted	42.0577	1.19892	50.424
	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	Squared	103496	1.41888	146848
	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	Ranked	296.677	1.19841	247.559
149	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	Squared	103496	1.41888	146848
	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	Ranked	142	1.19718	170
	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	Rooted	42.0684	1.19882	50.4323
	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	Measured	11068	1.30082	8508.5
150	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	Ranked	55	1.19565	46
	pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989]	Squared	121200	1.41799	85473.4
	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	Measured	11068	1.30082	8508.5
	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	Rooted	63.5827	1.19774	53.0856

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.