Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene Value Type description Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1051 to 1100 of 8289 in total
Value Type  : Measured
Network Comparison Type  : Divided
Filtered  : 1
Rank
description
Interaction Map
red
green
network_comparison
526 aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181] High confidence 10639.9 12117.4 1.13886
mitochondrial 2-oxodicarboxylate carrier. [swissprot;acc:q9bqt8] Low confidence 8808.17 9227.11 1.04756
527 nuclear factor, interleukin 3 regulated. [refseq;acc:nm_005384] 8208.19 8598.61
protein phosphatase 2c beta isoform (ec 3.1.3.16) (pp2c-beta). [swissprot;acc:o75688] High confidence 4775.11 5438.18 1.13886
528 aquaporin-chip (water channel protein for red blood cells and kidney proximal tubule) (aquaporin 1) (aqp-1) (urine water channel). [swissprot;acc:p29972] 10635.3 12111.4 1.13879
cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642] Low confidence 7995.2 8373.8 1.04735
529 mitochondrial import receptor subunit tom20 homolog (mitochondrial 20 kda outer membrane protein) (outer mitochondrial membrane receptor tom20). [swissprot;acc:q15388] High confidence 8600.02 9792.49 1.13866
peroxisomal targeting signal 2 receptor (pts2 receptor) (peroxin-7). [swissprot;acc:o00628] Low confidence 8475.71 8876.05 1.04723
530 peroxisomal farnesylated protein (33 kda housekeeping protein) (peroxin 19). [swissprot;acc:p40855] High confidence 8600.02 9792.49 1.13866
ubiquitin-conjugating enzyme e2 c (ec 6.3.2.19) (ubiquitin-protein ligase c) (ubiquitin carrier protein c) (ubch10). [swissprot;acc:o00762] Low confidence 8114.7 8497.85 1.04722
531 stip1 homology and u-box containing protein 1; serologically defined colon cancer antigen 7; carboxy terminus of hsp70p-interacting protein; heat shock protein a binding protein 2 (c-terminal). [refseq;acc:nm_005861] 7913.91 8287.57
transcription initiation factor iib (general transcription factor tfiib) (s300-ii). [swissprot;acc:q00403] High confidence 4651.88 5296.78 1.13863
532 heterogeneous nuclear ribonucleoprotein h3 (hnrnp h3) (hnrnp 2h9). [swissprot;acc:p31942] Low confidence 7295.46 7639.5 1.04716
thyroid receptor interacting protein 3 (trip-3) (fragment). [swissprot;acc:q15649] High confidence 4651.88 5296.78 1.13863
533 nhp2-like protein 1 (high mobility group-like nuclear protein 2 homolog 1) ([u4/u6.u5] tri-snrnp 15.5 kda protein) (otk27). [swissprot;acc:p55769]
syntaxin 5. [swissprot;acc:q13190] Low confidence 8784.44 9198.67 1.04715
534 nuclear fragile x mental retardation protein interacting protein 1; nuclear fragile x mental retardation intercating protein 1; nuclear fragile x mental retardation protein-interacting protein 1. [refseq;acc:nm_012345] High confidence 4651.88 5296.78 1.13863
nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952] Low confidence 7384.69 7732.55 1.04711
535 f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755] 7502.59 7855.86 1.04709
translocon-associated protein, delta subunit precursor (trap-delta) (signal sequence receptor delta subunit) (ssr-delta). [swissprot;acc:p51571] High confidence 10603.5 12069.5 1.13826
536 calsyntenin-1 precursor. [swissprot;acc:o94985]
iap-associated factor viaf1; phosducin-like 2. [refseq;acc:nm_024065] Low confidence 7994.42 8370.84 1.04709
537 succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521] High confidence 10603.5 12069.5 1.13826
williams beuren syndrome chromosome region 21 isoform 1. [refseq;acc:nm_148912] Low confidence 7994.42 8370.8 1.04708
538 heterogeneous nuclear ribonucleoprotein h (hnrnp h). [swissprot;acc:p31943] 7301.04 7644.09 1.04699
protein-tyrosine phosphatase beta precursor (ec 3.1.3.48) (r-ptp- beta). [swissprot;acc:p23467] High confidence 10603.5 12069.4 1.13825
539 ba138e2.1.2 (formin-binding protein 17 (fbp17), isoform 2). [sptrembl;acc:q96lh6] Low confidence 7993.53 8368.97 1.04697
thymus-specific serine protease precursor (ec 3.4.-.-). [swissprot;acc:q9nqe7] High confidence 10603.5 12069.4 1.13825
540 gk001 protein. [refseq;acc:nm_020198]
pre-mrna splicing factor prp17 (hprp17) (eh-binding protein 3) (ehb3). [swissprot;acc:o60508] Low confidence 7937.69 8310.27 1.04694
541 calsyntenin-2 precursor. [swissprot;acc:q9h4d0] High confidence 10600.3 12065.2 1.13819
dnaj homolog subfamily a member 4. [swissprot;acc:q8ww22] Low confidence 8574.98 8976.82 1.04686
542 heterogeneous nuclear ribonucleoprotein h' (hnrnp h') (ftp-3). [swissprot;acc:p55795] 7305.05 7647.16 1.04683
rac-alpha serine/threonine kinase (ec 2.7.1.-) (rac-pk-alpha) (protein kinase b) (pkb) (c-akt). [swissprot;acc:p31749] High confidence 3889.27 4426.74 1.13819
543 calsyntenin-3 precursor. [swissprot;acc:q9bqt9] 10599.9 12064.7
phosphatidylinositol 4-kinase type-ii beta; likely ortholog of mouse phosphatidylinositol 4-kinase type 2 beta. [refseq;acc:nm_018323] Low confidence 8159.4 8541.33 1.04681
544 pp1201 protein. [refseq;acc:nm_022152] 7723.74 8085.19 1.0468
rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243] High confidence 3889.27 4426.74 1.13819
545 phosphatidylinositol 4-kinase type ii. [refseq;acc:nm_018425] Low confidence 8159.25 8540.75 1.04676
rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751] High confidence 3889.27 4426.74 1.13819
546 adenylosuccinate synthetase (ec 6.3.4.4) (imp--aspartate ligase) (adss) (ampsase). [swissprot;acc:p30520] Low confidence 8451.27 8845.91 1.0467
zinc finger protein t86. [swissprot;acc:o00488] High confidence 4052.77 4612.54 1.13812
547 small glutamine rich protein with tetratricopeptide repeats 2. [refseq;acc:nm_019072] Low confidence 8727.92 9135.42 1.04669
werner helicase interacting protein isoform 1; putative helicase ruvbl; werner helicase interacting protein. [refseq;acc:nm_020135] High confidence 5291.92 6020.19 1.13762
548 adenylosuccinate synthase-like 1. [refseq;acc:nm_152328] Low confidence 8447.46 8841.77 1.04668
adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109] High confidence 8268.19 9405.85 1.13759
549 dolichol-phosphate mannosyltransferase (ec 2.4.1.83) (dolichol- phosphate mannose synthase) (dolichyl-phosphate beta-d- mannosyltransferase) (mannose-p-dolichol synthase) (mpd synthase) (dpm synthase). [swissprot;acc:o60762] 5865.79 6671.23 1.13731
imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549] Low confidence 7823.38 8187.78 1.04658
550 cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187] 8132.78 8511.5 1.04657
prohibitin. [swissprot;acc:p35232] High confidence 5773.45 6563.69 1.13687

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/