MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	description	Value Type	Network Comparison Type	Filtered	Interaction Map	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 951 to 1000 of 3730 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	description	Filtered	red	network_comparison	green
476	dead/h (asp-glu-ala-asp/his) box polypeptide 11; dead/h box-11 (chl1-related helicase gene-1); yeast chl1 homolog. [refseq;acc:nm_030655]	0	1362.55	1.00716	1372.31
	neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825]	1	9649.61	1.14549	11053.5
477	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	0	426	1.00704	429
	nitrogen fixation cluster-like. [refseq;acc:nm_014301]	1	9649.61	1.14549	11053.5
478	star-related lipid transfer protein 13 (stard13) (start domain- containing protein 13) (46h23.2). [swissprot;acc:q9y3m8]
	survival motor neuron protein (component of gems 1) (gemin1). [swissprot;acc:q16637]	0	705.758	1.00669	701.071
479	adenylosuccinate synthase-like 1. [refseq;acc:nm_152328]		1318.37	1.00587	1310.67
	star-related lipid transfer protein 8 (stard8) (start domain- containing protein 8). [swissprot;acc:q92502]	1	9649.61	1.14549	11053.5
480	neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822]
	orphan nuclear receptor nr2e1 (nuclear receptor tlx) (tailless homolog) (tll) (htll). [swissprot;acc:q9y466]	0	6428	1.00488	6396.8
481	mitogen-activated protein kinase kinase kinase 5 (ec 2.7.1.-) (mapk/erk kinase kinase 5) (mek kinase 5) (mekk 5) (apoptosis signal- regulating kinase 1) (ask-1). [swissprot;acc:q99683]		565.785	1.00475	563.113
	mitogen-activated protein kinase-activated protein kinase 3; mapkap kinase 3. [refseq;acc:nm_004635]	1	9649.61	1.14549	11053.5
482	mitogen-activated protein kinase 14 (ec 2.7.1.37) (mitogen-activated protein kinase p38alpha) (map kinase p38alpha) (cytokine suppressive anti-inflammatory drug binding protein) (csaid binding protein) (csbp) (max-interacting protein 2) (map kinase mxi2) (sapk2a). [swissprot;acc:q16539]
	sprouty homolog 4 (spry-4). [swissprot;acc:q9c004]	0	793.778	1.00387	796.85
483	neuronal acetylcholine receptor protein, alpha-4 chain precursor. [swissprot;acc:p43681]	1	9649.61	1.14549	11053.5
	probable glutamyl-trna(gln) amidotransferase subunit b, mitochondrial precursor (ec 6.3.5.-) (glu-adt subunit b) (cytochrome oxidase assembly factor pet112 homolog). [swissprot;acc:o75879]	0	20612.9	1.0029	20672.6
484	neuronal acetylcholine receptor protein, alpha-3 chain precursor. [swissprot;acc:p32297]	1	9649.61	1.14549	11053.5
	scribble. [refseq;acc:nm_015356]	0	958.429	1.00278	961.098
485	high mobility group protein 4-like (hmg-4l). [swissprot;acc:q9uj13]		22850.1	1.00229	22797.8
	sphingosine kinase 2 (ec 2.7.1.-) (sk 2) (spk 2). [swissprot;acc:q9nra0]	1	9649.61	1.14549	11053.5
486	nuclear autoantigen sp-100 (speckled 100 kda) (nuclear dot-associated sp100 protein) (lysp100b). [swissprot;acc:p23497]	0	22878.7	1.00227	22826.8
	stem cell growth factor; lymphocyte secreted c-type lectin; lymphocyte secreted c-type lectin. [refseq;acc:nm_002975]	1	10908.6	1.14513	12491.8
487	pyrroline 5-carboxylate reductase isoform. [refseq;acc:nm_013328]		5277.4	1.14505	6042.88
	ras-related c3 botulinum toxin substrate 1 (p21-rac1) (ras-like protein tc25). [swissprot;acc:p15154]	0	250.419	1.00225	249.857
488	c-type lectin superfamily member 1 precursor (cartilage-derived c-type lectin). [swissprot;acc:o75596]	1	10872.4	1.14483	12447
	ras-related c3 botulinum toxin substrate 3 (p21-rac3). [swissprot;acc:o14658]	0	250.419	1.00225	249.857
489	dj579f20.1 (high-mobility group (nonhistone chromosomal) protein 1-like 1). [sptrembl;acc:q9nqj4]		22946.3	1.00224	22895.1
	pyrroline-5-carboxylate reductase (ec 1.5.1.2) (p5cr) (p5c reductase). [swissprot;acc:p32322]	1	5281.11	1.14457	6044.61
490	high mobility group protein 1-like 10 (hmg-1l10). [swissprot;acc:q9ugv6]	0	22940.1	1.00224	22888.8
	protein phosphatase 1, regulatory (inhibitor) subunit 13b; apoptosis-stimulating protein of p53, 1. [refseq;acc:nm_015316]	1	15274.9	1.14445	13346.9
491	high mobility group protein 1 (hmg-1). [swissprot;acc:p09429]	0	22962	1.00223	22910.9
	neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]	1	5980.15	1.14437	6843.48
492	3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8]	0	5038.33	1.00159	5046.33
	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	1	5979.94	1.14429	6842.76
493	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]		5979.95		6842.78
	pyruvate dehydrogenase e1 component alpha subunit, testis-specific form, mitochondrial precursor (ec 1.2.4.1) (pdhe1-a type ii). [swissprot;acc:p29803]	0	2410.35	1.00059	2411.78
494	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	1	5979.93	1.14428	6842.72
	histone h2a.c/d/i/n/p (h2a.1) (h2a/c) (h2a/d) (h2a/i) (h2a/n) (h2a/p) (h2a.1b). [swissprot;acc:p02261]	0	0.00001	1	0.00001
495	histone h2a.a (h2a/a) (h2a.2). [swissprot;acc:p28001]
	tetranectin precursor (tn) (plasminogen-kringle 4 binding protein). [swissprot;acc:p05452]	1	10804.7	1.14428	12363.6
496	mitochondrial 28s ribosomal protein s6 (mrp-s6). [swissprot;acc:p82932]	0	0.00001	1	0.00001
	nostrin. [refseq;acc:nm_052946]	1	4682.87	1.1441	4093.05
497	eap30 subunit of ell complex. [refseq;acc:nm_007241]
	histone h2a; h2a histone family, member r. [refseq;acc:nm_170745]	0	0.00001	1	0.00001
498	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	1	4682.87	1.1441	4093.05
	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]	0	0.00001	1	0.00001
499	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]	1	4682.87	1.1441	4093.05
	homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]	0	0.00001	1	0.00001
500	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	1	4682.87	1.1441	4093.05
	rwd domain containing 1; ptd013 protein; cgi-24 protein. [refseq;acc:nm_015952]	0	0.00001	1	0.00001

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.