MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Value Type	Gene	description	Rank	green	network_comparison	red	Filtered	Interaction Map

Results: HTML CSV LaTeX

Showing element 908 to 957 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1
Interaction Map  : High confidence

description	Rank	green	network_comparison	red
egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	200	276.018	1.1372	242.718
eh-domain containing protein 1 (testilin) (hpast1). [swissprot;acc:q9h4m9]	1455	211.085	1.01962	207.024
eh-domain containing protein 2. [swissprot;acc:q9nzn4]	1457	211.086
eh-domain containing protein 3. [swissprot;acc:q9nzn3]	1458
eh-domain containing protein 4 (eh domain-containing protein fksg7) (hepatocellular carcinoma-associated protein 10/11). [swissprot;acc:q9h223]	1456
eif-5a2 protein. [refseq;acc:nm_020390]	2105	210.111	1.00729	208.591
elac homolog 2; putative prostate cancer susceptibility protein; elac (e. coli) homolog 2. [refseq;acc:nm_018127]	1538	232.376	1.01732	228.419
elav-like protein 1 (hu-antigen r) (hur). [swissprot;acc:q15717]	1798	215.242	1.01192	217.807
elav-like protein 2 (hu-antigen b) (hub) (elav-like neuronal protein 1) (nervous system-specific rna binding protein hel-n1). [swissprot;acc:q12926]	1795	215.158	1.01193	217.724
elav-like protein 3 (hu-antigen c) (huc) (paraneoplastic cerebellar degeneration-associated antigen) (paraneoplastic limbic encephalitis antigen 21). [swissprot;acc:q14576]	1791	215.295	1.01194	217.866
elav-like protein 4 (paraneoplastic encephalomyelitis antigen hud) (hu-antigen d). [swissprot;acc:p26378]	1792	215.199	1.01193	217.766
electron transfer flavoprotein alpha-subunit, mitochondrial precursor (alpha-etf). [swissprot;acc:p13804]	2441	180.732	1.0033	180.137
electron transfer flavoprotein beta-subunit (beta-etf). [swissprot;acc:p38117]	2353	183.027	1.00436	182.232
electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (ec 1.5.5.1) (etf-qo) (etf-ubiquinone oxidoreductase) (etf dehydrogenase) (electron-transferring- flavoprotein dehydrogenase). [swissprot;acc:q16134]	2016	197.301	1.00908	199.092
elks protein. [refseq;acc:nm_015064]	1061	211.648	1.03078	218.162
ell-associated factor 2; uncharacterized bone marrow protein bm040; testosterone regulated apoptosis inducer and tumor suppressor. [refseq;acc:nm_018456]	2921	0.00001	1	0.00001
elongation factor 1-alpha 1 (ef-1-alpha-1) (elongation factor 1 a-1) (eef1a-1) (elongation factor tu) (ef-tu). [swissprot;acc:p04720]	2433	218.117	1.00346	217.366
elongation factor 1-alpha 2 (ef-1-alpha-2) (elongation factor 1 a-2) (eef1a-2) (statin s1). [swissprot;acc:q05639]	2436
elongation factor 2 (ef-2). [swissprot;acc:p13639]	2557	223.047	1.00175	222.658
elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897]	3027	0.00001	1	0.00001
elongation of very long chain fatty acids protein 1 (cgi-88). [swissprot;acc:q9bw60]	886	219.018	1.03917	227.596
elongation protein 4 homolog; pax6 neighbor gene; chromosome 11 open reading frame 19. [refseq;acc:nm_019040]	1802	214.481	1.0118	217.011
endo-beta-n-acetylglucosaminidase. [refseq;acc:nm_022759]	1322	156.275	1.02294	159.86
endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]	432	229.411	1.07934	212.547
endosome-associated fyve-domain protein. [refseq;acc:nm_014733]	3200	0.00001	1	0.00001
endothelial-derived gene 1. [refseq;acc:nm_025205]	1918	200.18	1.01015	202.211
enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511]	286	203.251	1.1052	224.633
enhancer of rudimentary homolog. [swissprot;acc:q14259]	2676	215.108	1.001	214.893
enhancer of zeste homolog 1 (enx-2). [swissprot;acc:q92800]	3090	0.00001	1	0.00001
enhancer of zeste homolog 2 (enx-1). [swissprot;acc:q15910]	3098
enigma protein; lim domain protein. [refseq;acc:nm_005451]	1929	217.574	1.01001	219.753
enoyl-coa hydratase, mitochondrial precursor (ec 4.2.1.17) (short chain enoyl-coa hydratase) (sceh) (enoyl-coa hydratase 1). [swissprot;acc:p30084]	1403	180.823	1.0212	184.656
enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]	577	210.944	1.06477	224.606
enthoprotin; epsin 4; clathrin interacting protein localized in the trans-golgi region. [refseq;acc:nm_014666]	1612	224.902	1.0157	221.426
epidermal growth factor receptor kinase substrate eps8. [swissprot;acc:q12929]	1153	216.146	1.02676	221.93
epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [refseq;acc:nm_139204]	1152	216.143	1.02682	221.939
epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [refseq;acc:nm_022772]	1158	216.167	1.02641	221.877
epidermal growth factor receptor precursor (ec 2.7.1.112) (receptor protein-tyrosine kinase erbb-1). [swissprot;acc:p00533]	2005	222.971	1.00919	225.019
epididymal secretory protein e1 precursor (niemann-pick disease type c2 protein) (epi-1) (he1) (epididymal secretory protein 14.6) (esp14.6). [swissprot;acc:q15668]	1339	200.71	1.02239	205.204
epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830]	320	265.96	1.0995	241.892
epoxide hydrolase 1 (ec 3.3.2.3) (microsomal epoxide hydrolase) (epoxide hydratase). [swissprot;acc:p07099]	2446	181.683	1.00324	182.272
epsin 1; eh domain-binding mitotic phosphoprotein. [refseq;acc:nm_013333]	2430	218.644	1.00354	217.873
epsin 2 isoform b; eps15 binding protein. [refseq;acc:nm_014964]	2550	217.988	1.00184	217.587
epsin 3. [refseq;acc:nm_017957]	2297	219.284	1.00518	218.153
ergic-53 protein precursor (er-golgi intermediate compartment 53 kda protein) (lectin, mannose-binding 1) (gp58) (intracellular mannose specific lectin mr60). [swissprot;acc:p49257]	3177	0.00001	1	0.00001
ero1-like. [refseq;acc:nm_014584]	911	209.207	1.03805	217.168
erythroid differentiation and denucleation factor 1. [swissprot;acc:o60584]	1566	224.767	1.01646	221.128
erythroid differentiation-related factor 1. [refseq;acc:nm_015608]	3095	0.00001	1	0.00001
espin. [refseq;acc:nm_031475]	1257	224.7	1.02437	219.354
esterase d (ec 3.1.1.1). [swissprot;acc:p10768]	2429	193.555	1.00355	192.871

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.