MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Value Type	Gene	description	Rank	network_comparison	Filtered	Interaction Map	red	green

Results: HTML CSV LaTeX

Showing element 868 to 917 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1
Interaction Map  : High confidence

description	Rank	network_comparison	red	green
dopachrome tautomerase precursor (ec 5.3.3.12) (dt) (dct) (dopachrome delta-isomerase) (tyrosinase-related protein 2) (trp-2) (trp2). [swissprot;acc:p40126]	1020	1.03205	221.28	214.409
double-strand break repair protein mre11a (mre11 homolog 1). [swissprot;acc:p49959]	1046	1.03121	173.475	178.889
double-stranded rna-binding zinc finger protein jaz. [refseq;acc:nm_012279]	3054	1	0.00001	0.00001
doublecortin (lissencephalin-x) (lis-x) (doublin). [swissprot;acc:o43602]	2725	1.00034	216.496	216.569
doublesex and mab-3 related transcription factor 3; testis-specific protein; dmrt-like family a3. [refseq;acc:nm_021240]	3187	1	0.00001	0.00001
down-regulated in metastasis. [refseq;acc:nm_014503]	787	1.04685	244.447	233.508
dpy-30-like protein. [swissprot;acc:q9c005]	1815	1.01164	220.462	217.926
dr1-associated protein 1; negative cofactor 2 alpha; dr1-associated corepressor. [refseq;acc:nm_006442]	1468	1.01954	212.001	207.937
dual specificity mitogen-activated protein kinase kinase 1 (ec 2.7.1.-) (map kinase kinase 1) (mapkk 1) (erk activator kinase 1) (mapk/erk kinase 1) (mek1). [swissprot;acc:q02750]	2069	1.0081	217.555	215.807
dual specificity mitogen-activated protein kinase kinase 2 (ec 2.7.1.-) (map kinase kinase 2) (mapkk 2) (erk activator kinase 2) (mapk/erk kinase 2) (mek2). [swissprot;acc:p36507]	2072
dual specificity mitogen-activated protein kinase kinase 3 (ec 2.7.1.-) (map kinase kinase 3) (mapkk 3) (mapk/erk kinase 3). [swissprot;acc:p46734]	2385	1.00395	210.595	209.767
dual specificity mitogen-activated protein kinase kinase 4 (ec 2.7.1.-) (map kinase kinase 4) (jnk activating kinase 1) (c-jun n- terminal kinase kinase 1) (jnkk) (sapk/erk kinase 1) (sek1). [swissprot;acc:p45985]	2326	1.00468	220.076	219.05
dual specificity mitogen-activated protein kinase kinase 6 (ec 2.7.1.-) (map kinase kinase 6) (mapkk 6) (mapk/erk kinase 6) (sapkk3). [swissprot;acc:p52564]	2384	1.00397	210.57	209.737
dual specificity mitogen-activated protein kinase kinase 7 (ec 2.7.1.-) (map kinase kinase 7) (mapkk 7) (mapk/erk kinase 7) (jnk activating kinase 2) (c-jun n-terminal kinase kinase 2) (jnk kinase 2) (jnkk 2). [swissprot;acc:o14733]	2139	1.00696	221.248	222.788
dual specificity protein phosphatase 11 (ec 3.1.3.48) (rna/rnp complex-intereracting phosphatase) (phosphatase that interacts with rna/rnp complex 1). [swissprot;acc:o75319]	2926	1	0.00001	0.00001
dual-specificity tyrosine-phosphorylation regulated kinase 1a (ec 2.7.1.-) (protein kinase minibrain homolog) (mnbh) (hp86) (dual specificity yak1-related kinase). [swissprot;acc:q13627]	1800	1.0118	217.011	214.481
dual-specificity tyrosine-phosphorylation regulated kinase 1b (ec 2.7.1.-) (mirk protein kinase). [swissprot;acc:q9y463]	1803
dymeclin. [refseq;acc:nm_017653]	2055	1.00834	218.79	216.981
dynactin 4. [refseq;acc:nm_032486]	426	1.08197	233.142	252.253
dynactin complex 50 kda subunit (50 kda dynein-associated polypeptide) (dynamitin) (dctn-50) (dynactin 2). [swissprot;acc:q13561]	1549	1.01687	225.159	221.424
dynamin 1-like protein isoform 3; dynamin-like protein. [refseq;acc:nm_005690]	2081	1.00787	215.967	214.28
dynein 2 light intermediate chain. [refseq;acc:nm_016008]	2962	1	0.00001	0.00001
dynein intermediate chain 1, axonemal (axonemal dynein intermediate chain 1). [swissprot;acc:q9ui46]	3029
dynein intermediate chain 1, cytosolic (dh ic-1) (cytoplasmic dynein intermediate chain 1). [swissprot;acc:o14576]	1005	1.03307	225.448	218.232
dynein intermediate chain 2, cytosolic (dh ic-2) (cytoplasmic dynein intermediate chain 2). [swissprot;acc:q13409]	998	1.03338	225.557	218.271
dynein light chain 2. [refseq;acc:nm_080677]	647	1.05914	216.731	229.549
dyskerin (nucleolar protein nap57) (cbf5 homolog). [swissprot;acc:o60832]	1085	1.02968	231.007	237.864
dystrobrevin alpha (dystrobrevin-alpha). [swissprot;acc:q9y4j8]	2583	1.00154	213.415	213.743
dystrobrevin beta (beta-dystrobrevin) (dtn-b). [swissprot;acc:o60941]	2581		213.428	213.756
dystrobrevin binding protein 1; dysbindin. [refseq;acc:nm_032122]	1599	1.01617	217.871	214.404
dystrophin. [swissprot;acc:p11532]	2584	1.00154	213.422	213.75
e-1 enzyme. [refseq;acc:nm_021204]	2251	1.00606	208.315	207.061
e1a binding protein p400; p400 swi2/snf2-related protein; cagh32 protein; trinucleotide repeat containing 12. [refseq;acc:nm_015409]	1984	1.00952	219.26	217.193
e1b-55kda-associated protein 5 isoform a. [refseq;acc:nm_007040]	484	1.07405	237.109	254.667
e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	442	1.0783	223.802	207.55
eap30 subunit of ell complex. [refseq;acc:nm_007241]	163	1.19058	209.299	249.187
early endosome antigen 1, 162kd; early endosome-associated protein. [refseq;acc:nm_003566]	1660	1.01434	228.654	231.933
ebp50-pdz interactor of 64 kda (epi64 protein). [swissprot;acc:q9bxi6]	203	1.13516	201.515	228.752
ecotropic viral integration site 5; neuroblastoma stage 4s gene. [refseq;acc:nm_005665]	1437	1.02022	218.829	214.493
ecotropic virus integration 1 site protein. [swissprot;acc:q03112]	3170	1	0.00001	0.00001
egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	200	1.1372	242.718	276.018
eh-domain containing protein 1 (testilin) (hpast1). [swissprot;acc:q9h4m9]	1455	1.01962	207.024	211.085
eh-domain containing protein 2. [swissprot;acc:q9nzn4]	1457			211.086
eh-domain containing protein 3. [swissprot;acc:q9nzn3]	1458
eh-domain containing protein 4 (eh domain-containing protein fksg7) (hepatocellular carcinoma-associated protein 10/11). [swissprot;acc:q9h223]	1456
eif-5a2 protein. [refseq;acc:nm_020390]	2105	1.00729	208.591	210.111
elac homolog 2; putative prostate cancer susceptibility protein; elac (e. coli) homolog 2. [refseq;acc:nm_018127]	1538	1.01732	228.419	232.376
elav-like protein 1 (hu-antigen r) (hur). [swissprot;acc:q15717]	1798	1.01192	217.807	215.242
elav-like protein 2 (hu-antigen b) (hub) (elav-like neuronal protein 1) (nervous system-specific rna binding protein hel-n1). [swissprot;acc:q12926]	1795	1.01193	217.724	215.158
elav-like protein 3 (hu-antigen c) (huc) (paraneoplastic cerebellar degeneration-associated antigen) (paraneoplastic limbic encephalitis antigen 21). [swissprot;acc:q14576]	1791	1.01194	217.866	215.295

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.