MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Value Type	Network Comparison Type	Gene	description	Rank	Filtered	Interaction Map	network_comparison	green	red

Results: HTML CSV LaTeX

Showing element 868 to 917 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1
Interaction Map  : High confidence

description	Rank	network_comparison	green	red
dopachrome tautomerase precursor (ec 5.3.3.12) (dt) (dct) (dopachrome delta-isomerase) (tyrosinase-related protein 2) (trp-2) (trp2). [swissprot;acc:p40126]	1020	1.03205	214.409	221.28
double-strand break repair protein mre11a (mre11 homolog 1). [swissprot;acc:p49959]	1046	1.03121	178.889	173.475
double-stranded rna-binding zinc finger protein jaz. [refseq;acc:nm_012279]	3054	1	0.00001	0.00001
doublecortin (lissencephalin-x) (lis-x) (doublin). [swissprot;acc:o43602]	2725	1.00034	216.569	216.496
doublesex and mab-3 related transcription factor 3; testis-specific protein; dmrt-like family a3. [refseq;acc:nm_021240]	3187	1	0.00001	0.00001
down-regulated in metastasis. [refseq;acc:nm_014503]	787	1.04685	233.508	244.447
dpy-30-like protein. [swissprot;acc:q9c005]	1815	1.01164	217.926	220.462
dr1-associated protein 1; negative cofactor 2 alpha; dr1-associated corepressor. [refseq;acc:nm_006442]	1468	1.01954	207.937	212.001
dual specificity mitogen-activated protein kinase kinase 1 (ec 2.7.1.-) (map kinase kinase 1) (mapkk 1) (erk activator kinase 1) (mapk/erk kinase 1) (mek1). [swissprot;acc:q02750]	2069	1.0081	215.807	217.555
dual specificity mitogen-activated protein kinase kinase 2 (ec 2.7.1.-) (map kinase kinase 2) (mapkk 2) (erk activator kinase 2) (mapk/erk kinase 2) (mek2). [swissprot;acc:p36507]	2072
dual specificity mitogen-activated protein kinase kinase 3 (ec 2.7.1.-) (map kinase kinase 3) (mapkk 3) (mapk/erk kinase 3). [swissprot;acc:p46734]	2385	1.00395	209.767	210.595
dual specificity mitogen-activated protein kinase kinase 4 (ec 2.7.1.-) (map kinase kinase 4) (jnk activating kinase 1) (c-jun n- terminal kinase kinase 1) (jnkk) (sapk/erk kinase 1) (sek1). [swissprot;acc:p45985]	2326	1.00468	219.05	220.076
dual specificity mitogen-activated protein kinase kinase 6 (ec 2.7.1.-) (map kinase kinase 6) (mapkk 6) (mapk/erk kinase 6) (sapkk3). [swissprot;acc:p52564]	2384	1.00397	209.737	210.57
dual specificity mitogen-activated protein kinase kinase 7 (ec 2.7.1.-) (map kinase kinase 7) (mapkk 7) (mapk/erk kinase 7) (jnk activating kinase 2) (c-jun n-terminal kinase kinase 2) (jnk kinase 2) (jnkk 2). [swissprot;acc:o14733]	2139	1.00696	222.788	221.248
dual specificity protein phosphatase 11 (ec 3.1.3.48) (rna/rnp complex-intereracting phosphatase) (phosphatase that interacts with rna/rnp complex 1). [swissprot;acc:o75319]	2926	1	0.00001	0.00001
dual-specificity tyrosine-phosphorylation regulated kinase 1a (ec 2.7.1.-) (protein kinase minibrain homolog) (mnbh) (hp86) (dual specificity yak1-related kinase). [swissprot;acc:q13627]	1800	1.0118	214.481	217.011
dual-specificity tyrosine-phosphorylation regulated kinase 1b (ec 2.7.1.-) (mirk protein kinase). [swissprot;acc:q9y463]	1803
dymeclin. [refseq;acc:nm_017653]	2055	1.00834	216.981	218.79
dynactin 4. [refseq;acc:nm_032486]	426	1.08197	252.253	233.142
dynactin complex 50 kda subunit (50 kda dynein-associated polypeptide) (dynamitin) (dctn-50) (dynactin 2). [swissprot;acc:q13561]	1549	1.01687	221.424	225.159
dynamin 1-like protein isoform 3; dynamin-like protein. [refseq;acc:nm_005690]	2081	1.00787	214.28	215.967
dynein 2 light intermediate chain. [refseq;acc:nm_016008]	2962	1	0.00001	0.00001
dynein intermediate chain 1, axonemal (axonemal dynein intermediate chain 1). [swissprot;acc:q9ui46]	3029
dynein intermediate chain 1, cytosolic (dh ic-1) (cytoplasmic dynein intermediate chain 1). [swissprot;acc:o14576]	1005	1.03307	218.232	225.448
dynein intermediate chain 2, cytosolic (dh ic-2) (cytoplasmic dynein intermediate chain 2). [swissprot;acc:q13409]	998	1.03338	218.271	225.557
dynein light chain 2. [refseq;acc:nm_080677]	647	1.05914	229.549	216.731
dyskerin (nucleolar protein nap57) (cbf5 homolog). [swissprot;acc:o60832]	1085	1.02968	237.864	231.007
dystrobrevin alpha (dystrobrevin-alpha). [swissprot;acc:q9y4j8]	2583	1.00154	213.743	213.415
dystrobrevin beta (beta-dystrobrevin) (dtn-b). [swissprot;acc:o60941]	2581		213.756	213.428
dystrobrevin binding protein 1; dysbindin. [refseq;acc:nm_032122]	1599	1.01617	214.404	217.871
dystrophin. [swissprot;acc:p11532]	2584	1.00154	213.75	213.422
e-1 enzyme. [refseq;acc:nm_021204]	2251	1.00606	207.061	208.315
e1a binding protein p400; p400 swi2/snf2-related protein; cagh32 protein; trinucleotide repeat containing 12. [refseq;acc:nm_015409]	1984	1.00952	217.193	219.26
e1b-55kda-associated protein 5 isoform a. [refseq;acc:nm_007040]	484	1.07405	254.667	237.109
e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	442	1.0783	207.55	223.802
eap30 subunit of ell complex. [refseq;acc:nm_007241]	163	1.19058	249.187	209.299
early endosome antigen 1, 162kd; early endosome-associated protein. [refseq;acc:nm_003566]	1660	1.01434	231.933	228.654
ebp50-pdz interactor of 64 kda (epi64 protein). [swissprot;acc:q9bxi6]	203	1.13516	228.752	201.515
ecotropic viral integration site 5; neuroblastoma stage 4s gene. [refseq;acc:nm_005665]	1437	1.02022	214.493	218.829
ecotropic virus integration 1 site protein. [swissprot;acc:q03112]	3170	1	0.00001	0.00001
egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	200	1.1372	276.018	242.718
eh-domain containing protein 1 (testilin) (hpast1). [swissprot;acc:q9h4m9]	1455	1.01962	211.085	207.024
eh-domain containing protein 2. [swissprot;acc:q9nzn4]	1457		211.086
eh-domain containing protein 3. [swissprot;acc:q9nzn3]	1458
eh-domain containing protein 4 (eh domain-containing protein fksg7) (hepatocellular carcinoma-associated protein 10/11). [swissprot;acc:q9h223]	1456
eif-5a2 protein. [refseq;acc:nm_020390]	2105	1.00729	210.111	208.591
elac homolog 2; putative prostate cancer susceptibility protein; elac (e. coli) homolog 2. [refseq;acc:nm_018127]	1538	1.01732	232.376	228.419
elav-like protein 1 (hu-antigen r) (hur). [swissprot;acc:q15717]	1798	1.01192	215.242	217.807
elav-like protein 2 (hu-antigen b) (hub) (elav-like neuronal protein 1) (nervous system-specific rna binding protein hel-n1). [swissprot;acc:q12926]	1795	1.01193	215.158	217.724
elav-like protein 3 (hu-antigen c) (huc) (paraneoplastic cerebellar degeneration-associated antigen) (paraneoplastic limbic encephalitis antigen 21). [swissprot;acc:q14576]	1791	1.01194	215.295	217.866

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.