MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	description	Network Comparison Type	Value Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 851 to 900 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	green	red	network_comparison
426	dynactin 4. [refseq;acc:nm_032486]	Divided	252.253	233.142	1.08197
	programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831]	Subtracted	229.411	212.547	16.864
427	dna-directed rna polymerase ii 23 kda polypeptide (ec 2.7.7.6) (rpb25) (xap4) (rpb5) (rpabc1). [swissprot;acc:p19388]	Divided	259.525	239.977	1.08146
	t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	Subtracted	229.411	212.547	16.864
428	atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072]	Divided	234.808	253.852	1.0811
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	Subtracted	210.888	227.748	16.86
429	polymerase (rna) iii (dna directed) (32kd). [refseq;acc:nm_006467]	Divided	259.038	239.709	1.08064
	probable rrna processing protein ebp2 (ebna1 binding protein 2) (nucleolar protein p40). [swissprot;acc:q99848]	Subtracted	234.514	251.344	16.83
430	suppressor of swi4 1 homolog (ssf-1) (peter pan homolog). [swissprot;acc:q9nq55]		234.134	250.938	16.804
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	Divided	210.888	227.748	1.07995
431	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]	Subtracted	216.737	233.529	16.792
	trub pseudouridine (psi) synthase homolog 1. [refseq;acc:nm_139169]	Divided	255.113	236.245	1.07987
432	endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]		229.411	212.547	1.07934
	mct-1 protein. [refseq;acc:nm_014060]	Subtracted	243.03	226.313	16.717
433	mitochondrial ribosomal protein l22. [refseq;acc:nm_014180]
	programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831]	Divided	229.411	212.547	1.07934
434	ad24 protein. [refseq;acc:nm_022451]	Subtracted	234.672	251.334	16.662
	t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	Divided	229.411	212.547	1.07934
435	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]		205.286	221.522	1.07909
	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	Subtracted	234.729	251.299	16.57
436	paxillin. [swissprot;acc:p49023]	Divided	205.286	221.522	1.07909
	triosephosphate isomerase (ec 5.3.1.1) (tim). [swissprot;acc:p00938]	Subtracted	248.048	231.496	16.552
437	cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642]	Divided	226.459	209.921	1.07878
		Subtracted			16.538
438	block of proliferation 1. [swissprot;acc:q14137]		234.433	250.794	16.361
	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]	Divided	216.674	233.723	1.07869
439	40s ribosomal protein s9. [swissprot;acc:p46781]		257.784	238.986	1.07866
	pescadillo homolog 1. [swissprot;acc:o00541]	Subtracted	234.941	251.297	16.356
440	40s ribosomal protein s26. [swissprot;acc:p02383]		226.578	210.224	16.354
	highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	Divided	249.983	231.802	1.07843
441	grb2-related adaptor protein. [swissprot;acc:q13588]		207.222	223.457	1.07835
	mitochondrial import inner membrane translocase subunit tim22. [swissprot;acc:q9y584]	Subtracted	226.578	210.225	16.353
442	atp synthase mitochondrial f1 complex assembly factor 2. [refseq;acc:nm_145691]
	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	Divided	207.55	223.802	1.0783
443	neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]		207.539	223.79
	ubiquinol-cytochrome c reductase complex 14 kda protein (ec 1.10.2.2) (complex iii subunit vi) (qp-c). [swissprot;acc:p14927]	Subtracted	226.578	210.225	16.353
444	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	Divided	207.549	223.801	1.0783
	proliferating-cell nucleolar antigen p120 (proliferation-associated nucleolar protein p120). [swissprot;acc:p46087]	Subtracted	233.725	250.053	16.328
445	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]	Divided	207.549	223.801	1.0783
	nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	Subtracted	234.563	250.858	16.295
446	growth factor receptor-bound protein 2 (grb2 adapter protein) (sh2/sh3 adapter grb2) (ash protein). [swissprot;acc:p29354]	Divided	207.785	224.049	1.07827
		Subtracted			16.264
447	serine/threonine-protein kinase nek2 (ec 2.7.1.37) (nima-related protein kinase 2) (nima-like protein kinase 1) (hspk 21). [swissprot;acc:p51955]	Divided			1.07827
		Subtracted			16.264
448	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]		207.55	223.802	16.252
	microtubule-actin crosslinking factor 1, isoform 4. [swissprot;acc:q96pk2]	Divided	246.338	228.468	1.07822
449	bullous pemphigoid antigen 1 isoforms 1/2/3/4/5/8 (230 kda bullous pemphigoid antigen) (bpa) (hemidesmosomal plaque protein) (dystonia musculorum protein) (fragment). [swissprot;acc:q03001]		246.33	228.463	1.07821
	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	Subtracted	207.549	223.801	16.252
450	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Divided	218.837	235.94	1.07815

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.