Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene Value Type green Network Comparison Type Rank Interaction Map description red network_comparison Filtered

Results: HTML CSV LaTeX

Showing element 8241 to 8290 of 77072 in total

Value Type

: Measured
Filtered

: 1

green	Network Comparison Type	Rank	Interaction Map	description	red	network_comparison
7186.45	Divided	1167	High confidence	sodium-dependent multivitamin transporter (na(+)-dependent multivitamin transporter). [swissprot;acc:q9y289]	6607.68	1.08759
7186.45	Subtracted	873			6607.68	578.77
7190.91	Divided	448		ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	6259.3	1.14884
7190.91	Subtracted	403			6259.3	931.61
7191.88	Divided	2498		helicase (fragment). [sptrembl;acc:q92771]	7002.03	1.02711
7191.88	Subtracted	2400		helicase (fragment). [sptrembl;acc:q92771]	7002.03	189.85
7192.08	Divided	440		calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]	6251.91	1.15038
7192.08	Subtracted	392			6251.91	940.17
7192.13	Divided	441		grancalcin. [swissprot;acc:p28676]	6251.96	1.15038
7192.13	Subtracted	393		grancalcin. [swissprot;acc:p28676]	6251.96	940.17
7192.17	Divided	442		sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	6251.99	1.15038
7192.17	Subtracted	391			6251.99	940.18
7192.25	Divided	2497		dead/h (asp-glu-ala-asp/his) box polypeptide 11; dead/h box-11 (chl1-related helicase gene-1); yeast chl1 homolog. [refseq;acc:nm_030655]	7002.3	1.02713
7192.25	Subtracted	2399			7002.3	189.95
7192.51	Divided	443		brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]	6252.27	1.15038
7192.51	Subtracted	390			6252.27	940.24
7192.88	Divided	438		swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]	6252.58	1.15039
	Divided	439		programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]		1.15039
	Subtracted	388		swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]		940.3
	Subtracted	389		programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]		940.3
7194.65	Divided	2571		kruppel-related zinc finger protein hckrox. [refseq;acc:nm_015872]	7056.13	1.01963
7194.65	Subtracted	2510			7056.13	138.52
7194.87	Divided	2572		zinc finger protein 288 (dendritic-derived btb/poz zinc finger protein). [swissprot;acc:q9hc78]	7056.42	1.01962
7194.87	Subtracted	2511			7056.42	138.45
7194.99	Divided	2573		peroxisomal targeting signal 2 receptor (pts2 receptor) (peroxin-7). [swissprot;acc:o00628]	7056.58	1.01961
7194.99	Subtracted	2512			7056.58	138.41
7195.59	Divided	358	Low confidence	calpain 1, large [catalytic] subunit (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (mu-type) (mucanp) (micromolar-calpain). [swissprot;acc:p07384]	6822.26	1.05472
7195.59	Subtracted	559			6822.26	373.33
7196.02	Divided	357		calpain 2, large [catalytic] subunit precursor (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain) (calpain large polypeptide l2). [swissprot;acc:p17655]	6822.68	1.05472
7196.02	Subtracted	558			6822.68	373.34
7202.96	Divided	4525		dj153g14.2 (possible ca binding protein similar to nefa) (fragment). [sptrembl;acc:q9ujn8]	7074.54	1.01815
7202.96	Subtracted	4642			7074.54	128.42
7204.94	Divided	3714		associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	7382.5	1.02464
7204.94	Subtracted	4160			7382.5	177.56
7206.52	Divided	4520		retinoblastoma-binding protein 1 (rbbp-1). [swissprot;acc:p29374]	7077.6	1.01822
7206.52	Subtracted	4636				128.92
7206.53	Divided	4521		peripheral benzodiazepine receptor-associated protein 1. [refseq;acc:nm_004758]		1.01822
7206.53	Subtracted	4635				128.93
7208.38	Divided	3740		px serine/threonine kinase. [refseq;acc:nm_017771]	7384.52	1.02444
	Divided	3741		bromodomain adjacent to zinc finger domain protein 1a (atp-utilizing chromatin assembly and remodeling factor 1) (hacf1) (atp-dependent chromatin remodelling protein) (williams syndrome transcription factor-related chromatin remodeling factor 180) (wcrf180) (hwalp1) (chrac subunit acf1) (hspc317). [swissprot;acc:q9nrl2]		1.02444
	Subtracted	4172		px serine/threonine kinase. [refseq;acc:nm_017771]		176.14
	Subtracted	4173		bromodomain adjacent to zinc finger domain protein 1a (atp-utilizing chromatin assembly and remodeling factor 1) (hacf1) (atp-dependent chromatin remodelling protein) (williams syndrome transcription factor-related chromatin remodeling factor 180) (wcrf180) (hwalp1) (chrac subunit acf1) (hspc317). [swissprot;acc:q9nrl2]		176.14
7208.46	Divided	3742		testis specific, 10. [refseq;acc:nm_025244]	7384.57	1.02443
7208.46	Subtracted	4174		testis specific, 10. [refseq;acc:nm_025244]	7384.57	176.11
7209.36	Divided	4514		multiple coagulation factor deficiency 2; neural stem cell derived neuronal survival protein; multiple coagulation factor deficiency protein 2. [refseq;acc:nm_139279]	7080.03	1.01827
7209.36	Subtracted	4628			7080.03	129.33
7211.2	Divided	3766		associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	7386.18	1.02427
7211.2	Subtracted	4187			7386.18	174.98
7213.41	Divided	4538		protein c20orf43 (hspc164/hspc169) (ad-007) (cda05). [swissprot;acc:q9by42]	7342.16	1.01785
7213.41	Subtracted	4639			7342.16	128.75

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/