MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

red	Network Comparison Type	Gene	Value Type	Rank	description	green	Interaction Map	Filtered	network_comparison

Results: HTML CSV LaTeX

Showing element 8241 to 8290 of 29840 in total

Value Type  : Rooted
Interaction Map  : High confidence
Filtered  : 1

red	Network Comparison Type	Rank	description	green	network_comparison
62.4421	Divided	2530	integrin-linked protein kinase 1 (ec 2.7.1.-) (ilk-1) (59 kda serine/threonine protein kinase) (p59ilk). [swissprot;acc:q13418]	63.0512	1.00975
		2531	ras suppressor protein 1 (rsu-1) (rsp-1). [swissprot;acc:q15404]
		2532	ras-gtpase-activating protein binding protein 2 (gap sh3-domain binding protein 2) (g3bp-2). [swissprot;acc:q9un86]
		2533	espin. [refseq;acc:nm_031475]
		2534	cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [swissprot;acc:p10635]
		2535	pleckstrin homology domain containing, family c (with ferm domain) member 1; mitogen inducible 2; kindlin 2. [refseq;acc:nm_006832]
		2536	lim and senescent cell antigen-like domains 2; ilk-binding protein. [refseq;acc:nm_017980]
		2537	d(4) dopamine receptor (d(2c) dopamine receptor). [swissprot;acc:p21917]
	Subtracted	2528	keratin associated protein 4.3 (fragment). [sptrembl;acc:q9byr4]	63.0515	0.6094
		2529	keratin associated protein 2-4; keratin associated protein 2.4. [refseq;acc:nm_033184]
		2530	keratin associated protein 1.5. [refseq;acc:nm_031957]
		2531	keratin, ultra high-sulfur matrix protein b (uhs keratin b) (uhs kerb). [swissprot;acc:o75690]
		2532	keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371]
		2533	keratin associated protein 1-3; keratin associated protein 1.3. [refseq;acc:nm_030966]
		2534	keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060]	63.0514	0.6093
		2535	keratin associated protein 4-2; keratin associated protein 4.2. [refseq;acc:nm_033062]
		2536	keratin associated protein 4.4. [refseq;acc:nm_032524]
		2537	keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]	63.0513	0.6092
		2538	keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]
		2539	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]
		2540	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]
		2541	star-related lipid transfer protein 4 (stard4) (start domain- containing protein 4). [swissprot;acc:q96dr4]
		2542	ras-gtpase-activating protein binding protein 1 (gap sh3-domain binding protein 1) (g3bp-1). [swissprot;acc:q13283]
		2543	star-related lipid transfer protein 5 (stard5) (start domain- containing protein 5). [swissprot;acc:q9nsy2]	63.0512	0.6091
		2544	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]
		2545	pinch protein (particularly interesting new cys-his protein) (lim and senescent cell antigen-like domains 1). [swissprot;acc:p48059]
		2546	integrin-linked protein kinase 1 (ec 2.7.1.-) (ilk-1) (59 kda serine/threonine protein kinase) (p59ilk). [swissprot;acc:q13418]
		2547	ras suppressor protein 1 (rsu-1) (rsp-1). [swissprot;acc:q15404]
		2548	ras-gtpase-activating protein binding protein 2 (gap sh3-domain binding protein 2) (g3bp-2). [swissprot;acc:q9un86]
		2549	espin. [refseq;acc:nm_031475]
		2550	cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [swissprot;acc:p10635]
		2551	pleckstrin homology domain containing, family c (with ferm domain) member 1; mitogen inducible 2; kindlin 2. [refseq;acc:nm_006832]
		2552	lim and senescent cell antigen-like domains 2; ilk-binding protein. [refseq;acc:nm_017980]
		2553	d(4) dopamine receptor (d(2c) dopamine receptor). [swissprot;acc:p21917]
62.4423	Divided	2510	keratin associated protein 9.2. [refseq;acc:nm_031961]	63.0566	1.00984
	Subtracted	2522			0.6143
62.4582	Divided	986	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]	65.9096	1.05526
		987	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase ac39 subunit) (v-atpase 40 kda accessory protein) (p39) (32 kda accessory protein). [swissprot;acc:p12953]
		988	adp-ribosylation factor-like protein 4. [swissprot;acc:p40617]
	Subtracted	985	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]		3.4514
		986	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase ac39 subunit) (v-atpase 40 kda accessory protein) (p39) (32 kda accessory protein). [swissprot;acc:p12953]
		987	adp-ribosylation factor-like protein 4. [swissprot;acc:p40617]
62.4888	Divided	1518	nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8]	64.793	1.03687
	Subtracted	1562			2.3042
62.4892	Divided	2675	arf gtpase-activating protein git1 (g protein-coupled receptor kinase- interactor 1). [swissprot;acc:q9y2x7]	62.7542	1.00424
	Subtracted				0.265
62.5007	Divided	791	cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642]	58.6648	1.06539
	Subtracted	866			3.8359
62.5036	Divided	1297	proteasome subunit beta type 4 precursor (ec 3.4.25.1) (proteasome beta chain) (macropain beta chain) (multicatalytic endopeptidase complex beta chain) (proteasome chain 3) (hsn3) (hsbpros26). [swissprot;acc:p28070]	65.2268	1.04357
	Subtracted	1277			2.7232

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.