MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Rank	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 808 to 857 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	network_comparison	green
404	dna repair protein rad52 homolog. [swissprot;acc:p43351]	Divided	207.908	1.08807	226.218
405	clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]		207.931	1.0879	226.209
	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	Subtracted	65.4586	17.5875	83.0461
406	neuropilin- and tolloid-like protein 2 precursor. [refseq;acc:nm_018092]		237.109	17.558	254.667
	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]	Divided	265.634	1.08731	244.304
407	28s ribosomal protein s9, mitochondrial precursor (mrp-s9). [swissprot;acc:p82933]		239.75	1.08673	260.544
	neuropilin- and tolloid-like protein 1 isoform 3 precursor. [refseq;acc:nm_138966]	Subtracted	237.109	17.558	254.667
408	ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]	Divided	255.112	1.08649	234.804
	heterogenous nuclear ribonucleoprotein u (hnrnp u) (scaffold attachment factor a) (saf-a). [swissprot;acc:q00839]	Subtracted	237.109	17.558	254.667
409	rna polymerase i associated factor 53. [refseq;acc:nm_022490]	Divided	241.045	1.08641	261.874
	runt-related transcription factor 2 (core-binding factor, alpha 1 subunit) (cbf-alpha 1) (acute myeloid leukemia 3 protein) (oncogene aml-3) (polyomavirus enhancer binding protein 2 alpha a subunit) (pebp2-alpha a) (pea2-alpha a) (sl3-3 enhancer factor 1 alpha a subunit) (sl3/akv core-binding factor alpha a subunit) (osteoblast- specific transcription factor 2) (osf-2). [swissprot;acc:q13950]	Subtracted	237.109	17.558	254.667
410	e1b-55kda-associated protein 5 isoform a. [refseq;acc:nm_007040]
	tfiih basal transcription factor complex p44 subunit (basic transcription factor 2 44 kda subunit) (btf2-p44) (general transcription factor iih polypeptide 2). [swissprot;acc:q13888]	Divided	233.376	1.0864	253.539
411	60s ribosomal protein l18. [swissprot;acc:q07020]	Subtracted	237.109	17.558	254.667
	tfiih basal transcription factor complex p62 subunit (basic transcription factor 62 kda subunit) (btf2-p62) (general transcription factor iih polypeptide 1). [swissprot;acc:p32780]	Divided	233.376	1.0864	253.539
412	saccharomyces cerevisiae nip7p homolog. [refseq;acc:nm_016101]	Subtracted	251.926	17.379	234.547
	ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial precursor (ec 1.10.2.2) (rieske iron-sulfur protein) (risp). [swissprot;acc:p47985]	Divided	240.788	1.08567	261.416
413	dna-directed rna polymerase i 40 kda polypeptide (ec 2.7.7.6) (rpa40) (rpa39). [swissprot;acc:o15160]		240.913	1.08525	261.45
	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	Subtracted	223.202	17.302	205.9
414	katanin p60 subunit a 1. [refseq;acc:nm_007044]	Divided	232.431	1.08522	252.238
	max protein. [swissprot;acc:p25912]	Subtracted	227.828	17.267	210.561
415	katanin p80 subunit b 1; katanin (80 kda); katanin p80 (wd40-containing) subunit b 1. [refseq;acc:nm_005886]	Divided	232.382	1.08514	252.166
	transcription initiation factor tfiid 55 kda subunit (tafii-55) (tafii55). [swissprot;acc:q15545]	Subtracted	200.586	17.163	183.423
416	dna-directed rna polymerase i 135 kda polypeptide (ec 2.7.7.6) (rna polymerase i subunit 2) (rpa135). [swissprot;acc:q9h9y6]	Divided	240.6	1.08496	261.041
	tata box binding protein-associated factor, rna polymerase ii, q; taf7-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 50 kd; tbp-associated factor, rna polymerase ii, q. [refseq;acc:nm_024885]	Subtracted	200.791	17.131	183.66
417	set domain and mariner transposase fusion gene. [refseq;acc:nm_006515]	Divided	233.539	1.08417	253.197
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Subtracted	235.94	17.103	218.837
418	cd209 antigen-like; putative type ii membrane protein. [refseq;acc:nm_014257]	Divided	233.539	1.08417	253.197
	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]	Subtracted	233.723	17.049	216.674
419	low affinity immunoglobulin epsilon fc receptor (lymphocyte ige receptor) (fc-epsilon-rii) (cd23) (blast-2) (immunoglobulin e-binding factor). [swissprot;acc:p06734]	Divided	233.539	1.08417	253.197
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Subtracted	235.922	16.997	218.925
420	cd209 antigen; dendritic cell-specific icam3-grabbing nonintegrin. [refseq;acc:nm_021155]	Divided	233.539	1.08417	253.197
	cytochrome c1, heme protein, mitochondrial precursor (cytochrome c-1). [swissprot;acc:p08574]	Subtracted	238.704	16.976	255.68
421	oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1]
	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	Divided	223.202	1.08403	205.9
422	ras-related protein rab-37. [swissprot;acc:q96ax2]		240.287	1.08284	260.193
	senescence marker protein-30 (smp-30) (regucalcin) (rc). [swissprot;acc:q15493]	Subtracted	238.704	16.976	255.68
423	oligophrenin 1. [swissprot;acc:o60890]
	ras-related protein rab-26. [swissprot;acc:q9ulw5]	Divided	240.287	1.08284	260.193
424	dna-directed rna polymerase ii 33 kda polypeptide (ec 2.7.7.6) (rpb3) (rna polymerase ii subunit 3) (rpb33) (rpb31). [swissprot;acc:p19387]
	nucleolar gtp-binding protein 1 (chronic renal failure gene protein) (gtp-binding protein ngb). [swissprot;acc:q9bze4]	Subtracted	251.83	16.879	234.951
425	endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]		212.547	16.864	229.411
	max protein. [swissprot;acc:p25912]	Divided	227.828	1.082	210.561
426	dynactin 4. [refseq;acc:nm_032486]		233.142	1.08197	252.253
	programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831]	Subtracted	212.547	16.864	229.411
427	dna-directed rna polymerase ii 23 kda polypeptide (ec 2.7.7.6) (rpb25) (xap4) (rpb5) (rpabc1). [swissprot;acc:p19388]	Divided	239.977	1.08146	259.525
	t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	Subtracted	212.547	16.864	229.411
428	atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072]	Divided	253.852	1.0811	234.808
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	Subtracted	227.748	16.86	210.888
429	polymerase (rna) iii (dna directed) (32kd). [refseq;acc:nm_006467]	Divided	239.709	1.08064	259.038

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.