MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Value Type	Gene	Rank	network_comparison	Interaction Map	red	description	green	Filtered

Results: HTML CSV LaTeX

Showing element 80 to 129 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	network_comparison	red	description	green
80	1.43834	4133.47	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	5945.32
81	1.43691	4136.36	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	5943.56
82	1.42694	4172.91	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	5954.48
83	1.42597	4932.27	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	7033.29
84			jun dimerization protein. [refseq;acc:nm_130469]
85	1.42395	4941.95	fos-related antigen 2. [swissprot;acc:p15408]	7037.11
86	1.42384	4942.49	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	7037.32
87	1.42347	4944.3	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	7038.04
88	1.42259	2411.93	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	1695.45
89	1.4217	2414.22	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]	1698.12
90	1.4215	2414.77	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	1698.75
91	1.42082	2416.53	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	1700.8
92	1.40882	4117.67	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	5801.04
93	1.39977	4245.52	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	5942.75
94	1.39879	4247.86	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	5941.88
95	1.39481	2397.19	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	3343.62
96	1.3856	4110.14	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	5694.99
97	1.3817	2820.51	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	3897.1
98	1.3705	2353.63	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	3225.65
99			s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]
100			f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]
101			cullin homolog 2 (cul-2). [swissprot;acc:q13617]
102			presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]
103			cullin homolog 1 (cul-1). [swissprot;acc:q13616]
104	1.36996	4241.57	musashi 2 isoform a. [refseq;acc:nm_138962]	5810.79
105			musashi 1. [refseq;acc:nm_002442]
106			nuclear protein ukp68. [refseq;acc:nm_024824]
107	1.36977	4266.04	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	5843.51
108	1.35116	4366.44	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	5899.76
109			rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]
110			protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]
111			protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]
112			u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]
113			filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]
114	1.35048	4300.47	huntingtin interacting protein c. [refseq;acc:nm_012272]	5807.72
115	1.34491	21185	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	28492
116			pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]
117			pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]
118			pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]
119			mitochondrial solute carrier protein. [refseq;acc:nm_145305]
120	1.34247	5136.78	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	6895.98
121	1.3422	5579.18	transcription factor jun-b. [swissprot;acc:p17275]	7488.4
122	1.34112	5140.14	high-mobility group 20a. [refseq;acc:nm_018200]	6893.53
123	1.33503	24260.3	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	18172.1
124	1.33501	24255.7	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	18168.9
125			microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]
126	1.33499	24250	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	18164.9
127	1.33436	5638.2	transcription factor jun-d. [swissprot;acc:p17535]	7523.39
128	1.3341	4355.61	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	5810.82
129	1.33348	4358.13	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	5811.49

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.