Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 777 to 826 of 3228 in total
Value Type: Ranked
Network Comparison Type: Divided
Interaction Map: High confidence
Filtered: 1
\def\wcA{0.16666666666667\textwidth} \def\wcB{0.16666666666667\textwidth} \def\wcC{0.16666666666667\textwidth} \def\wcD{0.16666666666667\textwidth} \def\wcE{0.16666666666667\textwidth} \begin{longtable}{|c|c|c|c|c|} \hline \parbox{\wcA}{\vspace{3pt}\noindent Rank\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent description\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent red\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent green\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent network\_comparison\vspace{3pt}}\\ \hline \hline \parbox{\wcA}{\vspace{3pt}\noindent 777\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent histone deacetylase 1 (hd1). [source:swissprot;acc:q13547]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 225.989\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 215.53\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.04853\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 778\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent sorting nexin 6 (traf4-associated factor 2). [source:swissprot;acc:q9unh7]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 209.191\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 219.332\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.04848\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 779\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent deoxycytidylate deaminase (ec 3.5.4.12) (dcmp deaminase). [source:swissprot;acc:p32321]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 230.516\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 241.641\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.04826\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 780\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent dna-directed rna polymerase ii 14.4 kda polypeptide (ec 2.7.7.6) (rpb6) (rpb14.4) (rpabc2). [source:swissprot;acc:p41584]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 232.762\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 243.933\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.04799\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 781\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent ribosomal protein p0-like protein; 60s acidic ribosomal protein po; ribosomal protein, large, p0-like. [source:refseq;acc:nm\_016183]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 245.84\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 257.636\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.04798\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 782\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent translin. [source:swissprot;acc:q15631]\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent 224.385\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcD}{\vspace{3pt}\noindent 235.131\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcE}{\vspace{3pt}\noindent 1.04789\vspace{3pt}}}\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 783\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent translin-associated protein x (translin-associated factor x). [source:swissprot;acc:q99598]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 784\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [source:refseq;acc:nm\_005710]\vspace{3pt}}&&&\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 785\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent neuroepithelial cell transforming gene 1; guanine nucleotide regulatory protein (oncogene); rho guanine nucleotide exchange factor (gef) 8. [source:refseq;acc:nm\_005863]\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent 244.447\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcD}{\vspace{3pt}\noindent 233.508\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcE}{\vspace{3pt}\noindent 1.04685\vspace{3pt}}}\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 786\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent rho guanine nucleotide exchange factor 3; rhogef protein; 59.8 kda protein; exchange factor found in platelets and leukemic and neuronal tissues, xpln. [source:refseq;acc:nm\_019555]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 787\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent down-regulated in metastasis. [source:refseq;acc:nm\_014503]\vspace{3pt}}&&&\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 788\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent hira-interacting protein 5 (cgi-33). [source:swissprot;acc:q9ums0]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 138.705\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 132.538\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.04653\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 789\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent 40s ribosomal protein sa (p40) (34/67 kda laminin receptor) (colon carcinoma laminin-binding protein) (nem/1chd4) (multidrug resistance- associated protein mgr1-ag). [source:swissprot;acc:p08865]\vspace{3pt}}&\multirow{10}{*}{\parbox{\wcC}{\vspace{3pt}\noindent 224.244\vspace{3pt}}}&\multirow{10}{*}{\parbox{\wcD}{\vspace{3pt}\noindent 234.511\vspace{3pt}}}&\multirow{10}{*}{\parbox{\wcE}{\vspace{3pt}\noindent 1.04578\vspace{3pt}}}\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 790\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent 40s ribosomal protein s21. [source:swissprot;acc:p35265]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 791\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent cytoplasmic antiproteinase 3 (cap3) (cap-3) (protease inhibitor 9) (serpin b9). [source:swissprot;acc:p50453]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 792\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent maspin precursor (protease inhibitor 5). [source:swissprot;acc:p36952]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 793\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent bomapin (protease inhibitor 10) (serpin b10). [source:swissprot;acc:p48595]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 794\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent plasminogen activator inhibitor-2 precursor (pai-2) (placental plasminogen activator inhibitor) (monocyte arg-serpin) (urokinase inhibitor). [source:swissprot;acc:p05120]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 795\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent serpin b11. [source:swissprot;acc:q96p15]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 796\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent placental thrombin inhibitor (cytoplasmic antiproteinase) (cap) (protease inhibitor 6) (pi-6). [source:swissprot;acc:p35237]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 797\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [source:swissprot;acc:p50452]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 798\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent leukocyte elastase inhibitor (lei) (monocyte/neutrophil elastase inhibitor) (m/nei) (ei). [source:swissprot;acc:p30740]\vspace{3pt}}&&&\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 799\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent sequestosome 1; ubiquitin-binding protein p62; phosphotyrosine independent ligand for the lck sh2 domain p62. [source:refseq;acc:nm\_003900]\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent 221.965\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent 212.404\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent 1.04501\vspace{3pt}}}\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 800\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent nonspecific lipid-transfer protein, mitochondrial precursor (nsl-tp) (sterol carrier protein 2) (scp-2) (sterol carrier protein x) (scp-x) (scpx). [source:swissprot;acc:p22307]\vspace{3pt}}&&&\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 801\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent beta-catenin (pro2286). [source:swissprot;acc:p35222]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 224.445\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 214.894\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.04445\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 802\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent testis-specific protein tex28. [source:swissprot;acc:o15482]\vspace{3pt}}&\multirow{16}{*}{\parbox{\wcC}{\vspace{3pt}\noindent 212.386\vspace{3pt}}}&\multirow{16}{*}{\parbox{\wcD}{\vspace{3pt}\noindent 221.785\vspace{3pt}}}&\multirow{16}{*}{\parbox{\wcE}{\vspace{3pt}\noindent 1.04425\vspace{3pt}}}\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 803\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent similar to nuclear protein e3-3 orf1. [source:sptrembl;acc:q9bu61]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 804\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent a kindred of iglon. [source:refseq;acc:nm\_173808]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 805\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent ankyrin-repeat family a protein 2 (rfxank-like 2). [source:swissprot;acc:q9h9e1]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 806\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent inflammation-related g protein-coupled receptor ex33. [source:refseq;acc:nm\_020370]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 807\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [source:swissprot;acc:p50897]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 808\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [source:swissprot;acc:q9h115]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 809\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent syntaxin 16 (syn16). [source:swissprot;acc:o14662]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 810\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent 27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [source:swissprot;acc:o14653]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 811\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent syntaxin 1a (neuron-specific antigen hpc-1). [source:swissprot;acc:q16623]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 812\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [source:swissprot;acc:p54920]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 813\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent adipocyte plasma membrane-associated protein (bscv protein). [source:swissprot;acc:q9hdc9]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 814\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent synaptosomal-associated protein 29 (snap-29) (vesicle-membrane fusion protein snap-29) (soluble 29 kda nsf attachment protein). [source:swissprot;acc:o95721]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 815\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent syntaxin 1b. [source:swissprot;acc:q15531]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 816\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent melanoma antigen p15 (melanoma-associated antigen recognized by t lymphocytes). [source:swissprot;acc:q13084]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 817\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent dna-binding protein rfxank (regulatory factor x subunit b) (rfx-b) (ankyrin repeat family a protein 1). [source:swissprot;acc:o14593]\vspace{3pt}}&&&\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 818\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [source:swissprot;acc:q9nzl6]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 168.592\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 161.452\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.04422\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 819\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent dna-directed rna polymerase ii 14.5 kda polypeptide (ec 2.7.7.6) (rpb9) (rpb14.5). [source:swissprot;acc:p36954]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 228.563\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 238.668\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.04421\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 820\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent mitochondrial 28s ribosomal protein s2 (mrp-s2) (cgi-91). [source:swissprot;acc:q9y399]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 221.716\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 231.501\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.04413\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 821\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent u3 snornp protein 4 homolog. [source:refseq;acc:nm\_033416]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 221.676\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 231.453\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.0441\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 822\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent eukaryotic translation initiation factor 3 subunit 9 (eif-3 eta) (eif3 p116) (eif3 p110) (eif3b). [source:swissprot;acc:p55884]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 243.067\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 232.805\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.04408\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 823\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent transcription factor iib. [source:refseq;acc:nm\_013242]\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent 206.068\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent 197.471\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent 1.04354\vspace{3pt}}}\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 824\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent splicing factor, arginine/serine-rich 8 (suppressor of white apricot protein homolog). [source:swissprot;acc:q12872]\vspace{3pt}}&&&\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 825\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [source:swissprot;acc:o43516]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 206.214\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 197.614\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.04352\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 826\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent 60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [source:swissprot;acc:q92993]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 223.186\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 213.912\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.04335\vspace{3pt}}\\\hline nd{longtable}
Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/