Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene Hugo description Network Comparison Type Value Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1701 to 1750 of 6456 in total
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1
Rank
Hugo
description
Network Comparison Type
red
green
network_comparison
851 KIAA1012 trs85 homolog. [swissprot;acc:q9y2l5] Divided 107.842 112.329 1.04161
MYCN n-myc proto-oncogene protein. [swissprot;acc:p04198] Subtracted 227.601 219.008 8.593
852 GABPA ga binding protein alpha chain (gabp-alpha subunit) (transcription factor e4tf1-60) (nuclear respiratory factor-2 subunit alpha). [swissprot;acc:q06546] 227.596 219.017 8.579
HPRT1 hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [swissprot;acc:p00492] Divided 193.114 185.412 1.04154
853 no value ga binding protein beta-2 chain (gabp-beta-2 subunit) (transcription factor e4tf1-47) (gapbp-2) (nuclear respiratory factor-2 subunit gamma). [swissprot;acc:q06545] Subtracted 227.596 219.017 8.579
WDR33 wd-repeat protein wdc146. [swissprot;acc:q9c0j8] Divided 108.289 112.772 1.0414
854 CPSF1 cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]
NDUFS8 nadh-ubiquinone oxidoreductase 23 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-23kd) (ci-23kd) (tyky subunit). [swissprot;acc:o00217] Subtracted 227.596 219.017 8.579
855 CLEC3B tetranectin precursor (tn) (plasminogen-kringle 4 binding protein). [swissprot;acc:p05452] Divided 178.514 171.42 1.04138
ELOVL1 elongation of very long chain fatty acids protein 1 (cgi-88). [swissprot;acc:q9bw60] Subtracted 227.596 219.018 8.578
856 MYC myc proto-oncogene protein (c-myc). [swissprot;acc:p01106] 227.585 219.037 8.548
XPR1 xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736] Divided 215.028 206.623 1.04068
857 MDN1 midasin (midas-containing protein). [swissprot;acc:q9nu22] Subtracted 237.218 228.698 8.52
PNO1 putatative 28 kda protein. [refseq;acc:nm_020143] Divided 227.241 236.467 1.0406
858 SRP68 signal recognition particle 68 kda protein (srp68). [swissprot;acc:q9uhb9] Subtracted 221.306 212.806 8.5
STX12 syntaxin 12. [refseq;acc:nm_177424] Divided 217.446 208.997 1.04043
859 no value 60s ribosomal protein l39. [swissprot;acc:p02404] 234.025 224.958 1.04031
nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333] Subtracted 50.7983 42.3003 8.498
860 60s ribosomal protein l18a. [swissprot;acc:q02543] Divided 234.025 224.958 1.04031
NOL6 nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917] Subtracted 242.024 233.544 8.48
861 RPS19 40s ribosomal protein s19. [swissprot;acc:p39019] Divided 234.025 224.958 1.04031
STX12 syntaxin 12. [refseq;acc:nm_177424] Subtracted 217.446 208.997 8.449
862 PKM2 pyruvate kinase, m1 isozyme (ec 2.7.1.40) (pyruvate kinase muscle isozyme) (cytosolic thyroid hormone-binding protein) (cthbp) (thbp1). [swissprot;acc:p14618] 231.357 239.778 8.421
RPL31 60s ribosomal protein l31. [swissprot;acc:p12947] Divided 234.025 224.958 1.04031
863 CSNK2A1P casein kinase ii, alpha chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19138] 240.194 230.957 1.03999
XPR1 xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736] Subtracted 215.028 206.623 8.405
864 CSNK2A2 casein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19784] Divided 240.194 230.957 1.03999
EXOC4 exocyst complex component sec8. [swissprot;acc:q96a65] Subtracted 217.762 209.449 8.313
865 BTF3 transcription factor btf3 (rna polymerase b transcription factor 3). [swissprot;acc:p20290] Divided 211.961 203.814 1.03997
ZNF174 zinc finger protein 174 (aw-1). [swissprot;acc:q15697] Subtracted 269.963 278.239 8.276
866 no value zinc finger imprinted 2. [swissprot;acc:q9nzv7] 269.96 278.232 8.272
SRP68 signal recognition particle 68 kda protein (srp68). [swissprot;acc:q9uhb9] Divided 221.306 212.806 1.03994
867 no value 40s ribosomal protein s3a. [swissprot;acc:p49241] 225.689 234.674 1.03981
ZNF18 zinc finger protein 18 (zinc finger protein kox11) (fragment). [swissprot;acc:p17022] Subtracted 269.956 278.223 8.267
868 MVD diphosphomevalonate decarboxylase (ec 4.1.1.33) (mevalonate pyrophosphate decarboxylase) (mevalonate (diphospho)decarboxylase). [swissprot;acc:p53602] Divided 233.298 242.571 1.03975
ZNF215 zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58] Subtracted 269.956 278.223 8.267
869 EXOC4 exocyst complex component sec8. [swissprot;acc:q96a65] Divided 217.762 209.449 1.03969
ZNF24 zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028] Subtracted 269.955 278.221 8.266
870 no value transcription factor btf3 homolog 3. [swissprot;acc:q13892] Divided 211.908 203.832 1.03962
ZSCAN12 zinc finger protein 305. [swissprot;acc:o43309] Subtracted 269.954 278.219 8.265
871 CPSF2 cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0] Divided 110.2 114.552 1.03949
ZNF232 zinc finger protein 232. [swissprot;acc:q9uny5] Subtracted 269.954 278.218 8.264
872 HNRPK heterogeneous nuclear ribonucleoprotein k (hnrnp k) (dc-stretch binding protein) (csbp) (transformation upregulated nuclear protein) (tunp). [swissprot;acc:q07244] Divided 224.413 233.272 1.03948
ZNF394 zinc finger protein 99. [refseq;acc:nm_032164] Subtracted 269.954 278.218 8.264
873 PRPF4 u4/u6 small nuclear ribonucleoprotein prp4 (u4/u6 snrnp 60 kda protein) (wd splicing factor prp4) (hprp4). [swissprot;acc:o43172] Divided 224.413 233.272 1.03948
ZNF213 zinc finger protein 213 (putative transcription factor cr53). [swissprot;acc:o14771] Subtracted 269.954 278.217 8.263
874 PRKAG1 5'-amp-activated protein kinase, gamma-1 subunit (ampk gamma-1 chain) (ampkg). [swissprot;acc:p54619] Divided 212.002 203.954 1.03946
ZNF274 zinc finger protein 274 (zinc finger protein sp2114) (zinc finger protein hfb101) (zinc finger protein zfp2) (zf2). [swissprot;acc:q96gc6] Subtracted 269.953 278.215 8.262
875 JUP junction plakoglobin (desmoplakin iii). [swissprot;acc:p14923] 223.906 215.653 8.253
PRKAA2 5'-amp-activated protein kinase, catalytic alpha-2 chain (ec 2.7.1.-) (ampk alpha-2 chain). [swissprot;acc:p54646] Divided 212.002 203.954 1.03946

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/