MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1562 to 1611 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
781	MRTO4	ribosomal protein p0-like protein; 60s acidic ribosomal protein po; ribosomal protein, large, p0-like. [refseq;acc:nm_016183]	Divided	245.84	257.636	1.04798
782	no value	translin. [swissprot;acc:q15631]		224.385	235.131	1.04789
	PSIP1	pc4 and sfrs1 interacting protein 2; pc4 and sfrs1 interacting protein 1; transcriptional coactivator p52/p75. [refseq;acc:nm_033222]	Subtracted	231.734	222.222	9.512
783	RPL8	60s ribosomal protein l8. [swissprot;acc:p25120]
	TSNAX	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]	Divided	224.385	235.131	1.04789
784	HDGF	hepatoma-derived growth factor (hdgf) (high-mobility group protein 1- like 2) (hmg-1l2). [swissprot;acc:p51858]	Subtracted	231.734	222.222	9.512
	PQBP1	polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [refseq;acc:nm_005710]	Divided	224.385	235.131	1.04789
785	HDGFL1	pwwp domain containing 1; hdgf (hepatoma-derived growth factor) like. [refseq;acc:nm_138574]	Subtracted	231.734	222.222	9.512
	NET1	neuroepithelial cell transforming gene 1; guanine nucleotide regulatory protein (oncogene); rho guanine nucleotide exchange factor (gef) 8. [refseq;acc:nm_005863]	Divided	244.447	233.508	1.04685
786	ARHGEF3	rho guanine nucleotide exchange factor 3; rhogef protein; 59.8 kda protein; exchange factor found in platelets and leukemic and neuronal tissues, xpln. [refseq;acc:nm_019555]
	DDX6	probable atp-dependent rna helicase p54 (oncogene rck) (dead-box protein 6). [swissprot;acc:p26196]	Subtracted	231.734	222.222	9.512
787	TMEM131	rw1 protein (fragment). [swissprot;acc:q92545]
	UTP20	down-regulated in metastasis. [refseq;acc:nm_014503]	Divided	244.447	233.508	1.04685
788	LOH12CR1	loh1cr12. [refseq;acc:nm_058169]	Subtracted	230.087	220.579	9.508
	NFU1	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	Divided	138.705	132.538	1.04653
789	no value	40s ribosomal protein sa (p40) (34/67 kda laminin receptor) (colon carcinoma laminin-binding protein) (nem/1chd4) (multidrug resistance- associated protein mgr1-ag). [swissprot;acc:p08865]		224.244	234.511	1.04578
	CSDE1	unr protein. [swissprot;acc:o75534]	Subtracted	230.087	220.579	9.508
790	RPS21	40s ribosomal protein s21. [swissprot;acc:p35265]	Divided	224.244	234.511	1.04578
	TEX28P2	testis-specific protein tex28. [swissprot;acc:o15482]	Subtracted	212.386	221.785	9.399
791	C3orf60	similar to nuclear protein e3-3 orf1. [sptrembl;acc:q9bu61]
	SERPINB9	cytoplasmic antiproteinase 3 (cap3) (cap-3) (protease inhibitor 9) (serpin b9). [swissprot;acc:p50453]	Divided	224.244	234.511	1.04578
792	no value	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]
	NEGR1	a kindred of iglon. [refseq;acc:nm_173808]	Subtracted	212.386	221.785	9.399
793	ANKRA2	ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]
	SERPINB10	bomapin (protease inhibitor 10) (serpin b10). [swissprot;acc:p48595]	Divided	224.244	234.511	1.04578
794	GPR84	inflammation-related g protein-coupled receptor ex33. [refseq;acc:nm_020370]	Subtracted	212.386	221.785	9.399
	SERPINB8	plasminogen activator inhibitor-2 precursor (pai-2) (placental plasminogen activator inhibitor) (monocyte arg-serpin) (urokinase inhibitor). [swissprot;acc:p05120]	Divided	224.244	234.511	1.04578
795	no value	serpin b11. [swissprot;acc:q96p15]
	PPT1	palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [swissprot;acc:p50897]	Subtracted	212.386	221.785	9.399
796	NAPB	beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115]
	SERPINB6	placental thrombin inhibitor (cytoplasmic antiproteinase) (cap) (protease inhibitor 6) (pi-6). [swissprot;acc:p35237]	Divided	224.244	234.511	1.04578
797	no value	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]
	STX16	syntaxin 16 (syn16). [swissprot;acc:o14662]	Subtracted	212.386	221.785	9.399
798	GOSR2	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]
	SERPINB1	leukocyte elastase inhibitor (lei) (monocyte/neutrophil elastase inhibitor) (m/nei) (ei). [swissprot;acc:p30740]	Divided	224.244	234.511	1.04578
799	SQSTM1	sequestosome 1; ubiquitin-binding protein p62; phosphotyrosine independent ligand for the lck sh2 domain p62. [refseq;acc:nm_003900]		221.965	212.404	1.04501
	STX1A	syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623]	Subtracted	212.386	221.785	9.399
800	NAPA	alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]
	SCP2	nonspecific lipid-transfer protein, mitochondrial precursor (nsl-tp) (sterol carrier protein 2) (scp-2) (sterol carrier protein x) (scp-x) (scpx). [swissprot;acc:p22307]	Divided	221.965	212.404	1.04501
801	C20orf3	adipocyte plasma membrane-associated protein (bscv protein). [swissprot;acc:q9hdc9]	Subtracted	212.386	221.785	9.399
	CTNNB1	beta-catenin (pro2286). [swissprot;acc:p35222]	Divided	224.445	214.894	1.04445
802	SNAP29	synaptosomal-associated protein 29 (snap-29) (vesicle-membrane fusion protein snap-29) (soluble 29 kda nsf attachment protein). [swissprot;acc:o95721]	Subtracted	212.386	221.785	9.399
	TEX28P2	testis-specific protein tex28. [swissprot;acc:o15482]	Divided			1.04425
803	C3orf60	similar to nuclear protein e3-3 orf1. [sptrembl;acc:q9bu61]
	STX1B	syntaxin 1b. [swissprot;acc:q15531]	Subtracted			9.399
804	MRPL28	melanoma antigen p15 (melanoma-associated antigen recognized by t lymphocytes). [swissprot;acc:q13084]
	NEGR1	a kindred of iglon. [refseq;acc:nm_173808]	Divided			1.04425
805	ANKRA2	ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]
	RFXANK	dna-binding protein rfxank (regulatory factor x subunit b) (rfx-b) (ankyrin repeat family a protein 1). [swissprot;acc:o14593]	Subtracted			9.399
806	GPR84	inflammation-related g protein-coupled receptor ex33. [refseq;acc:nm_020370]	Divided			1.04425

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.