Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene Hugo description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 713 to 762 of 3228 in total
Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
Rank
Hugo
description
red
green
network_comparison
713 EIF3M dendritic cell protein. [refseq;acc:nm_006360] 223.121 211.685 1.05402
714 CPXM2 potential carboxypeptidase-like protein x2 precursor. [swissprot;acc:q8n436]
715 CPN1 carboxypeptidase n catalytic chain precursor (ec 3.4.17.3) (arginine carboxypeptidase) (kininase 1) (serum carboxypeptidase n) (scpn) (anaphylatoxin inactivator) (plasma carboxypeptidase b). [swissprot;acc:p15169]
716 CPZ cpz gene product. [refseq;acc:nm_003652]
717 CPE carboxypeptidase h precursor (ec 3.4.17.10) (cph) (carboxypeptidase e) (cpe) (enkephalin convertase) (prohormone processing carboxypeptidase). [swissprot;acc:p16870]
718 CPXM1 potential carboxypeptidase x precursor (ec 3.4.17.-) (metallocarboxypeptidase cpx-1). [swissprot;acc:q96sm3]
719 NOL5A nucleolar protein nop56 (nucleolar protein 5a). [swissprot;acc:o00567] 247.769 235.074 1.054
720 RPLP2 60s acidic ribosomal protein p2. [swissprot;acc:p05387] 231.92 244.435 1.05396
721 EXOC5 exocyst complex component sec10 (hsec10). [swissprot;acc:o00471] 214.765 203.8 1.0538
722 TREH trehalase precursor (ec 3.2.1.28) (alpha,alpha-trehalase) (alpha,alpha-trehalose glucohydrolase). [swissprot;acc:o43280] 217.952 206.902 1.05341
723 no value histone h3.3 (h3.a) (h3.b) (h3.3q). [swissprot;acc:p06351] 244.842 232.577 1.05274
724 dj1099d15.1 (putative dnaj protein). [sptrembl;acc:q9h4j9]
725 MVK mevalonate kinase (ec 2.7.1.36) (mk). [swissprot;acc:q03426] 235.296 247.673 1.0526
726 FTSJ3 ftsj homolog 3; likely ortholog of mouse ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 3. [refseq;acc:nm_017647] 244.495 232.419 1.05196
727 NUAK1 probable serine/threonine-protein kinase kiaa0537 (ec 2.7.1.-). [swissprot;acc:o60285] 208.873 219.71 1.05188
728 B3GNT1 n-acetyllactosaminide beta-1,3-n-acetylglucosaminyltransferase (ec 2.4.1.149) (poly-n-acetyllactosamine extension enzyme) (i-beta- 1,3-n-acetylglucosaminyltransferase) (ignt) (udp-glcnac:betagal beta- 1,3-n-acetylglucosaminyltransferase 6). [swissprot;acc:o43505] 208.874 219.708 1.05187
729 no value huntingtin interacting protein e; huntingtin interactor protein e. [refseq;acc:nm_007076]
730 TIMM10 mitochondrial import inner membrane translocase subunit tim10. [swissprot;acc:q9y5j8]
731 FH fumarate hydratase, mitochondrial precursor (ec 4.2.1.2) (fumarase). [swissprot;acc:p07954]
732 SEPT8 septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599] 124.434 118.318 1.05169
733 ACADVL acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748] 164 155.961 1.05154
734 no value presenilin-like protein 2 (ec 3.4.99.-) (sppl2a protein). [swissprot;acc:q8tct8] 232.601 244.534 1.0513
735 RANP1 gtp-binding nuclear protein ran (tc4) (ran gtpase) (androgen receptor- associated protein 24). [swissprot;acc:p17080]
736 no value presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]
737 SEPT10 septin 10 isoform 1. [refseq;acc:nm_144710] 125.526 119.402 1.05129
738 XAB2 xpa-binding protein 2 (hcnp protein) (pp3898). [swissprot;acc:q9hcs7] 222.825 211.966 1.05123
739 PFAS phosphoribosylformylglycinamidine synthase (ec 6.3.5.3) (fgam synthase) (fgams) (formylglycinamide ribotide amidotransferase) (fgarat) (formylglycinamide ribotide synthetase). [swissprot;acc:o15067] 223.58 235.027 1.0512
740 ATIC bifunctional purine biosynthesis protein purh [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (ec 2.1.2.3) (aicar transformylase); imp cyclohydrolase (ec 3.5.4.10) (inosinicase) (imp synthetase) (atic)]. [swissprot;acc:p31939]
741 PAICS multifunctional protein ade2 [includes: phosphoribosylaminoimidazole- succinocarboxamide synthase (ec 6.3.2.6) (saicar synthetase); phosphoribosylaminoimidazole carboxylase (ec 4.1.1.21) (air carboxylase) (airc)]. [swissprot;acc:p22234]
742 BRP44 brain protein 44. [swissprot;acc:o95563] 126.215 120.078 1.05111
743 SEPT7 septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]
744 SEPT6 septin 6. [swissprot;acc:q14141] 126.604 120.463 1.05098
745 SLC35B1 solute carrier family 35, member b1; udp-galactose transporter related. [refseq;acc:nm_005827] 214.679 225.568 1.05072
746 EIF3I eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [swissprot;acc:q13347] 250.465 238.38 1.0507
747 no value trinucleotide repeat containing 15. [refseq;acc:nm_015575]
748 FBL fibrillarin (34 kda nucleolar scleroderma antigen). [swissprot;acc:p22087] 245.246 233.483 1.05038
749 EXOC6B exocyst complex component sec15b. [swissprot;acc:q9y2d4] 221.968 211.326 1.05036
750 EXOC6 exocyst complex component sec15a. [swissprot;acc:q8tag9] 222.138 211.503 1.05028
751 no value u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695] 223.463 212.875 1.04974
752 SLU7 step ii splicing factor slu7. [refseq;acc:nm_006425]
753 LBP lipopolysaccharide-binding protein precursor (lbp). [swissprot;acc:p18428] 224.434 235.583 1.04968
754 SPCS2 microsomal signal peptidase 25 kda subunit (ec 3.4.-.-) (spase 25 kda subunit) (spc25). [swissprot;acc:q15005]
755 UMPS uridine 5'-monophosphate synthase (ump synthase) [includes: orotate phosphoribosyltransferase (ec 2.4.2.10) (oprtase); orotidine 5'- phosphate decarboxylase (ec 4.1.1.23) (ompdecase)]. [swissprot;acc:p11172]
756 CLPTM1 cleft lip and palate associated transmembrane protein 1. [refseq;acc:nm_001294]
757 BPI bactericidal permeability-increasing protein precursor (bpi) (cap 57). [swissprot;acc:p17213]
758 PLTP phospholipid transfer protein precursor (lipid transfer protein ii). [swissprot;acc:p55058]
759 OSTF1 osteoclast stimulating factor 1. [swissprot;acc:q92882] 231.809 243.289 1.04952
760 NAT10 upf0202 protein kiaa1709. [swissprot;acc:q9h0a0] 246.055 234.458 1.04946
761 CBLB signal transduction protein cbl-b (sh3-binding protein cbl-b). [swissprot;acc:q13191] 213.325 203.303 1.0493
762 CBL cbl e3 ubiquitin protein ligase (ec 6.3.2.-) (signal transduction protein cbl) (proto-oncogene c-cbl). [swissprot;acc:p22681] 213.256 203.237

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/