MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Filtered	Value Type	Network Comparison Type	network_comparison	Interaction Map	Rank	description	red	green

Results: HTML CSV LaTeX

Showing element 1001 to 1050 of 77072 in total

Filtered  : 0
Value Type  : Measured
Network Comparison Type  : Divided

network_comparison	Interaction Map	Rank	description	red	green
1.23065	Low confidence	167	spectrin beta chain, brain 4 (spectrin, non-erythroid beta chain 4) (beta-v spectrin) (bspecv). [swissprot;acc:q9nrc6]	4088.01	3321.82
1.23201		166	elongation of very long chain fatty acids protein 2. [swissprot;acc:q9nxb9]	1208.65	1489.07
1.23523	High confidence	178	dj947l8.1.1 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4v7]	498.07	615.233
	Low confidence	165
1.23683	High confidence	177	acrc protein; putative nuclear protein. [refseq;acc:nm_052957]	4131.06	3340.03
1.2405	Low confidence	164	myotubularin related protein 8. [refseq;acc:nm_017677]	3888.6	4823.8
1.24111	High confidence	176	small glutamine rich protein with tetratricopeptide repeats 2. [refseq;acc:nm_019072]	3023.85	2436.4
1.24677	Low confidence	163	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	1113.87	1388.74
1.24887	High confidence	175	cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [refseq;acc:nm_015247]	1382.5	1107
	Low confidence	162
1.25		161	protein c20orf142 precursor. [swissprot;acc:q8n6m3]	76	95
1.25401		160	testican-3 precursor. [swissprot;acc:q9bq16]	642.672	805.916
1.25423	High confidence	174	dj947l8.1.6 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4w2]	488.43	612.604
	Low confidence	159
1.25474		158	rho guanine nucleotide exchange factor (gef) 12; leukemia-associated rho guanine nucleotide exchange factor. [refseq;acc:nm_015313]	752.839	944.615
1.25567		157	brca1 associated protein. [refseq;acc:nm_006768]	1117.36	1403.03
1.25656	High confidence	173	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	3265.25	4102.97
1.25772		170	williams-beuren syndrome critical region protein 20 copy b. [refseq;acc:nm_145645]	112.666	141.702
		171	williams beuren syndrome critical region 20a isoform 2; nol1/nop2/sun gene family member; williams-beuren syndrome critical region protein 20 copy a; williams beuren syndrome chromosome region 20. [refseq;acc:nm_018044]
		172	williams beuren syndrome chromosome region 20c isoform 1. [refseq;acc:nm_032158]
1.25773		169	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	244	194
1.2585		168	transcription factor mafg (v-maf musculoaponeurotic fibrosarcoma oncogene homolog g) (hmaf). [swissprot;acc:o15525]	334.012	420.355
1.25858	Low confidence	156	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]	1683.2	2118.44
1.26047	High confidence	167	transcription factor mafk (erythroid transcription factor nf-e2 p18 subunit). [swissprot;acc:o60675]	331.61	417.983
1.2611		166	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	5629.62	7099.51
1.26251		165	mto1 protein homolog (cgi-02). [swissprot;acc:q9y2z2]	1002.2	793.818
1.26273	Low confidence	155	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	4230.36	5341.81
1.26383	High confidence	164	aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]	1711.55	1354.26
1.26419	Low confidence	153	candidate tumor suppressor protein. [refseq;acc:nm_020381]	2232	2821.67
		154	supervillin isoform 1; membrane-associated f-actin binding protein p205; archvillin. [refseq;acc:nm_003174]
1.26442	High confidence	163	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	7830.62	6193.07
1.26468		162	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	5734.28	7252.02
1.26579	Low confidence	152		4660.09	5898.71
1.26808		151	williams-beuren syndrome critical region protein 20 copy b. [refseq;acc:nm_145645]	410.457	323.685
1.26852		150	williams beuren syndrome chromosome region 20c isoform 1. [refseq;acc:nm_032158]	410.28	323.433
1.26875		149	glycine cleavage system h protein, mitochondrial precursor. [swissprot;acc:p23434]	745.137	945.391
1.26947		148	williams beuren syndrome critical region 20a isoform 2; nol1/nop2/sun gene family member; williams-beuren syndrome critical region protein 20 copy a; williams beuren syndrome chromosome region 20. [refseq;acc:nm_018044]	409.972	322.947
1.27473	High confidence	161	glycine cleavage system h protein, mitochondrial precursor. [swissprot;acc:p23434]	903.767	1152.06
1.27566		160	huntingtin interacting protein c. [refseq;acc:nm_012272]	1653.74	1296.38
1.27796		159	lipocalin-interacting membrane receptor. [refseq;acc:nm_018113]	734.025	574.372
1.28372	Low confidence	147	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	1310	1681.67
1.28508	High confidence	158	guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388]	1283.48	1649.37
1.28522	Low confidence	146	adenosine deaminase (ec 3.5.4.4) (adenosine aminohydrolase). [swissprot;acc:p00813]	1073.89	835.57
1.28761		145	lipocalin-interacting membrane receptor. [refseq;acc:nm_018113]	553.827	430.121
1.2878		144	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	749.494	965.202
1.28908	High confidence	157	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	261.105	336.584
	Low confidence	143
1.28932	High confidence	151	udp-glucuronosyltransferase 2b17 precursor, microsomal (ec 2.4.1.17) (udpgt) (c19-steroid specific udp-glucuronosyltransferase). [swissprot;acc:o75795]	2230.13	1729.7
		152	udp-glucuronosyltransferase 2b11 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:o75310]
		153	udp-glucuronosyltransferase 2b4 precursor, microsomal (ec 2.4.1.17) (udpgt) (hyodeoxycholic acid) (hlug25) (udpgth-1). [swissprot;acc:p06133]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.