MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	description	Rank	Value Type	Network Comparison Type	Filtered	Interaction Map	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 6858 to 6907 of 7460 in total

Value Type  : Measured
Interaction Map  : High confidence

description	Rank	Network Comparison Type	Filtered	red	network_comparison	green
tropomyosin 1 alpha chain (alpha-tropomyosin). [swissprot;acc:p09493]	2945	Subtracted	1	0	0	0
tropomyosin alpha 3 chain (tropomyosin 3) (tropomyosin gamma). [swissprot;acc:p06753]	2931	Divided		0.00001	1	0.00001
		Subtracted		0	0	0
tropomyosin alpha 4 chain (tropomyosin 4) (tm30p1). [swissprot;acc:p07226]	2833	Divided		0.00001	1	0.00001
		Subtracted		0	0	0
trs85 homolog. [swissprot;acc:q9y2l5]	47			24896.4	4464.7	20431.7
	263	Divided			1.21852
trub pseudouridine (psi) synthase homolog 1. [refseq;acc:nm_139169]	2698			4163.36	1.0042	4145.95
	2736	Subtracted			17.41
tryptophan 2,3-dioxygenase (ec 1.13.11.11) (tryptophan pyrrolase) (tryptophanase) (tryptophan oxygenase) (tryptamin 2,3-dioxygenase) (trpo). [swissprot;acc:p48775]	890	Divided		5350.87	1.10203	5896.82
	983	Subtracted			545.95
tryptophanyl-trna synthetase (ec 6.1.1.2) (tryptophan--trna ligase) (trprs) (ifp53) (hwrs). [swissprot;acc:p23381]	1483	Divided		5372.25	1.07501	5775.21
	1684	Subtracted			402.96
tryptophanyl-trna synthetase, mitochondrial precursor (ec 6.1.1.2) (tryptophan--trna ligase) (trprs) ((mt)trprs). [swissprot;acc:q9ugm6]	1485	Divided			1.07501
	1686	Subtracted			402.96
tsc22-related inducible leucine zipper protein 2 (tsc-22-like protein thg-1). [swissprot;acc:q9y3q8]	1197			5873.56	496.75	6370.31
	1237	Divided			1.08457
tu12b1-ty protein. [refseq;acc:nm_016575]	3074			0.00001	1	0.00001
		Subtracted		0	0	0
tubby protein homolog. [swissprot;acc:p50607]	71		0	3797.57	430.7	4228.27
	289	Divided			1.11341
	561	Subtracted	1	6374.65	770.94	7145.59
	663	Divided			1.12094
tubby related protein 1 (tubby-like protein 1). [swissprot;acc:o00294]	565	Subtracted			770.94
	667	Divided			1.12094
tubby related protein 3 (tubby-like protein 3). [swissprot;acc:o75386]	568	Subtracted			770.94
	670	Divided			1.12094
tubulin alpha-3/alpha-7 chain (alpha-tubulin 3/7). [swissprot;acc:p05214]	3175			0.00001	1	0.00001
		Subtracted		0	0	0
tubulin gamma-1 chain (gamma-1 tubulin) (gamma-tubulin complex component 1) (gcp-1). [swissprot;acc:p23258]	47		0	3645.5	527.2	3118.3
	218	Divided			1.16907
	2264	Subtracted	1	6327.14	252.24	6579.38
	2390	Divided			1.03987
tubulin gamma-2 chain (gamma-2 tubulin). [swissprot;acc:q9nrh3]	2267	Subtracted			252.24
	2393	Divided			1.03987
tubulin tyrosine ligase-like protein 1. [swissprot;acc:o95922]	3141			0.00001	1	0.00001
		Subtracted		0	0	0
tubulin tyrosine ligase-like protein hottl (hqp0207). [swissprot;acc:q9y4r7]	1796	Divided		5387.64	1.06605	5743.5
	1944	Subtracted			355.86
tubulin-specific chaperone a (tubulin-folding cofactor a) (cfa) (tcp1-chaperonin cofactor a). [swissprot;acc:o75347]	2817	Divided		0.00001	1	0.00001
		Subtracted		0	0	0
tubulin-specific chaperone c (tubulin-folding cofactor c) (cfc). [swissprot;acc:q15814]	1039			5719.01	529.59	6248.6
	1059	Divided			1.0926
tubulin-tyrosine ligase. [refseq;acc:nm_153712]	922			5511.2	1.09862	6054.71
	987	Subtracted			543.51
tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	290	Divided		4991.48	1.20487	6014.08
	343	Subtracted			1022.6
tumor differentially expressed 1 protein like. [swissprot;acc:q9nrx5]	938			6133.83	556.35	6690.18
	1100	Divided			1.0907
tumor differentially expressed protein 1 (transmembrane protein sbbi99). [swissprot;acc:q13530]	937	Subtracted			556.35

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.