MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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description	Rank	Gene	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 6408 to 6457 of 7460 in total

Value Type  : Ranked
Interaction Map  : High confidence

description	Rank	Network Comparison Type	Filtered	red	green	network_comparison
t-box transcription factor tbx1 (t-box protein 1) (testis-specific t-box protein). [swissprot;acc:o43435]	2771	Subtracted	1	0	0	0
t-box transcription factor tbx19 (t-box protein 19). [swissprot;acc:o60806]	2042	Divided		210.586	208.803	1.00854
	2044	Subtracted				1.783
t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	427			212.547	229.411	16.864
	434	Divided				1.07934
t-cell activation wd repeat protein. [refseq;acc:nm_139281]	896	Subtracted		243.34	235.322	8.018
	976	Divided				1.03407
t-cell acute lymphocytic leukemia-1 protein (tal-1 protein) (stem cell protein) (t-cell leukemia/lymphoma-5 protein). [swissprot;acc:p17542]	2865			0.00001	0.00001	1
		Subtracted		0	0	0
t-cell acute lymphocytic leukemia-2 protein (tal-2 protein). [swissprot;acc:q16559]	2760	Divided		0.00001	0.00001	1
		Subtracted		0	0	0
t-cell leukemia homeobox protein 1 (homeobox protein hox-11) (tcl-3 proto-oncogene). [swissprot;acc:p31314]	502			237.28	252.492	15.212
	585	Divided				1.06411
t-cell leukemia homeobox protein 2 (homeobox protein hox-11l1) (neural crest homeobox protein). [swissprot;acc:o43763]	501	Subtracted				15.212
	584	Divided				1.06411
t-cell leukemia homeobox protein 3 (homeobox protein hox-11l2). [swissprot;acc:o43711]	498	Subtracted				15.212
	581	Divided				1.06411
t-complex 11. [refseq;acc:nm_018679]	1741			206.595	209.258	1.01289
	1765	Subtracted				2.663
t-complex associated-testis-expressed 1-like (protein 91/23). [swissprot;acc:p51808]	1044	Divided		173.475	178.889	1.03121
	1171	Subtracted				5.414
t-complex protein 1, alpha subunit (tcp-1-alpha) (cct-alpha). [swissprot;acc:p17987]	689	Divided		135.379	128.225	1.05579
	956	Subtracted				7.154
t-complex protein 1, delta subunit (tcp-1-delta) (cct-delta) (stimulator of tar rna binding). [swissprot;acc:p50991]	285	Divided		224.647	203.242	1.10532
	331	Subtracted				21.405
t-complex protein 1, epsilon subunit (tcp-1-epsilon) (cct-epsilon). [swissprot;acc:p48643]	1040	Divided		163.24	168.359	1.03136
	1261	Subtracted				5.119
t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	397	Divided		110.689	101.613	1.08932
	817	Subtracted				9.076
t-complex protein 1, zeta subunit (tcp-1-zeta) (cct-zeta) (cct-zeta-1) (tcp20) (htr3). [swissprot;acc:p40227]	170		0	12715.9	11333.2	1382.7
	192	Divided				1.122
	2917		1	0.00001	0.00001	1
		Subtracted		0	0	0
t-complex protein 1, zeta-2 subunit (tcp-1-zeta-2) (cct-zeta-2) (tcp- 1-zeta-like) (cct-zeta-like) (testis-specific tcp20) (testis-specific protein tsa303). [swissprot;acc:q92526]	2995	Divided		0.00001	0.00001	1
		Subtracted		0	0	0
t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	42			332.874	267.246	65.628
	112	Divided				1.24557
t54 protein. [swissprot;acc:q92917]	554	Subtracted		226.3	212.38	13.92
	569	Divided				1.06554
tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	104	Subtracted		256.228	298.438	42.21
	180	Divided				1.16474
target of egr1, member 1 (nuclear); target of egr1, member 1. [refseq;acc:nm_025077]	1013	Subtracted		217.365	210.558	6.807
	1017	Divided				1.03233
target of myb protein 1. [swissprot;acc:o60784]	934	Subtracted		217.254	209.824	7.43
	948	Divided				1.03541
target of myb1-like 2; target of myb1 (chicken) homolog-like 2. [refseq;acc:nm_144678]	937	Subtracted		217.252	209.83	7.422
	952	Divided				1.03537
tata box binding protein (transcription initiation factor tfiid) (tata-box factor) (tata sequence-binding protein) (tbp). [swissprot;acc:p20226]	2262	Subtracted		211.597	210.416	1.181
	2267	Divided				1.00561
tata box binding protein-associated factor, rna polymerase ii, q; taf7-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 50 kd; tbp-associated factor, rna polymerase ii, q. [refseq;acc:nm_024885]	382			200.791	183.66	1.09328

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.