MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Rank	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 601 to 650 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	network_comparison	green
301	beta-1,4 mannosyltransferase. [refseq;acc:nm_019109]	Divided	150.982	1.10193	166.372
	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	Subtracted	88.2482	22.0168	110.265
302	60s ribosomal protein l26. [swissprot;acc:q02877]	Divided	242.326	1.10185	267.008
	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	Subtracted	88.2482	22.0168	110.265
303	60s ribosomal protein l35. [swissprot;acc:p42766]	Divided	242.333	1.10179	266.999
	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Subtracted	88.2482	22.0168	110.265
304	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	Divided	242.339	1.1017	266.986
	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Subtracted	88.2482	22.0168	110.265
305	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]
	mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	Divided	242.339	1.1017	266.986
306	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]		242.153	1.10126	266.673
	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Subtracted	88.2482	22.0168	110.265
307	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]
	serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]	Divided	242.153	1.10126	266.673
308	60s ribosomal protein l34. [swissprot;acc:p49207]
	necdin. [swissprot;acc:q99608]	Subtracted	88.2482	22.0168	110.265
309	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]
	protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3]	Divided	242.153	1.10126	266.673
310	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Subtracted	88.2482	22.0168	110.265
	protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378]	Divided	242.153	1.10126	266.673
311	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Subtracted	88.2482	22.0168	110.265
	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]	Divided	242.627	1.10108	267.151
312	60s ribosomal protein l3-like. [swissprot;acc:q92901]		242.195	1.10103	266.663
	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Subtracted	88.2482	22.0168	110.265
313	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]
	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	Divided	232.473	1.10069	211.207
314	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Subtracted	88.2482	22.0168	110.265
	methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582]	Divided	244.126	1.10027	268.604
315	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Subtracted	88.2482	22.0168	110.265
	methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579]	Divided	244.126	1.10027	268.604
316	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Subtracted	88.2482	22.0168	110.265
	protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567]	Divided	242.694	1.10022	267.017
317	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Subtracted	88.2482	22.0168	110.265
	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	Divided	224.445	1.09998	204.044
318	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Subtracted	88.2482	22.0168	110.265
	mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]	Divided	242.011	1.09987	266.18
319	60s ribosomal protein l19. [swissprot;acc:p14118]		240.73	1.09969	264.729
	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	Subtracted	88.2482	22.0168	110.265
320	epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830]	Divided	241.892	1.0995	265.96
	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	Subtracted	88.2482	22.0168	110.265
321	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	Divided	241.892	1.09949	265.959
	trophinin. [swissprot;acc:q12816]	Subtracted	88.2482	22.0168	110.265
322	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	Divided	86.7483	1.09948	78.8995
	ribonucleoside-diphosphate reductase m2 chain (ec 1.17.4.1) (ribonucleotide reductase small chain). [swissprot;acc:p31350]	Subtracted	231.969	21.905	210.064
323	40s ribosomal protein s14 (pro2640). [swissprot;acc:p06366]		242.238	21.872	264.11
	60s ribosomal protein l23a. [swissprot;acc:p29316]	Divided	241.884	1.09947	265.945
324	40s ribosomal protein s18 (ke-3) (ke3). [swissprot;acc:p25232]	Subtracted	242.238	21.872	264.11
	40s ribosomal protein s23. [swissprot;acc:p39028]	Divided	243.944	1.09941	268.195
325	28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]
	60s ribosomal protein l13, mitochondrial (l13mt). [swissprot;acc:q9byd1]	Subtracted	241.828	21.792	263.62

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.