Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene Value Type description Network Comparison Type Interaction Map red green Filtered network_comparison
Results: HTML CSV LaTeX Showing element 601 to 650 of 7460 in total
Value Type  : Ranked
Interaction Map  : High confidence
Rank
description
Network Comparison Type
red
green
Filtered
network_comparison
151 myosin vc (myosin 5c). [swissprot;acc:q9nqx4] Divided 55 46 1 1.19565
orphan nuclear receptor nr2e1 (nuclear receptor tlx) (tailless homolog) (tll) (htll). [swissprot;acc:q9y466] Subtracted 7234.6 8858.94 0 1624.34
protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22] 226.582 198.444 1 28.138
u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695] Divided 7502.08 6461.83 0 1.16098
152 myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1] 55 46 1 1.19565
putative eukaryotic translation initiation factor 1a (eif-1a) (eif- 4c). [swissprot;acc:o75642] Subtracted 12301.4 10680.5 0 1620.9
similar to ribosomal protein, large, p0. [sptrembl;acc:q96fq9] Divided 11438 13277.1 1.16079
u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621] Subtracted 226.582 198.444 1 28.138
153 chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286] Divided 249.663 298.263 1.19466
filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333] Subtracted 226.582 198.444 28.138
methyltransferase like 2. [refseq;acc:nm_018396] 17946 16326 0 1620
tubulin gamma-1 chain (gamma-1 tubulin) (gamma-tubulin complex component 1) (gcp-1). [swissprot;acc:p23258] Divided 7879.3 6789.92 1.16044
154 musashi 2 isoform a. [refseq;acc:nm_138962] Subtracted 227.491 199.458 1 28.033
myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1] Divided 10883 12622.8 0 1.15986
rab gdp dissociation inhibitor alpha (rab gdi alpha) (gdi-1) (xap-4) (oligophrenin 2). [swissprot;acc:p31150] Subtracted 15395.7 16992.9 1597.2
regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795] Divided 249.663 298.263 1 1.19466
155 musashi 1. [refseq;acc:nm_002442] Subtracted 227.491 199.458 28.033
polyposis locus protein 1-like 1; likely ortholog of mouse polyposis locus protein 1-like 1. [refseq;acc:nm_138393] Divided 12759.4 11028.8 0 1.15692
putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37] 249.663 298.263 1 1.19466
ribulose-5-phosphate-3-epimerase; ribulose 5-phosphate 3-epimerase. [refseq;acc:nm_006916] Subtracted 13248.5 11666.4 0 1582.1
156 nuclear protein ukp68. [refseq;acc:nm_024824] 227.491 199.458 1 28.033
regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081] Divided 249.663 298.263 1.19466
thiamin pyrophosphokinase 1; mouse thiamin pyrophosphokinase homolog; thiamine pyrophosphokinase. [refseq;acc:nm_022445] Subtracted 13248.5 11666.4 0 1582.1
tubby protein homolog. [swissprot;acc:p50607] Divided 12303.7 10641.7 1.15618
157 low affinity immunoglobulin epsilon fc receptor (lymphocyte ige receptor) (fc-epsilon-rii) (cd23) (blast-2) (immunoglobulin e-binding factor). [swissprot;acc:p06734] Subtracted 11364 12941 1577
neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784] 312 284 1 28
transcription factor lbx1. [swissprot;acc:p52954] Divided 249.663 298.263 1.19466
transcription initiation factor iie, beta subunit (tfiie-beta). [swissprot;acc:p29084] 18079 15652 0 1.15506
158 60s ribosomal protein l7. [swissprot;acc:p18124] Subtracted 11080.3 9505.89 1574.41
chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873] 312 284 1 28
mosaic protein lgn. [swissprot;acc:p81274] Divided 249.663 298.263 1.19466
putative nucleoside diphosphate kinase (ec 2.7.4.6) (ndk) (ndp kinase). [swissprot;acc:o60361] 10060.2 11616.4 0 1.15469
159 cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326] 5813.32 6706.32 1.15361
dihydrofolate reductase (ec 1.5.1.3). [swissprot;acc:p00374] Subtracted 11971.7 10412.4 1559.3
doc-1 related protein (doc-1r). [swissprot;acc:o75956] 312 284 1 28
regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6] Divided 249.663 298.263 1.19466
160 ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1] 11732 13530.6 0 1.15331
guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471] 249.663 298.263 1 1.19466
neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8] Subtracted 312 284 28
putative nucleoside diphosphate kinase (ec 2.7.4.6) (ndk) (ndp kinase). [swissprot;acc:o60361] 10060.2 11616.4 0 1556.2
161 cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] Divided 5781.93 6660.63 1.15197
neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562] Subtracted 312 284 1 28
protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236] 15245.4 16788.5 0 1543.1
rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736] Divided 249.663 298.263 1 1.19466
162 atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915] Subtracted 142 170 28
dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9] 13068 11528 0 1540
nostrin. [refseq;acc:nm_052946] Divided 209.299 249.187 1 1.19058
putative eukaryotic translation initiation factor 1a (eif-1a) (eif- 4c). [swissprot;acc:o75642] 12301.4 10680.5 0 1.15176
163 beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121] Subtracted 133 105 1 28
eap30 subunit of ell complex. [refseq;acc:nm_007241] Divided 209.299 249.187 1.19058

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/