MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	description	Rank	Network Comparison Type	Value Type	Interaction Map	green	red	Filtered	network_comparison

Results: HTML CSV LaTeX

Showing element 551 to 600 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Network Comparison Type	green	red	network_comparison
anaphase promoting complex subunit 11 (hepatocellular carcinoma associated ring finger protein) (hspc214). [swissprot;acc:q9nyg5]	2636	Divided	195.384	195.635	1.00128
	2639	Subtracted			0.251
anaphase-promoting complex subunit 10; anaphase-promoting complex 10. [refseq;acc:nm_014885]	2663	Divided	204.549	204.768	1.00107
	2667	Subtracted			0.219
anaphase-promoting complex subunit 2; anaphase-promoting complex 2. [refseq;acc:nm_013366]	2679	Divided	189.959	190.142	1.00096
	2682	Subtracted			0.183
androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	184		254.15	227.357	26.793
	240	Divided			1.11785
angiomotin like 2; leman coiled-coil protein; angiomotin-like protein 2. [refseq;acc:nm_016201]	2586		213.75	213.422	1.00154
		Subtracted			0.328
angiomotin. [refseq;acc:nm_133265]	2585	Divided			1.00154
		Subtracted			0.328
anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	143	Divided	49	59	1.20408
	773	Subtracted			10
ankyrin 2 (brain ankyrin) (ankyrin b) (ankyrin, nonerythroid). [swissprot;acc:q01484]	2516		216.341	215.835	0.506
	2519	Divided			1.00234
ankyrin 3 (ank-3) (ankyrin g). [swissprot;acc:q12955]	2515	Subtracted			0.506
	2518	Divided			1.00234
ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]	793	Subtracted	221.785	212.386	9.399
	805	Divided			1.04425
annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995]	1051	Subtracted	213.378	219.673	6.295
	1088	Divided			1.0295
annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]	1053	Subtracted	213.385	219.655	6.27
	1094	Divided			1.02938
antithrombin-iii precursor (atiii) (pro0309). [swissprot;acc:p01008]	2406	Subtracted	218.984	218.2	0.784
	2418	Divided			1.00359
apg3p; pc3-96 protein. [refseq;acc:nm_022488]	169		98.0548	82.5916	1.18722
	489	Subtracted			15.4632
apical-like protein (apxl protein). [swissprot;acc:q13796]	346		211.136	231.492	20.356
	362	Divided			1.09641
apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	211	Subtracted	212.41	237.302	24.892
	248	Divided			1.11719
apolipoprotein a-i binding protein; apoa-i binding protein. [refseq;acc:nm_144772]	1606		204.662	207.916	1.0159
	1609	Subtracted			3.254
apolipoprotein b-100 precursor (apo b-100) [contains: apolipoprotein b-48 (apo b-48)]. [swissprot;acc:p04114]	2128		219.366	217.871	1.495
	2151	Divided			1.00686
apopain precursor (ec 3.4.22.-) (cysteine protease cpp32) (yama protein) (cpp-32) (caspase-3) (casp-3) (srebp cleavage activity 1) (sca-1). [swissprot;acc:p42574]	1166	Subtracted	228.46	233.942	5.482
	1293	Divided			1.024
apoptosis antagonizing transcription factor. [refseq;acc:nm_012138]	929	Subtracted	235.422	243.045	7.623
	1014	Divided			1.03238
apoptosis inhibitor 5; fibroblast growth factor 2-interacting factor 2; api5-like 1. [refseq;acc:nm_006595]	1094	Subtracted	212.675	218.484	5.809
	1132	Divided			1.02731
apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	1083	Subtracted	212.123	217.99	5.867
	1111	Divided			1.02766
apoptosis-inducing factor (aif)-homologous mitochondrion-associated inducer of death; p53-responsive gene 3. [refseq;acc:nm_032797]	2418	Subtracted	209.454	210.205	0.751
	2421	Divided			1.00359
apurinic/apyrimidinic endonuclease 2; apurinic/apyrimidinic endonuclease-like 2; apex nuclease-like 2. [refseq;acc:nm_014481]	2523	Subtracted	215.787	216.264	0.477
	2531	Divided			1.00221
aquaporin 4 (wch4) (mercurial-insensitive water channel) (miwc). [swissprot;acc:p55087]	2688	Subtracted	188.046	188.191	0.145
	2690	Divided			1.00077

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.