Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank Gene description Value Type Network Comparison Type Interaction Map green Filtered red network_comparison

Results: HTML CSV LaTeX

Showing element 551 to 600 of 7460 in total

Value Type

: Ranked
Interaction Map

: High confidence

Rank	description	Network Comparison Type	green	Filtered	red	network_comparison
138	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	Divided	234.204	1	194.372	1.20493
138	serpin b11. [swissprot;acc:q96p15]	Subtracted	15123	0	16853	1730
139	alpha crystallin a chain. [swissprot;acc:p02489]	Divided	13972.2	0	16372.4	1.17178
	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	Divided	225.68	1	271.752	1.20415
	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	Subtracted	256.835	1	287.41	30.575
	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]		15123	0	16853	1730
140	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]		198.011	1	228.306	30.295
	dipeptidyl peptidase 8 isoform 2; dipeptidyl peptidase 8. [refseq;acc:nm_017743]		16802.1	0	15081.8	1720.3
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Divided	14027.1	0	16411.9	1.17001
	ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570]	Divided	49	1	59	1.20408
141	cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	Subtracted	269.238	1	239.991	29.247
	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]	Divided	8991.19	0	7690.02	1.1692
	ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157]	Divided	49	1	59	1.20408
	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]	Subtracted	11119.7	0	9411.34	1708.36
142	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	Divided	49	1	59	1.20408
	thrombospondin 3 precursor. [swissprot;acc:p49746]	Subtracted	269.234	1	239.99	29.244
	transcription factor 4 (immunoglobulin transcription factor 2) (itf-2) (sl3-3 enhancer factor 2) (sef-2). [swissprot;acc:p15884]	Subtracted	18296	0	16614	1682
	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	Divided	7026.41	0	8214.41	1.16908
143	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]		49	1	59	1.20408
	dna directed rna polymerase ii polypeptide j-related gene isoform 3; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_032959]		13005.3	0	11124.8	1.16904
	prefoldin subunit 3 (von hippel-lindau binding protein 1) (vhl binding protein-1) (vbp-1) (hibbj46). [swissprot;acc:q15765]	Subtracted	7868	0	9545	1677
	splicing factor 4 isoform b; rna-binding protein. [refseq;acc:nm_021164]		211.382	1	240.133	28.751
144	cysteine-rich protein 1 (crp1) (crp). [swissprot;acc:p21291]		267.915	1	239.35	28.565
	dna directed rna polymerase ii polypeptide j-related gene isoform 1; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_145325]	Divided	13000.1	0	11123.4	1.16872
	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	Divided	319.651	1	265.686	1.20312
	zinc finger protein slug (neural crest transcription factor slug) (snail homolog 2). [swissprot;acc:o43623]	Subtracted	13893.1	0	12225.7	1667.4
145	lamin b2. [swissprot;acc:q03252]		13802	0	12135.4	1666.6
	likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745]		267.881	1	239.336	28.545
	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	Divided	319.546	1	265.639	1.20293
	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]		6817.49	0	7955.61	1.16694
146	coatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102). [swissprot;acc:p35606]		14662.1	0	12577.8	1.16571
	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]		319.531	1	265.632	1.20291
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Subtracted	4871.6	0	3208.8	1662.8
	smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [swissprot;acc:q16527]	Subtracted	267.879	1	239.336	28.543
147	60s ribosomal protein l7. [swissprot;acc:p18124]	Divided	9505.89	0	11080.3	1.16562
	lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [swissprot;acc:p50461]	Subtracted	267.842	1	239.32	28.522
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Divided	42.3003	1	50.7983	1.2009
	tubby protein homolog. [swissprot;acc:p50607]	Subtracted	10641.7	0	12303.7	1662
148	dj681n20.2 (novel protein similar to ferritin, light polypeptide (ftl)). [sptrembl;acc:q9byw6]		6058	0	7706.5	1648.5
	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]		198.444	1	226.582	28.138
	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	Divided	247.559	1	296.677	1.19841
	spectrin beta chain, brain 4 (spectrin, non-erythroid beta chain 4) (beta-v spectrin) (bspecv). [swissprot;acc:q9nrc6]		7863.63	0	6755.71	1.164
149	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]		170	1	142	1.19718
	block 23. [sptrembl;acc:q8nhw5]		13334.8	0	11469.3	1.16265
	mitochondrial 28s ribosomal protein s22 (s22mt) (mrp-s22) (gk002). [swissprot;acc:p82650]	Subtracted	15586.4	0	13942.8	1643.6
	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]		198.444	1	226.582	28.138
150	dimethylaniline monooxygenase [n-oxide forming] 3 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 3) (fmo 3) (dimethylaniline oxidase 3) (fmo form 2) (fmo ii). [swissprot;acc:p31513]		9130.38	0	7495.26	1635.12
	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	Divided	46	1	55	1.19565
	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	Subtracted	198.444	1	226.582	28.138
	zinc finger protein-like 1; zinc-finger protein in men1 region. [refseq;acc:nm_006782]	Divided	7516	0	8730	1.16152

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/