MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Rank	description	Value Type	Interaction Map	Network Comparison Type	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 29840 in total

Interaction Map  : High confidence

Rank	description	Value Type	Network Comparison Type	Filtered	green	red	network_comparison
4	cytohesin 4. [swissprot;acc:q9uia0]	Measured	Subtracted	1	33356.5	41482.5	8126
	hbs1-like. [refseq;acc:nm_006620]		Divided		698.5	2597.5	3.71868
		Squared			115.48	1596.92	13.8285
		Rooted			26.4292	50.9657	1.92839
			Subtracted				24.5365
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	Measured	Divided	0	89	0.00001	8900000
	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	Ranked			21883	8906	2.45711
	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	Rooted	Subtracted		7.61577	29.3087	21.6929
	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]	Ranked			21888	11525	10363
	pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]	Squared	Divided		2.81207	0.00001	281207
		Rooted			10.4403		1044030
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Ranked	Subtracted	1	232	337	105
	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]	Squared		0	105900	75446.7	30453.3
	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	Measured			21730	18704	3026
5	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Rooted		1	168.796	145.551	23.245
	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Measured			33356.5	41482.5	8126
	cytohesin 4. [swissprot;acc:q9uia0]	Ranked	Divided		28	15	1.86667
		Squared	Subtracted		263351	407289	143938
	histone h4. [swissprot;acc:p02304]	Measured		0	24446.3	21773.1	2673.2
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	Squared	Divided		1.87479	0.00001	187479
		Rooted			9.43398		943398
	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Measured			89		8900000
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]			1	339.5	1153.5	3.39764
		Squared			27.2805	314.926	11.544
		Rooted			18.4255	33.9632	1.84327
	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]		Subtracted	0	0	19.0788	19.0788
	transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]	Ranked			21888	11525	10363
	ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]		Divided		11965.7	5510.5	2.17144
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]		Subtracted	1	309	212	97
	zinc finger protein 277. [swissprot;acc:q9nrm2]	Squared		0	105900	75446.7	30453.3
6	ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973]				102814	73080.8	29733.2
	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Ranked	Divided	1	28	15	1.86667
		Squared	Subtracted		263351	407289	143938
	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	Measured	Divided	0	89	0.00001	8900000
	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Squared			1.87479		187479
		Rooted			9.43398		943398
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Measured		1	339.5	1153.5	3.39764
		Squared			27.2805	314.926	11.544
		Rooted			18.4255	33.9632	1.84327
	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	Ranked	Subtracted	0	14977	5865	9112
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	Rooted		1	168.796	145.551	23.245
	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]			0	27.8029	12.1655	15.6374
	protein x 0004. [refseq;acc:nm_016301]	Ranked		1	309	212	97
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Measured			36927.5	44490.5	7563
	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]			0	15605.1	13174.7	2430.4
	ubiquitin protein ligase. [refseq;acc:nm_130466]	Ranked	Divided		15339.2	7523	2.03897
7	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Measured	Subtracted	1	28492	21185	7307
	cab2. [refseq;acc:nm_033419]	Ranked	Divided	0	10950	21866	1.99689
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]			1	322	215	1.49767
	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	Squared		0	1.87479	0.00001	187479

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.