Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Gene Rank Value Type Network Comparison Type description Interaction Map green network_comparison Filtered red

Results: HTML CSV LaTeX

Showing element 551 to 600 of 29840 in total

Interaction Map

: High confidence

Rank	Value Type	Network Comparison Type	description	green	network_comparison	Filtered	red
35	Ranked	Subtracted	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	335.359	67.723	1	267.636
	Ranked	Subtracted	importin 9. [refseq;acc:nm_018085]	8691.76	4600.44	0	13292.2
	Squared	Divided	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	192141	1.80879	1	106226
		Divided	adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]	647.816	12.7767	0	50.7031
		Subtracted	bystin. [swissprot;acc:q13895]	32857.7	6288	0	26569.7
		Subtracted	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	192141	85915	1	106226
	Rooted	Divided	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	11.7898	2.02503	0	23.8747
		Divided	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	24.3679	1.65304	1	40.2812
		Subtracted	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	122.878	17.63	1	140.508
		Subtracted	serpin b12. [swissprot;acc:q96p63]	1.18697	9.10583	0	10.2928
36	Measured	Divided	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	907.741	2.02344	1	1836.76
		Divided	heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174]	56	2.80357	0	157
		Subtracted	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	18263	5430.7	1	23693.7
		Subtracted	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	925.298	660.772	0	1586.07
	Ranked	Divided	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	204.309	1.27519	1	260.532
		Divided	guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]	14964	1.4984	0	22422
		Subtracted	nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733]	8691.76	4600.44	0	13292.2
		Subtracted	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	254.434	66.493	1	320.927
	Squared	Divided	cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]	8.01325	10.5625	0	84.64
		Divided	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	192141	1.80879	1	106226
		Subtracted	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	146079	81081	1	227160
		Subtracted	huntingtin interacting protein e; huntingtin interactor protein e. [refseq;acc:nm_007076]	369010	5957	0	363053
	Rooted	Divided	4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404]	2.18581	1.96964	0	4.30525
		Divided	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	24.369	1.65294	1	40.2805
		Subtracted	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	1.2188	9.0897	0	10.3085
		Subtracted	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	43.1914	17.1626	1	26.0288
37	Measured	Divided	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	934.348	2.79409	0	334.401
		Divided	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	907.763	2.02339	1	1836.76
		Subtracted	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	18263	5430.7	1	23693.7
		Subtracted	wiskott-aldrich syndrome protein family member 3 (wasp-family protein member 3) (verprolin homology domain-containing protein 3). [swissprot;acc:q9upy6]	4550.64	652.25	0	5202.89
	Ranked	Divided	dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]	2582	1.49458	0	3859
		Divided	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	253	1.27273	1	322
		Subtracted	dystrobrevin binding protein 1; dysbindin. [refseq;acc:nm_032122]	7533.33	4594.97	0	12128.3
		Subtracted	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	333.165	66.449	1	266.716
	Squared	Divided	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	1034.13	10.2338	0	101.05
		Divided	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	192141	1.80879	1	106226
		Subtracted	dyskerin (nucleolar protein nap57) (cbf5 homolog). [swissprot;acc:o60832]	38271.3	5857.6	0	32413.7
		Subtracted	trs85 homolog. [swissprot;acc:q9y2l5]	146079	81081	1	227160
	Rooted	Divided	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	24.3691	1.65293	1	40.2805
		Divided	small nuclear ribonucleoprotein associated proteins b and b' (snrnp-b) (sm protein b/b') (sm-b/sm-b') (smb/smb'). [swissprot;acc:p14678]	9.39626	1.94348	0	4.83477
		Subtracted	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	43.1914	17.1626	1	26.0288
		Subtracted	nadh-ubiquinone oxidoreductase 13 kda-b subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-13kd-b) (ci-13kd-b) (complex i subunit b13). [swissprot;acc:q16718]	25.3969	9.0874	0	16.3095
38	Measured	Divided	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	907.774	2.02337	1	1836.76
		Divided	zinc finger protein slug (neural crest transcription factor slug) (snail homolog 2). [swissprot;acc:o43623]	120.429	2.65727	0	320.012
		Subtracted	clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]	6127.24	630.23	0	5497.01
		Subtracted	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	18263	5430.7	1	23693.7
	Ranked	Divided	cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]	10771	1.48976	0	7230
		Divided	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	253	1.27273	1	322
		Subtracted	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	333.281	66.348	1	266.933
		Subtracted	p28 ing5. [refseq;acc:nm_032329]	7562.05	4562.75	0	12124.8

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/