Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Value Type Gene Rank Network Comparison Type green Interaction Map description network_comparison red Filtered
Results: HTML CSV LaTeX Showing element 451 to 500 of 6456 in total
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1
Rank
Network Comparison Type
green
description
network_comparison
red
226 Divided 269.238 cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747] 1.12187 239.991
Subtracted 266.673 protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378] 24.52 242.153
227 Divided 269.234 thrombospondin 3 precursor. [swissprot;acc:p49746] 1.12186 239.99
Subtracted 268.604 methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582] 24.478 244.126
228 Divided 202.088 sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489] 1.12036 226.411
Subtracted 268.604 methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579] 24.478 244.126
229 Divided 202.094 breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567] 1.12028 226.401
Subtracted 266.663 60s ribosomal protein l3-like. [swissprot;acc:q92901] 24.468 242.195
230 Divided 267.915 cysteine-rich protein 1 (crp1) (crp). [swissprot;acc:p21291] 1.11934 239.35
Subtracted 267.017 protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567] 24.323 242.694
231 Divided 267.881 likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745] 1.11927 239.336
Subtracted 202.088 sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489] 24.323 226.411
232 Divided 267.879 smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [swissprot;acc:q16527] 1.11926 239.336
Subtracted 202.094 breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567] 24.307 226.401
233 Divided 267.842 lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [swissprot;acc:p50461] 1.11918 239.32
Subtracted 259.984 60s ribosomal protein l7. [swissprot;acc:p18124] 24.257 235.727
234 Divided 256.835 chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0] 1.11905 287.41
Subtracted 268.195 40s ribosomal protein s23. [swissprot;acc:p39028] 24.251 243.944
235 Divided 254.15 phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [swissprot;acc:p00439] 1.11785 227.357
Subtracted 268.195 28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235] 24.251 243.944
236 Divided 254.15 pp3111 protein. [refseq;acc:nm_022156] 1.11785 227.357
Subtracted 228.42 histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576] 24.224 252.644
237 Divided 254.15 syntaxin 18. [swissprot;acc:q9p2w9] 1.11785 227.357
Subtracted 266.18 mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001] 24.169 242.011
238 Divided 254.15 rd protein. [swissprot;acc:p18615] 1.11785 227.357
Subtracted 228.356 metastasis-associated protein mta1. [swissprot;acc:q13330] 24.156 252.512
239 Divided 254.15 glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417] 1.11785 227.357
Subtracted 267.962 dna-directed rna polymerase ii largest subunit (ec 2.7.7.6) (rpb1). [swissprot;acc:p24928] 24.145 243.817
240 Divided 254.15 androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108] 1.11785 227.357
Subtracted 228.297 chromatin assembly factor 1 subunit c (caf-1 subunit c) (chromatin assembly factor i p48 subunit) (caf-i 48 kda subunit) (caf-ip48) (retinoblastoma binding protein p48) (retinoblastoma-binding protein 4) (rbbp-4) (msi1 protein homolog). [swissprot;acc:q09028] 24.093 252.39
241 Divided 254.15 atp synthase b chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p24539] 1.11785 227.357
Subtracted 265.96 epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830] 24.068 241.892
242 Divided 254.15 j domain containing protein 1. [swissprot;acc:q9ukb3] 1.11785 227.357
Subtracted 265.959 c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02] 24.067 241.892
243 Divided 254.15 sorting nexin 13 (rgs domain- and phox domain-containing protein) (rgs-px1). [swissprot;acc:q9y5w8] 1.11785 227.357
Subtracted 265.945 60s ribosomal protein l23a. [swissprot;acc:p29316] 24.061 241.884
244 Divided 254.15 ba127l20.1 (novel glutathione-s-transferase). [sptrembl;acc:q9h4y5] 1.11785 227.357
Subtracted 265.924 60s ribosomal protein l5. [swissprot;acc:p46777] 24.025 241.899
245 Divided 202.333 small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331] 1.11751 226.109
Subtracted 264.729 60s ribosomal protein l19. [swissprot;acc:p14118] 23.999 240.73
246 Divided 212.363 eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760] 1.11748 237.312
Subtracted 267.528 60s ribosomal protein l12 like protein. [sptrembl;acc:o60886] 23.945 243.583
247 Divided 212.41 rna-binding protein. [refseq;acc:nm_019027] 1.11719 237.302
Subtracted 267.527 60s ribosomal protein l12. [swissprot;acc:p30050] 23.944 243.583
248 Divided 212.41 apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576] 1.11719 237.302
Subtracted 267.527 dj999l4.1 (novel protein similar to ribosomal protein l12 (rpl12)). [sptrembl;acc:q9nq02] 23.944 243.583
249 Divided 212.41 ns1-associated protein 1. [refseq;acc:nm_006372] 1.11719 237.302
Subtracted 202.333 small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331] 23.776 226.109
250 Divided 212.41 heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390] 1.11719 237.302
Subtracted 186.95 pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388] 23.743 210.693

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/